PubMed ID MGI Ref. ID | Title | Curated Data | Vol(Iss)Pg | ||||
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Tarchini B; Tadenev AL; Devanney N; Cayouette M | A link between planar polarity and staircase-like bundle architecture in hair cells. | Development | 2016 | 143 (21) 3926-3932 | 5.595118 | ||
Sensory perception in the inner ear relies on the hair bundle, the highly polarized brush of movement detectors that crowns hair cells. We previously showed that, in the mouse cochlea, the edge of the forming bundle is defined by the 'bare zone', a microvilli-free sub-region of apical membrane specified by the Insc-LGN-Galphai protein complex. We now report that LGN and Galphai also occupy the very tip of stereocilia that directly abut the bare zone. We demonstrate that LGN and Galphai are both essential for promoting the elongation and differential identity of stereocilia across rows. Interestingly, we also reveal that total LGN-Galphai protein amounts are actively balanced between the bare zone and stereocilia tips, suggesting that early planar asymmetry of protein enrichment at the bare zone confers adjacent stereocilia their tallest identity. We propose that LGN and Galphai participate in a long-inferred signal that originates outside the bundle to model its staircase-like architecture, a property that is essential for direction sensitivity to mechanical deflection and hearing. |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/17/2024 MGI 6.24 |
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