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Pla2g1b Gene Detail
Summary
  • Symbol
    Pla2g1b
  • Name
    phospholipase A2, group IB, pancreas
  • Synonyms
    Pla2a, sPLA2IB
  • Feature Type
    protein coding gene
  • IDs
    MGI:101842
    NCBI Gene: 18778
  • Alliance
    gene page
  • Transcription Start Sites
    22 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:115604321-115612781 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 56.10 cM, cytoband F1-G1.1
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    383 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_101842
 protein coding gene Chr5:115604201-115612781 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029970
 protein coding gene Chr5:118351531-118362923 (+)
A/J MGP_AJ_G0029934
 protein coding gene Chr5:113635208-113644108 (+)
AKR/J MGP_AKRJ_G0029873
 protein coding gene Chr5:117280475-117289658 (+)
BALB/cJ MGP_BALBcJ_G0029945
 protein coding gene Chr5:115030948-115040537 (+)
C3H/HeJ MGP_C3HHeJ_G0029665
 protein coding gene Chr5:117791056-117800500 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030400
 protein coding gene Chr5:122905793-122915626 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027627
 protein coding gene Chr5:108410763-108419572 (+)
CAST/EiJ MGP_CASTEiJ_G0029074
 protein coding gene Chr5:116723746-116732723 (+)
CBA/J MGP_CBAJ_G0029633
 protein coding gene Chr5:127629191-127643475 (+)
DBA/2J MGP_DBA2J_G0029783
 protein coding gene Chr5:113710460-113736599 (+)
FVB/NJ MGP_FVBNJ_G0029739
 protein coding gene Chr5:112540859-112549204 (+)
LP/J MGP_LPJ_G0029871
 protein coding gene Chr5:118910318-118920893 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029770
 protein coding gene Chr5:131934189-131945861 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030441
 protein coding gene Chr5:116753403-116762567 (+)
PWK/PhJ MGP_PWKPhJ_G0028787
 protein coding gene Chr5:112369220-112379280 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028625
 protein coding gene Chr5:114302418-114310623 (+)
WSB/EiJ MGP_WSBEiJ_G0029149
 protein coding gene Chr5:117344476-117352670 (+)



Homology
more
  • Human Ortholog
    PLA2G1B, phospholipase A2 group IB
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PLA2G1B, phospholipase A2 group IB
  • Synonyms
    PLA2, PLA2A, PPLA2
  • Links
    NCBI Gene ID: 5319
    neXtProt AC: NX_P04054
    UniProt: P04054

  • Chr Location
    12q24.31; chr12:120322115-120327779 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 1 allele in 1 genetic background
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display abnormalities in lipid absorption, increased insulin sensitivity and improved glucose tolerance.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    52
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    808
  • Tissues
    102
  • cDNA Data
    49
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000029522 Ensembl Gene Model | MGI Sequence Detail 8461 C57BL/6J ±  kb
    transcript ENSMUST00000031495 Ensembl | MGI Sequence Detail 557 Not Applicable  
    polypeptide ENSMUSP00000031495 Ensembl | MGI Sequence Detail 146 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 52
      Genomic 1
      cDNA 49
      Primer pair 1
      Other 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-13343, MGD-MRK-18663
    References
    more
    • Summaries
      All 59
      Developmental Gene Expression 4
      Gene Ontology 10
      Phenotypes 17
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:353367 Taketomi Y, et al., Lipid-orchestrated paracrine circuit coordinates mast cell maturation and anaphylaxis through functional interaction with fibroblasts. Immunity. 2024 Aug 13;57(8):1828-1847.e11
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory