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Gbp2 Gene Detail
Summary
  • Symbol
    Gbp2
  • Name
    guanylate binding protein 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:102772
    NCBI Gene: 14469
  • Alliance
    gene page
  • Transcription Start Sites
    21 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:142326424-142343769 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 66.69 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    609 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_102772
 protein coding gene Chr3:142326363-142343769 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027945
 protein coding gene Chr3:145835008-145854894 (+)
A/J MGP_AJ_G0027902
 protein coding gene Chr3:140661063-140675686 (+)
AKR/J MGP_AKRJ_G0027868
 protein coding gene Chr3:144411456-144428312 (+)
BALB/cJ MGP_BALBcJ_G0027914
 protein coding gene Chr3:140460824-140489325 (+)
C3H/HeJ MGP_C3HHeJ_G0027644
 protein coding gene Chr3:144726392-144746165 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028358
 protein coding gene Chr3:150889757-150908051 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025696
 protein coding gene Chr3:135889009-135907579 (+)
CAST/EiJ MGP_CASTEiJ_G0027100
 protein coding gene Chr3:144699563-144719064 (+)
CBA/J MGP_CBAJ_G0027621
 protein coding gene Chr3:156165982-156186369 (+)
DBA/2J MGP_DBA2J_G0027760
 protein coding gene Chr3:139826462-139844180 (+)
FVB/NJ MGP_FVBNJ_G0027727
 protein coding gene Chr3:137247437-137265893 (+)
LP/J MGP_LPJ_G0027870
 protein coding gene Chr3:147257159-147274823 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027759
 protein coding gene Chr3:164452243-164471067 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028416
 protein coding gene Chr3:144037035-144054446 (+)
PWK/PhJ MGP_PWKPhJ_G0026824
 protein coding gene Chr3:139595500-139671684 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026651
 protein coding gene Chr3:142126148-142188169 (+)
WSB/EiJ MGP_WSBEiJ_G0027179
 protein coding gene Chr3:144916115-144932092 (+)



Homology
more
  • Human Ortholog
    GBP1, guanylate binding protein 1
  • Vertebrate Orthologs
    6
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GBP1, guanylate binding protein 1
  • Synonyms
    hGBP1
  • Links
    NCBI Gene ID: 2633
    neXtProt AC: NX_P32455
    UniProt: P32455

  • Chr Location
    1p22.2; chr1:89051882-89065360 (-)  GRCh38
  • Human Ortholog
    GBP2, guanylate binding protein 2
  • Links
    NCBI Gene ID: 2634
    neXtProt AC: NX_P32456
    UniProt: P32456

  • Chr Location
    1p22.2; chr1:89106132-89150456 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    36 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene leads to increased susceptibility to chronic Toxoplasma gondii infection, characterized by an increased parasite burden in the brain.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    67
  • GO References
    18
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    804
  • Tissues
    98
  • cDNA Data
    119
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14469 NCBI Gene Model | MGI Sequence Detail 17346 C57BL/6J ±  kb
    transcript NM_010260 RefSeq | MGI Sequence Detail 2471 ZRU/MplStud  
    polypeptide Q9Z0E6 UniProt | EBI | MGI Sequence Detail 589 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • EC
      3.6.5.-
    • InterPro Domains
      IPR030386 GB1/RHD3-type guanine nucleotide-binding (G) domain
      IPR003191 Guanylate-binding protein/Atlastin, C-terminal
      IPR037684 Guanylate-binding protein, C-terminal
      IPR036543 Guanylate-binding protein, C-terminal domain superfamily
      IPR015894 Guanylate-binding protein, N-terminal
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
    • GlyGen
      Q9Z0E6 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 124
      Genomic 2
      cDNA 119
      Primer pair 2
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-19679
    References
    more
    • Summaries
      All 88
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 18
      Phenotypes 36
    • Earliest
      J:37849 Cheng YS, et al., Interferon-induced guanylate-binding proteins lack an N(T)KXD consensus motif and bind GMP in addition to GDP and GTP. Mol Cell Biol. 1991 Sep;11(9):4717-25
    • Latest
      J:350745 Marinho FV, et al., Guanylate-binding protein-5 is involved in inflammasome activation by bacterial DNA but only the cooperation of multiple GBPs accounts for control of Brucella abortus infection. Front Immunol. 2024;15:1341464
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory