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Gnb5 Gene Detail
Summary
  • Symbol
    Gnb5
  • Name
    guanine nucleotide binding protein (G protein), beta 5
  • Synonyms
    G beta 5, Gbeta5
  • Feature Type
    protein coding gene
  • IDs
    MGI:101848
    NCBI Gene: 14697
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:75213570-75253158 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 42.30 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1505 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_101848
 protein coding gene Chr9:75213570-75253205 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035036
 protein coding gene Chr9:75607965-75642575 (+)
A/J MGP_AJ_G0035017
 protein coding gene Chr9:72962822-72997510 (+)
AKR/J MGP_AKRJ_G0034946
 protein coding gene Chr9:74715706-74753361 (+)
BALB/cJ MGP_BALBcJ_G0035009
 protein coding gene Chr9:72648848-72683098 (+)
C3H/HeJ MGP_C3HHeJ_G0034718
 protein coding gene Chr9:75182890-75217639 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035528
 protein coding gene Chr9:77628122-77663086 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032439
 protein coding gene Chr9:72334393-72369969 (+)
CAST/EiJ MGP_CASTEiJ_G0034040
 protein coding gene Chr9:75526517-75562298 (+)
CBA/J MGP_CBAJ_G0034691
 protein coding gene Chr9:80277736-80313872 (+)
DBA/2J MGP_DBA2J_G0034850
 protein coding gene Chr9:72645164-72679071 (+)
FVB/NJ MGP_FVBNJ_G0034792
 protein coding gene Chr9:71947506-71981748 (+)
LP/J MGP_LPJ_G0034931
 protein coding gene Chr9:75866128-75899411 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034833
 protein coding gene Chr9:81374759-81409994 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035550
 protein coding gene Chr9:74869701-74906653 (+)
PWK/PhJ MGP_PWKPhJ_G0033744
 protein coding gene Chr9:72926561-72962141 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033577
 protein coding gene Chr9:75104160-75139968 (+)
WSB/EiJ MGP_WSBEiJ_G0034152
 protein coding gene Chr9:74789781-74826513 (+)



Homology
more
  • Human Ortholog
    GNB5, G protein subunit beta 5
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GNB5, G protein subunit beta 5
  • Synonyms
    GB5, gbeta5, HG2E, IDDCA, LADCI, LDMLS1, LDMLS2
  • Links
    NCBI Gene ID: 10681
    neXtProt AC: NX_O14775
    UniProt: O14775

  • Chr Location
    15q21.2; chr15:52115100-52191392 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human GNB5 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 2 alleles in 3 genetic backgrounds
    11 phenotypes from multigenic genotypes
    37 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation are runty and exhibit high preweaning mortality. Survivors are apparently normal, but show prolonged photoresponses and defective adaptation in rod cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    39
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    749
  • Tissues
    33
  • cDNA Data
    15
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032192 Ensembl Gene Model | MGI Sequence Detail 39589 C57BL/6J ±  kb
    transcript ENSMUST00000213990 Ensembl | MGI Sequence Detail 1803 Not Applicable  
    polypeptide ENSMUSP00000149938 Ensembl | MGI Sequence Detail 395 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 21
      Genomic 2
      cDNA 15
      Primer pair 4

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-18671
    References
    more
    • Summaries
      All 80
      Developmental Gene Expression 7
      Gene Ontology 13
      Phenotypes 37
    • Earliest
      J:19966 Watson AJ, et al., A fifth member of the mammalian G-protein beta-subunit family. Expression in brain and activation of the beta 2 isotype of phospholipase C. J Biol Chem. 1994 Sep 2;269(35):22150-6
    • Latest
      J:347917 Zhang J, et al., The association of GNB5 with Alzheimer disease revealed by genomic analysis restricted to variants impacting gene function. Am J Hum Genet. 2024 Mar 7;111(3):473-486
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory