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Fabp5 Gene Detail
Summary
  • Symbol
    Fabp5
  • Name
    fatty acid binding protein 5, epidermal
  • Synonyms
    Fabpe E-FABP, Klbp, mal1, Unknown Klbp, keratinocyte lipid binding protein
  • Feature Type
    protein coding gene
  • IDs
    MGI:101790
    NCBI Gene: 16592
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:10077645-10081670 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 2.47 cM, cytoband A1-A3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    251 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_101790
 protein coding gene Chr3:10077608-10081670 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027059
 protein coding gene Chr3:6953444-6957511 (+)
A/J MGP_AJ_G0027023
 protein coding gene Chr3:7116319-7128020 (+)
AKR/J MGP_AKRJ_G0026993
 protein coding gene Chr3:7020189-7024233 (+)
BALB/cJ MGP_BALBcJ_G0027032
 protein coding gene Chr3:6833330-6838170 (+)
C3H/HeJ MGP_C3HHeJ_G0026772
 protein coding gene Chr3:7334170-7338256 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027476
 protein coding gene Chr3:7598487-7606353 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024838
 protein coding gene Chr3:6027208-6031214 (+)
CAST/EiJ MGP_CASTEiJ_G0026230
 protein coding gene Chr3:7347385-7354443 (+)
CBA/J MGP_CBAJ_G0026750
 protein coding gene Chr3:7581981-7591743 (+)
DBA/2J MGP_DBA2J_G0026886
 protein coding gene Chr3:6700404-6704473 (+)
FVB/NJ MGP_FVBNJ_G0026853
 protein coding gene Chr3:6629047-6633963 (+)
LP/J MGP_LPJ_G0026996
 protein coding gene Chr3:7478627-7483365 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026873
 protein coding gene Chr3:8626227-8631352 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027536
 protein coding gene Chr3:6891247-6895351 (+)
PWK/PhJ MGP_PWKPhJ_G0025965
 protein coding gene Chr3:6927877-6932004 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025768
 protein coding gene Chr3:7018267-7022341 (+)
WSB/EiJ MGP_WSBEiJ_G0026301
 protein coding gene Chr3:6857427-6861471 (+)



Homology
more
  • Human Ortholog
    FABP5, fatty acid binding protein 5
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FABP5, fatty acid binding protein 5
  • Synonyms
    E-FABP, EFABP, KFABP, PA-FABP, PAFABP
  • Links
    NCBI Gene ID: 2171
    neXtProt AC: NX_Q01469
    UniProt: Q01469

  • Chr Location
    8q21.13; chr8:81280536-81284777 (+)  GRCh38
  • Human Ortholog
    FABP5P3, fatty acid binding protein 5 pseudogene 3
  • Synonyms
    FABP5L3
  • Links
    NCBI Gene ID: 220832
    UniProt: A8MUU1

  • Chr Location
    7q36.1; chr7:152435695-152443176 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 3 alleles in 2 genetic backgrounds
    32 phenotypes from multigenic genotypes
    54 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene, depending on allele, display impaired skin barrier function or resistance to diet-induced obesity, showing decreased adipose tissue and imporved glucose tolerance and insulin sensitivity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    41
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    926
  • Tissues
    91
  • cDNA Data
    164
  • Literature Summary
    27
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16592 NCBI Gene Model | MGI Sequence Detail 4026 C57BL/6J ±  kb
    transcript NM_010634 RefSeq | MGI Sequence Detail 969 C57BL/6  
    polypeptide Q05816 UniProt | EBI | MGI Sequence Detail 135 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 176
      Genomic 7
      cDNA 165
      Primer pair 4

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-18598
    References
    more
    • Summaries
      All 120
      Developmental Gene Expression 27
      Gene Ontology 10
      Phenotypes 54
    • Earliest
      J:14048 Krieg P, et al., Tumor-specific overexpression of a novel keratinocyte lipid-binding protein. Identification and characterization of a cloned sequence activated during multistage carcinogenesis in mouse skin. J Biol Chem. 1993 Aug 15;268(23):17362-9
    • Latest
      J:348585 Hao J, et al., Keratinocyte FABP5-VCP complex mediates recruitment of neutrophils in psoriasis. Cell Rep. 2023 Nov 14;42(11):113449
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    11/12/2024
    MGI 6.24     		The Jackson Laboratory