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Ptprn Gene Detail
Summary
  • Symbol
    Ptprn
  • Name
    protein tyrosine phosphatase receptor type N
  • Synonyms
    IA-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:102765
    NCBI Gene: 19275
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:75223671-75241146 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 38.64 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    483 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_102765
 protein coding gene Chr1:75223671-75241437 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016182
 protein coding gene Chr1:75811104-75828463 (-)
A/J MGP_AJ_G0016165
 protein coding gene Chr1:73169751-73186890 (-)
AKR/J MGP_AKRJ_G0016122
 protein coding gene Chr1:75198899-75217705 (-)
BALB/cJ MGP_BALBcJ_G0016120
 protein coding gene Chr1:73230472-73247887 (-)
C3H/HeJ MGP_C3HHeJ_G0015951
 protein coding gene Chr1:75532707-75551156 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016573
 protein coding gene Chr1:78760226-78781436 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014294
 protein coding gene Chr1:68730821-68748568 (-)
CAST/EiJ MGP_CASTEiJ_G0015535
 protein coding gene Chr1:74874443-74893251 (-)
CBA/J MGP_CBAJ_G0015924
 protein coding gene Chr1:81320438-81337781 (-)
DBA/2J MGP_DBA2J_G0016025
 protein coding gene Chr1:72487763-72505058 (-)
FVB/NJ MGP_FVBNJ_G0016028
 protein coding gene Chr1:71688764-71708742 (-)
LP/J MGP_LPJ_G0016097
 protein coding gene Chr1:76935376-76955203 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016048
 protein coding gene Chr1:84678469-84695651 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016620
 protein coding gene Chr1:75269891-75287291 (-)
PWK/PhJ MGP_PWKPhJ_G0015322
 protein coding gene Chr1:71959556-71977836 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015100
 protein coding gene Chr1:74632311-74650674 (-)
WSB/EiJ MGP_WSBEiJ_G0015597
 protein coding gene Chr1:75081798-75099283 (-)



Homology
more
  • Human Ortholog
    PTPRN, protein tyrosine phosphatase receptor type N
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PTPRN, protein tyrosine phosphatase receptor type N
  • Synonyms
    IA-2, IA2, IA-2/PTP, ICA512, R-PTP-N
  • Links
    NCBI Gene ID: 5798
    neXtProt AC: NX_Q16849
    UniProt: Q16849

  • Chr Location
    2q35; chr2:219289623-219309648 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human PTPRN associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 2 genetic backgrounds
    11 phenotypes from multigenic genotypes
    37 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    1
  • Gene trapped
    1
  • Radiation induced
    2
  • Spontaneous
    1
  • Targeted
    5
  • Genomic Mutations
    4 involving Ptprn
  • Incidental Mutations
    Mutagenetix , APF
  • Find Mice (IMSR)
    38 strains or lines available
Mice homozygous for a disruption in this gene on a NOD background display insulitis and increased susceptibility to autoimmune diabetes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    39
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    810
  • Tissues
    38
  • cDNA Data
    36
  • Literature Summary
    7
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000026204 Ensembl Gene Model | MGI Sequence Detail 17476 C57BL/6J ±  kb
transcript ENSMUST00000027404 Ensembl | MGI Sequence Detail 3554 Not Applicable  
polypeptide ENSMUSP00000027404 Ensembl | MGI Sequence Detail 981 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    12 Sequences
  • Protein Ontology
    PR:000013474 receptor-type tyrosine-protein phosphatase-like N
    (term hierarchy)
  • EC
    3.1.3.48
  • InterPro Domains
    IPR016130 Protein-tyrosine phosphatase, active site
    IPR003595 Protein-tyrosine phosphatase, catalytic
    IPR029021 Protein-tyrosine phosphatase-like
    IPR021613 Protein-tyrosine phosphatase receptor IA-2 ectodomain
    IPR038112 Protein-tyrosine phosphatase receptor IA-2, ectodomain superfamily
    IPR033522 Receptor-type tyrosine-protein phosphatase-like N/N2
    IPR029403 RESP18 domain
    IPR000242 Tyrosine-specific protein phosphatase, PTPase domain
    IPR000387 Tyrosine-specific protein phosphatases domain
  • GlyGen
    Q60673 3 sites, 2 N-linked glycans (1 site), 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 37
    cDNA 37

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-19670
References
more
  • Summaries
    All 77
    Developmental Gene Expression 7
    Diseases 1
    Gene Ontology 11
    Phenotypes 37
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:334795 Sokanovic SJ, et al., Common and female-specific roles of protein tyrosine phosphatase receptors N and N2 in mice reproduction. Sci Rep. 2023 Jan 7;13(1):355
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory