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Efna2 Gene Detail
Summary
  • Symbol
    Efna2
  • Name
    ephrin A2
  • Synonyms
    Cek7-L, Elf-1, Ephrin-A2, ephrin A6, Epl6, LERK-6
  • Feature Type
    protein coding gene
  • IDs
    MGI:102707
    NCBI Gene: 13637
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:80015316-80025844 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 39.72 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    252 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_102707
 protein coding gene Chr10:80015316-80025844 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017488
 protein coding gene Chr10:80766611-80777205 (+)
A/J MGP_AJ_G0017466
 protein coding gene Chr10:77941917-77952445 (+)
AKR/J MGP_AKRJ_G0017427
 protein coding gene Chr10:80072315-80082843 (+)
BALB/cJ MGP_BALBcJ_G0017428
 protein coding gene Chr10:78165466-78176003 (+)
C3H/HeJ MGP_C3HHeJ_G0017251
 protein coding gene Chr10:80168486-80179001 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017882
 protein coding gene Chr10:83548099-83558619 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015570
 protein coding gene Chr10:74167665-74178149 (+)
CAST/EiJ MGP_CASTEiJ_G0016818
 protein coding gene Chr10:80373347-80383882 (+)
CBA/J MGP_CBAJ_G0017223
 protein coding gene Chr10:86790203-86800717 (+)
DBA/2J MGP_DBA2J_G0017329
 protein coding gene Chr10:77163310-77173849 (+)
FVB/NJ MGP_FVBNJ_G0017323
 protein coding gene Chr10:76346336-76357052 (+)
LP/J MGP_LPJ_G0017400
 protein coding gene Chr10:81245186-81255760 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017349
 protein coding gene Chr10:88739550-88751059 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017923
 protein coding gene Chr10:80051016-80062996 (+)
PWK/PhJ MGP_PWKPhJ_G0016599
 protein coding gene Chr10:77027017-77037614 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016388
 protein coding gene Chr10:79032974-79043494 (+)
WSB/EiJ MGP_WSBEiJ_G0016878
 protein coding gene Chr10:80087588-80098138 (+)



Homology
more
  • Human Ortholog
    EFNA2, ephrin A2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EFNA2, ephrin A2
  • Synonyms
    ELF-1, EPLG6, HEK7-L, LERK-6, LERK6
  • Links
    NCBI Gene ID: 1943
    neXtProt AC: NX_O43921
    UniProt: O43921

  • Chr Location
    19p13.3; chr19:1284227-1301431 (+)  GRCh38
Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 2 alleles in 3 genetic backgrounds
    13 phenotypes from multigenic genotypes
    50 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozgous null mice exhibit increased neural progenitor cell proliferation and abnormalities in sensory projections to the superior colliculus
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    956
  • Tissues
    196
  • cDNA Data
    33
  • Literature Summary
    60
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13637 NCBI Gene Model | MGI Sequence Detail 10529 C57BL/6J ±  kb
    transcript NM_007909 RefSeq | MGI Sequence Detail 2153 ZRU/MplStud  
    polypeptide P52801 UniProt | EBI | MGI Sequence Detail 209 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 41
      cDNA 33
      Primer pair 4
      Other 4

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-19611
    References
    more
    • Summaries
      All 140
      Developmental Gene Expression 60
      Diseases 1
      Gene Ontology 9
      Phenotypes 50
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory