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Vcan Gene Detail
Summary
  • Symbol
    Vcan
  • Name
    versican
  • Synonyms
    5430420N07Rik, Cspg2, DPEAAE, hdf, heart defect, PG-M
  • Feature Type
    protein coding gene
  • IDs
    MGI:102889
    NCBI Gene: 13003
  • Alliance
    gene page
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:89803431-89890628 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 45.50 cM
  • Mapping Data
    12 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2590 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    6
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_102889
 protein coding gene Chr13:89803429-89891146 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020800
 protein coding gene Chr13:90830659-90922606 (-)
A/J MGP_AJ_G0020754
 protein coding gene Chr13:87459767-87547867 (-)
AKR/J MGP_AKRJ_G0020727
 protein coding gene Chr13:90130048-90224195 (-)
BALB/cJ MGP_BALBcJ_G0020750
 protein coding gene Chr13:88126856-88214960 (-)
C3H/HeJ MGP_C3HHeJ_G0020544
 protein coding gene Chr13:89874132-89962426 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021187
 protein coding gene Chr13:93699105-93787869 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018755
 protein coding gene Chr13:83520754-83613851 (-)
CAST/EiJ MGP_CASTEiJ_G0020062
 protein coding gene Chr13:89063804-89152489 (-)
CBA/J MGP_CBAJ_G0020503
 protein coding gene Chr13:97337721-97428718 (-)
DBA/2J MGP_DBA2J_G0020628
 protein coding gene Chr13:87232057-87323311 (-)
FVB/NJ MGP_FVBNJ_G0020608
 protein coding gene Chr13:86080095-86167400 (-)
LP/J MGP_LPJ_G0020701
 protein coding gene Chr13:90977724-91068729 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020637
 protein coding gene Chr13:97698811-97810622 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021227
 protein coding gene Chr13:89540232-89628415 (-)
PWK/PhJ MGP_PWKPhJ_G0019815
 protein coding gene Chr13:85965310-86053369 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019638
 protein coding gene Chr13:85776990-85863960 (-)
WSB/EiJ MGP_WSBEiJ_G0020120
 protein coding gene Chr13:90016812-90105894 (-)



Homology
more
  • Human Ortholog
    VCAN, versican
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    VCAN, versican
  • Synonyms
    CSPG2, ERVR, GHAP, PG-M, WGN, WGN1
  • Links
    NCBI Gene ID: 1462
    neXtProt AC: NX_P13611
    UniProt: P13611

  • Chr Location
    5q14.2-q14.3; chr5:83471618-83582303 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human VCAN associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    53 phenotypes from 6 alleles in 9 genetic backgrounds
    2 phenotypes from multigenic genotypes
    5 images
    48 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for an insertional mutation exhibit anterior-posterior segmental defects of the heart, lack endocardial cushions of the conus and atrioventricular region, and die and around embryonic day 10.5. Homozygosity for a cleavage-resistant mutant leads to reduced embryonic survival, syndactyly and enhanced wound healing.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1497
  • Tissues
    374
  • cDNA Data
    40
  • Literature Summary
    133
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021614 Ensembl Gene Model | MGI Sequence Detail 87198 C57BL/6J ±  kb
    transcript ENSMUST00000109546 Ensembl | MGI Sequence Detail 12427 Not Applicable  
    polypeptide ENSMUSP00000105173 Ensembl | MGI Sequence Detail 3354 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 116
      Genomic 12
      cDNA 46
      Primer pair 50
      Other 8

      Microarray probesets 11
    Other
    Accession IDs
    less
    MGD-MRK-23722, MGI:1918683, MGI:894331
    References
    more
    • Summaries
      All 232
      Developmental Gene Expression 133
      Gene Ontology 12
      Phenotypes 48
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:358836 Ghotbi E, et al., Transcription factor KROX20 marks epithelial stem cell ancestors for hair follicle formation. J Clin Invest. 2024 Oct 3;134(23)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory