Mbd3tm1Bh
Targeted Allele Detail
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|
| Symbol: |
Mbd3tm1Bh |
| Name: |
methyl-CpG binding domain protein 3; targeted mutation 1, Brian Hendrich |
| MGI ID: |
MGI:2388006 |
| Synonyms: |
Mbd3(-) |
| Gene: |
Mbd3 Location: Chr10:80228373-80235365 bp, - strand Genetic Position: Chr10, 39.72 cM
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| Alliance: |
Mbd3tm1Bh page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:68356
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| Parent Cell Line: |
E14TG2a (ES Cell)
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| Strain of Origin: |
129P2/OlaHsd
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| Allele Type: |
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Targeted (Null/knockout, Reporter) |
| Mutations: |
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Insertion, Intragenic deletion
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Mutation details: Exons 2-7 were replaced by an internal ribosomal entry site (IRES) followed by a betageo (beta-galactosidase/neomycin resistance) cassette via homologous recombination so that beta-galactosidase is expressed from the endogenous promoter. Homozygous mutant embryos were observed up to day E8.5.
(J:68356, J:167984)
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| Key: |
| hm |
homozygous |
ht |
heterozygous |
tg |
involves transgenes |
√ |
phenotype observed |
| cn |
conditional genotype |
cx |
complex: > 1 genome feature |
ot |
other: hemizygous, indeterminate,... |
N |
normal phenotype |
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Genotype/
Background: |
| Allelic Composition | Genetic Background | Cell Line(s) |
|---|
Loading... | | | involves: 129P2/OlaHsd * C57BL/6 | | | | involves: 129P2/OlaHsd * C57BL/6 | |
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| Phenotypes: |
| Affected Systems |
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mortality/aging
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√
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√
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embryonic lethality between implantation and somite formation, complete penetrance
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√
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prenatal lethality, incomplete penetrance
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√
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Mbd3 Mutation: |
58 strains or lines available
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|
| Original: |
J:68356 Hendrich B, et al., Closely related proteins MBD2 and MBD3 play distinctive but interacting roles in mouse development. Genes Dev. 2001 Mar 15;15(6):710-23 |
| All: |
4 reference(s) |
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Analysis Tools
