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Polr2k Gene Detail
Summary
  • Symbol
    Polr2k
  • Name
    polymerase (RNA) II (DNA directed) polypeptide K
  • Synonyms
    ABC10-alpha, MafY, Mt1a, RPABC4, RPB10alpha, RPB12, RPB7.0
  • Feature Type
    protein coding gene
  • IDs
    MGI:102725
    NCBI Gene: 17749
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:36174156-36177156 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 14.46 cM, cytoband A2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    191 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_102725
 protein coding gene Chr15:36174156-36177158 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021791
 protein coding gene Chr15:34552302-34555265 (+)
A/J MGP_AJ_G0021752
 protein coding gene Chr15:33254737-33257733 (+)
AKR/J MGP_AKRJ_G0021730
 protein coding gene Chr15:34175966-34179842 (+)
BALB/cJ MGP_BALBcJ_G0021758
 protein coding gene Chr15:33262622-33265622 (+)
C3H/HeJ MGP_C3HHeJ_G0021533
 protein coding gene Chr15:34145244-34148218 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022197
 protein coding gene Chr15:35858116-35862428 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019735
 protein coding gene Chr15:31065323-31068447 (+)
CAST/EiJ MGP_CASTEiJ_G0021049
 protein coding gene Chr15:34546947-34549903 (+)
CBA/J MGP_CBAJ_G0021502
 protein coding gene Chr15:37021010-37024003 (+)
DBA/2J MGP_DBA2J_G0021626
 protein coding gene Chr15:33077390-33080377 (+)
FVB/NJ MGP_FVBNJ_G0021604
 protein coding gene Chr15:32477289-32480278 (+)
LP/J MGP_LPJ_G0021695
 protein coding gene Chr15:34454403-34457286 (+)
NOD/ShiLtJ no annotation
NZO/HlLtJ MGP_NZOHlLtJ_G0022220
 protein coding gene Chr15:34330486-34333485 (+)
PWK/PhJ MGP_PWKPhJ_G0020793
 protein coding gene Chr15:33095517-33098614 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020631
 protein coding gene Chr15:34026331-34029343 (+)
WSB/EiJ MGP_WSBEiJ_G0021105
 protein coding gene Chr15:34296452-34299440 (+)



Homology
more
  • Human Ortholog
    POLR2K, RNA polymerase II, I and III subunit K
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    POLR2K, RNA polymerase II, I and III subunit K
  • Synonyms
    ABC10-alpha, hRPB7.0, hsRPB10a, RPABC4, RPB10alpha, RPB12, RPB7.0
  • Links
    NCBI Gene ID: 5440
    neXtProt AC: NX_P53803
    UniProt: P53803

  • Chr Location
    8q22.2; chr8:100150623-100154003 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    813
  • Tissues
    22
  • cDNA Data
    36
  • Literature Summary
    4
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000045996 Ensembl Gene Model | MGI Sequence Detail 3001 C57BL/6J ±  kb
transcript ENSMUST00000057177 Ensembl | MGI Sequence Detail 601 Not Applicable  
polypeptide ENSMUSP00000051968 Ensembl | MGI Sequence Detail 99 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000012998 DNA-directed RNA polymerases I, II, and III subunit RPABC4
    (term hierarchy)
  • InterPro Domains
    IPR039747 DNA-directed RNA polymerases I, II, and III subunit RPABC4
    IPR006591 RNA polymerase archaeal subunit P/eukaryotic subunit RPABC4
    IPR029040 RNA polymerase subunit RPABC4/transcription elongation factor Spt4
Molecular
Reagents
less
  • All nucleic 38
    cDNA 36
    Primer pair 2

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-19629
References
more
  • Summaries
    All 38
    Developmental Gene Expression 4
    Gene Ontology 6
    Phenotypes 8
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:226028 Lewandowski JP, et al., Spatiotemporal regulation of GLI target genes in the mammalian limb bud. Dev Biol. 2015 Oct 1;406(1):92-103
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory