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E2f1 Gene Detail
Summary
  • Symbol
    E2f1
  • Name
    E2F transcription factor 1
  • Synonyms
    E2F-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:101941
    NCBI Gene: 13555
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:154401327-154411812 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 76.79 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    241 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_101941
 protein coding gene Chr2:154401320-154411812 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026719
 protein coding gene Chr2:159314867-159329909 (-)
A/J MGP_AJ_G0026685
 protein coding gene Chr2:152959482-152970088 (-)
AKR/J MGP_AKRJ_G0026656
 protein coding gene Chr2:157415134-157427086 (-)
BALB/cJ MGP_BALBcJ_G0026694
 protein coding gene Chr2:153257001-153269042 (-)
C3H/HeJ MGP_C3HHeJ_G0026437
 protein coding gene Chr2:157770089-157782309 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027143
 protein coding gene Chr2:163965416-163975745 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024513
 protein coding gene Chr2:146489544-146499991 (-)
CAST/EiJ MGP_CASTEiJ_G0025898
 protein coding gene Chr2:158085417-158093513 (-)
CBA/J MGP_CBAJ_G0026414
 protein coding gene Chr2:169930113-169940499 (-)
DBA/2J MGP_DBA2J_G0026551
 protein coding gene Chr2:152178674-152189150 (-)
FVB/NJ MGP_FVBNJ_G0026518
 protein coding gene Chr2:150567050-150578527 (-)
LP/J MGP_LPJ_G0026656
 protein coding gene Chr2:159433214-159444379 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026539
 protein coding gene Chr2:173978036-173988376 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027199
 protein coding gene Chr2:157285526-157296003 (-)
PWK/PhJ MGP_PWKPhJ_G0025632
 protein coding gene Chr2:151668161-151677945 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025435
 protein coding gene Chr2:156246056-156256093 (-)
WSB/EiJ MGP_WSBEiJ_G0025968
 protein coding gene Chr2:158209008-158220313 (-)



Homology
more
  • Human Ortholog
    E2F1, E2F transcription factor 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    E2F1, E2F transcription factor 1
  • Synonyms
    E2F-1, RBAP1, RBBP3, RBP3
  • Links
    NCBI Gene ID: 1869
    neXtProt AC: NX_Q01094
    UniProt: Q01094

  • Chr Location
    20q11.22; chr20:33675477-33686385 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with E2f1 mouse models; 6 with human E2F1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    68 phenotypes from 3 alleles in 8 genetic backgrounds
    269 phenotypes from multigenic genotypes
    277 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutants show defective T lymphocyte development, impaired pancreatic growth and beta cell function, altered glucose homeostasis, testicular atrophy, salivary gland and adipose tissue defects, and increased tumor induction.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    85
  • GO References
    32
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1103
  • Tissues
    255
  • cDNA Data
    18
  • Literature Summary
    66
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000027490 Ensembl Gene Model | MGI Sequence Detail 10486 C57BL/6J ±  kb
    transcript ENSMUST00000103145 Ensembl | MGI Sequence Detail 2732 Not Applicable  
    polypeptide ENSMUSP00000099434 Ensembl | MGI Sequence Detail 430 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 42
      Genomic 6
      cDNA 19
      Primer pair 14
      Other 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-18775, MGI:5485025
    References
    more
    • Summaries
      All 507
      Developmental Gene Expression 66
      Diseases 3
      Gene Ontology 32
      Phenotypes 277
    • Earliest
      J:16207 Carlsten H, et al., Histocompatibility complex gene products and exposure to oestrogen: two independent disease accelerating factors in murine lupus. Scand J Immunol. 1993 Oct;38(4):341-7
    • Latest
      J:359054 Morales-Soto W, et al., Endocannabinoids regulate enteric neuron-glia networks and visceral hypersensitivity following inflammation through a glial-dependent mechanism. Glia. 2024 Nov;72(11):2095-2114
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory