Mcl1 MGI Mouse Gene Detail - MGI:101769 - myeloid cell leukemia sequence 1

Symbol

Mcl1
Name

myeloid cell leukemia sequence 1
Synonyms

Mcl-1

Feature Type

protein coding gene
IDs

MGI:101769
NCBI Gene: 17210
Alliance

gene page
Transcription Start Sites

15 TSS

Sequence Map

Chr3:95566099-95570487 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 40.74 cM
Mapping Data

3 experiments

SNPs within 2kb

119 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_101769	protein coding gene	Chr3:95564017-95583553 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027590	protein coding gene	Chr3:96423928-96428316 (+)
A/J	MGP_AJ_G0027549	protein coding gene	Chr3:93411713-93416101 (+)
AKR/J	MGP_AKRJ_G0027516	protein coding gene	Chr3:95587858-95592246 (+)
BALB/cJ	MGP_BALBcJ_G0027561	protein coding gene	Chr3:93188342-93192730 (+)
C3H/HeJ	MGP_C3HHeJ_G0027294	protein coding gene	Chr3:95880494-95884882 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0028009	protein coding gene	Chr3:99975787-99980175 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025349	protein coding gene	Chr3:89739847-89744235 (+)
CAST/EiJ	MGP_CASTEiJ_G0026744	protein coding gene	Chr3:95144685-95149072 (+)
CBA/J	MGP_CBAJ_G0027271	protein coding gene	Chr3:103621183-103625571 (+)
DBA/2J	MGP_DBA2J_G0027410	protein coding gene	Chr3:92699370-92703758 (+)
FVB/NJ	MGP_FVBNJ_G0027381	protein coding gene	Chr3:90772332-90776720 (+)
LP/J	MGP_LPJ_G0027519	protein coding gene	Chr3:97734692-97739080 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027408	protein coding gene	Chr3:109736122-109740511 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028063	protein coding gene	Chr3:95232199-95236587 (+)
PWK/PhJ	MGP_PWKPhJ_G0026472	protein coding gene	Chr3:92587442-92591827 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026293	protein coding gene	Chr3:93512716-93517105 (+)
WSB/EiJ	MGP_WSBEiJ_G0026826	protein coding gene	Chr3:95616693-95621081 (+)

Human Ortholog

MCL1, MCL1 apoptosis regulator, BCL2 family member

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MCL1, MCL1 apoptosis regulator, BCL2 family member
Synonyms

bcl2-L-3, BCL2L3, EAT, Mcl-1, mcl1/EAT, MCL1-ES, MCL1L, MCL1S, TM
Links

HGNC:6943

NCBI Gene ID: 4170

neXtProt AC: NX_Q07820

UniProt: Q07820
Chr Location

1q21.2; chr1:150560895-150579738 (-) GRCh38

MGI Vertebrate Homology

Mcl1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: MCL1
Gene Tree

Mcl1

Diseases

4 with human MCL1 associations

				Human Disease	Mouse Models
				colorectal cancer IDs colorectal cancer DOID:9256 ICD10CM:C18.9 KEGG:05210 MESH:D015179 NCI:C2956 NCI:C4978 OMIM:114500 UMLS_CUI:C0009404 UMLS_CUI:C0346629
				lung adenocarcinoma IDs lung adenocarcinoma DOID:3910 DOID:4826 EFO:0000571 MESH:D000077192 NCI:C27745 NCI:C3512 UMLS_CUI:C0152013 UMLS_CUI:C1335060
				lung cancer IDs lung cancer DOID:1324 DOID:13075 DOID:1322 DOID:9881 ICD10CM:C34.1 ICD10CM:C34.2 ICD10CM:C34.3 ICD9CM:162.3 ICD9CM:162.4 ICD9CM:162.5 ICD9CM:162.8 OMIM:211980 OMIM:608935 OMIM:612571 OMIM:612593 OMIM:614210 UMLS_CUI:C0024624 UMLS_CUI:C0153491 UMLS_CUI:C0153492 UMLS_CUI:C0153493
				lung non-small cell carcinoma IDs lung non-small cell carcinoma DOID:3908 EFO:0003060 KEGG:05223 MESH:D002289 NCI:C2926 UMLS_CUI:C0007131

Click on a disease name to see all genes associated with that disease.

References

1 with disease annotations

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Phenotype Summary

60 phenotypes from 7 alleles in 14 genetic backgrounds
6 phenotypes from multigenic genotypes
113 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

71
Chemically induced (other)

1
Endonuclease-mediated

5
Gene trapped

57
Radiation induced

1
Targeted

7
Genomic Mutations

2 involving Mcl1
Find Mice (IMSR)

35 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for a targeted null mutation form blastocysts which die around the time of implantation and fail to hatch in vitro. Conditional mutants shows increased apoptosis of B and T lymphocytes and arrested lymphocyte development.

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All GO Annotations

57
GO References

25

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

793
Tissues

65
cDNA Data

245
Literature Summary

20

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase mcl1

ZFIN mcl1a, mcl1b

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All Sequences

57
RefSeq

6
UniProt

1
CCDS

CCDS57236.1

Ensembl

ENSMUSG00000038612 (Evidence)
NCBI Gene

17210

			Length	Strain/Species	Flank
genomic	ENSMUSG00000038612	Ensembl Gene Model \| MGI Sequence Detail	4389	C57BL/6J	± kb
transcript	ENSMUST00000037947	Ensembl \| MGI Sequence Detail	3418	Not Applicable
polypeptide	ENSMUSP00000044048	Ensembl \| MGI Sequence Detail	331	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000010240 induced myeloid leukemia cell differentiation protein Mcl-1

(term hierarchy)
PDB

1WSX, 2JM6, 2NL9, 2NLA, 2ROC, 2ROD, 3D7V, 3IO9, 4BPI, 4BPJ, 4G35, 5KU9, 5MES, 5MEV, 5VX2, 6DM8
InterPro Domains

IPR020717 Apoptosis regulator, Bcl-2, BH1 motif, conserved site

IPR020726 Apoptosis regulator, Bcl-2, BH2 motif, conserved site

IPR020728 Apoptosis regulator, Bcl-2, BH3 motif, conserved site

IPR013281 Apoptosis regulator, Mcl-1

IPR046371 Bcl-2, Bcl-2 homology region 1-3

IPR026298 Bcl-2 family

IPR002475 Bcl2-like

IPR036834 Bcl-2-like superfamily

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All nucleic 249

cDNA 245

Primer pair 4

Microarray probesets 10

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MGD-MRK-18576, MGI:2140009

Summaries

All 229

Developmental Gene Expression 20

Diseases 1

Gene Ontology 25

Phenotypes 113
Earliest

J:20820 Craig RW, et al., Human and mouse chromosomal mapping of the myeloid cell leukemia-1 gene: MCL1 maps to human chromosome 1q21, a region that is frequently altered in preneoplastic and neoplastic disease. Genomics. 1994 Sep 15;23(2):457-63
Latest

J:347662 Wright T, et al., Anti-apoptotic MCL-1 promotes long-chain fatty acid oxidation through interaction with ACSL1. Mol Cell. 2024 Apr 4;84(7):1338-1353.e8

TSS for Mcl1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr30625	Chr3:95566025-95566034 (+)	-69 bp
Tssr30626	Chr3:95566049-95566060 (+)	-44 bp
Tssr30627	Chr3:95566082-95566098 (+)	-9 bp
Tssr30628	Chr3:95566361-95566393 (+)	278 bp
Tssr30629	Chr3:95566409-95566440 (+)	326 bp
Tssr30630	Chr3:95566571-95566591 (+)	482 bp
Tssr30631	Chr3:95566613-95566631 (+)	523 bp
Tssr30632	Chr3:95566933-95567024 (+)	880 bp
Tssr30633	Chr3:95568310-95568363 (+)	2,238 bp
Tssr30634	Chr3:95568988-95569062 (+)	2,926 bp
Tssr30635	Chr3:95569070-95569127 (+)	3,000 bp
Tssr30636	Chr3:95569170-95569216 (+)	3,094 bp
Tssr30637	Chr3:95569343-95569366 (+)	3,256 bp
Tssr30638	Chr3:95569388-95569461 (+)	3,326 bp
Tssr30639	Chr3:95569493-95569508 (+)	3,402 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24