Lilrb4a MGI Mouse Gene Detail - MGI:102701 - leukocyte immunoglobulin-like receptor, subfamily B, member 4A

Lilrb4a Gene Detail

Symbol

Lilrb4a
Name

leukocyte immunoglobulin-like receptor, subfamily B, member 4A
Synonyms

CD85K, Gp49b, HM18, ILT3, Lilrb4

Feature Type

protein coding gene
IDs

MGI:102701
NCBI Gene: 14728
Alliance

gene page
Transcription Start Sites

30 TSS

Sequence Map

Chr10:51367052-51372707 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 25.50 cM, cytoband B4
Mapping Data

7 experiments

SNPs within 2kb

416 from dbSNP Build 142
Strain Annotations

1
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_102701	protein coding gene	Chr10:51366999-51372709 (+)
129S1/SvImJ	no annotation
A/J	no annotation
AKR/J	no annotation
BALB/cJ	no annotation
C3H/HeJ	no annotation
C57BL/6NJ	no annotation
CAROLI/EiJ	no annotation
CAST/EiJ	no annotation
CBA/J	no annotation
DBA/2J	no annotation
FVB/NJ	no annotation
LP/J	no annotation
NOD/ShiLtJ	no annotation
NZO/HlLtJ	no annotation
PWK/PhJ	no annotation
SPRET/EiJ	no annotation
WSB/EiJ	no annotation

Human Ortholog

LILRB4, leukocyte immunoglobulin like receptor B4

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LILRB4, leukocyte immunoglobulin like receptor B4
Synonyms

B4, CD85K, ILT-3, ILT3, LIR-5, LIR5
Links

HGNC:6608

NCBI Gene ID: 11006

neXtProt AC: NX_Q8NHJ6

UniProt: Q8NHJ6
Chr Location

19q13.42; chr19:54643889-54670359 (+) GRCh38

MGI Vertebrate Homology

Lilrb4a stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: LILRB4
Gene Tree

Lilrb4a

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Phenotype Summary

18 phenotypes from 3 alleles in 4 genetic backgrounds
27 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Chemically induced (other)

1
Endonuclease-mediated

8
Radiation induced

1
Targeted

5
Genomic Mutations

2 involving Lilrb4a
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

30 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for a targeted null mutation exhibit increased sensitivity to IgE-dependent passive cutaneous anaphylaxis and a reduced threshold for antigen challenge in active cutaneous anaphylaxis.

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All GO Annotations

69
GO References

20

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

725
Tissues

19
cDNA Data

31
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

43
RefSeq

11
UniProt

1
CCDS

CCDS23832.1

Ensembl

ENSMUSG00000112148 (Evidence)
NCBI Gene

14728

			Length	Strain/Species	Flank
genomic	ENSMUSG00000112148	Ensembl Gene Model \| MGI Sequence Detail	5656	C57BL/6J	± kb
transcript	ENSMUST00000078778	Ensembl \| MGI Sequence Detail	1381	Not Applicable
polypeptide	ENSMUSP00000077833	Ensembl \| MGI Sequence Detail	335	Not Applicable

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UniProt

1 Sequence

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All nucleic 37

Genomic 4

cDNA 33

Microarray probesets 3

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MGD-MRK-19605

Summaries

All 66

Developmental Gene Expression 2

Gene Ontology 20

Phenotypes 27
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Lilrb4a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr93260	Chr10:51367207-51367224 (+)	164 bp
Tssr93261	Chr10:51367235-51367249 (+)	190 bp
Tssr93262	Chr10:51367522-51367536 (+)	477 bp
Tssr93263	Chr10:51367601-51367629 (+)	563 bp
Tssr93264	Chr10:51367692-51367752 (+)	670 bp
Tssr93265	Chr10:51367993-51368046 (+)	968 bp
Tssr93266	Chr10:51368047-51368060 (+)	1,002 bp
Tssr93267	Chr10:51368069-51368134 (+)	1,050 bp
Tssr93268	Chr10:51368147-51368162 (+)	1,103 bp
Tssr93269	Chr10:51368174-51368191 (+)	1,131 bp
Tssr93270	Chr10:51368822-51368837 (+)	1,778 bp
Tssr93271	Chr10:51368937-51368955 (+)	1,894 bp
Tssr93272	Chr10:51368989-51369010 (+)	1,948 bp
Tssr93273	Chr10:51369250-51369281 (+)	2,214 bp
Tssr93274	Chr10:51369740-51369814 (+)	2,725 bp
Tssr93275	Chr10:51369907-51369947 (+)	2,875 bp
Tssr93276	Chr10:51369979-51370001 (+)	2,938 bp
Tssr93277	Chr10:51370030-51370049 (+)	2,988 bp
Tssr93278	Chr10:51370074-51370085 (+)	3,028 bp
Tssr93279	Chr10:51370218-51370241 (+)	3,178 bp
Tssr93280	Chr10:51370677-51370688 (+)	3,631 bp
Tssr93281	Chr10:51370717-51370736 (+)	3,675 bp
Tssr93282	Chr10:51370741-51370754 (+)	3,696 bp
Tssr93283	Chr10:51370818-51370844 (+)	3,779 bp
Tssr93284	Chr10:51371152-51371212 (+)	4,130 bp
Tssr93285	Chr10:51371377-51371396 (+)	4,335 bp
Tssr93286	Chr10:51371491-51371499 (+)	4,443 bp
Tssr93287	Chr10:51371853-51371883 (+)	4,816 bp
Tssr93288	Chr10:51372113-51372134 (+)	5,072 bp
Tssr93289	Chr10:51372181-51372186 (+)	5,132 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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