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Ccl8 Gene Detail
Summary
  • Symbol
    Ccl8
  • Name
    C-C motif chemokine ligand 8
  • Synonyms
    1810063B20Rik, HC14, MCP-2, Scya8
  • Feature Type
    protein coding gene
  • IDs
    MGI:101878
    NCBI Gene: 20307
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:82006011-82007625 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 49.91 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    143 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_101878
 protein coding gene Chr11:82006011-82007625 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018825
 protein coding gene Chr11:83363487-83365101 (+)
A/J MGP_AJ_G0018792
 protein coding gene Chr11:80158248-80159862 (+)
AKR/J MGP_AKRJ_G0018762
 protein coding gene Chr11:82556806-82558420 (+)
BALB/cJ MGP_BALBcJ_G0018765
 protein coding gene Chr11:80551472-80553086 (+)
C3H/HeJ MGP_C3HHeJ_G0018579
 protein coding gene Chr11:82605636-82607250 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019217
 protein coding gene Chr11:85865131-85866745 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016851
 protein coding gene Chr11:77131489-77133104 (+)
CAST/EiJ MGP_CASTEiJ_G0018134
 protein coding gene Chr11:83164502-83166121 (+)
CBA/J MGP_CBAJ_G0018550
 protein coding gene Chr11:89630485-89632099 (+)
DBA/2J MGP_DBA2J_G0018658
 protein coding gene Chr11:79720517-79722131 (+)
FVB/NJ MGP_FVBNJ_G0018647
 protein coding gene Chr11:79266599-79268213 (+)
LP/J MGP_LPJ_G0018728
 protein coding gene Chr11:83893097-83894711 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018674
 protein coding gene Chr11:89811040-89812654 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019257
 protein coding gene Chr11:82822608-82824222 (+)
PWK/PhJ MGP_PWKPhJ_G0017904
 protein coding gene Chr11:80547316-80548937 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017695
 protein coding gene Chr11:82440477-82442100 (+)
WSB/EiJ MGP_WSBEiJ_G0018186
 protein coding gene Chr11:82700509-82702123 (+)



Homology
more
  • Human Ortholog
    CCL8, C-C motif chemokine ligand 8
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CCL8, C-C motif chemokine ligand 8
  • Synonyms
    HC14, MCP-2, MCP2, SCYA10, SCYA8
  • Links
    NCBI Gene ID: 6355
    neXtProt AC: NX_P80075
    UniProt: P80075

  • Chr Location
    17q12; chr17:34319435-34321402 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotype references
Some alleles of Ccl12 also affect expression of this gene.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    740
  • Tissues
    20
  • cDNA Data
    14
  • Literature Summary
    5
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 20307 NCBI Gene Model | MGI Sequence Detail 1615 C57BL/6J ±  kb
transcript NM_021443 RefSeq | MGI Sequence Detail 517 ZRU/MplStud  
polypeptide Q9Z121 UniProt | EBI | MGI Sequence Detail 97 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    2 Sequences
  • InterPro Domains
    IPR000827 CC chemokine, conserved site
    IPR039809 Chemokine beta/gamma/delta
    IPR001811 Chemokine interleukin-8-like domain
    IPR036048 Chemokine interleukin-8-like superfamily
Molecular
Reagents
less
  • All nucleic 15
    Genomic 1
    cDNA 14

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-18704, MGI:1913124, MGI:1917105
References
more
  • Summaries
    All 66
    Developmental Gene Expression 5
    Gene Ontology 7
    Phenotypes 21
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory