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Scx Gene Detail
Summary
  • Symbol
    Scx
  • Name
    scleraxis scleraxis bHLH transcription factor
  • Synonyms
    bHLHa41, Scl
  • Feature Type
    protein coding gene
  • IDs
    MGI:102934
    NCBI Gene: 20289
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:76341652-76343658 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 35.92 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    54 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_102934
 protein coding gene Chr15:76341594-76343668 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021993
 protein coding gene Chr15:76532162-76534192 (+)
A/J MGP_AJ_G0021951
 protein coding gene Chr15:73746430-73748460 (+)
AKR/J MGP_AKRJ_G0021934
 protein coding gene Chr15:75746403-75748433 (+)
BALB/cJ MGP_BALBcJ_G0021960
 protein coding gene Chr15:73774189-73776219 (+)
C3H/HeJ MGP_C3HHeJ_G0021732
 protein coding gene Chr15:75793882-75795912 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022400
 protein coding gene Chr15:79398895-79400925 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019929
 protein coding gene Chr15:70408009-70410041 (+)
CAST/EiJ MGP_CASTEiJ_G0021251
 protein coding gene Chr15:76596093-76598123 (+)
CBA/J MGP_CBAJ_G0021699
 protein coding gene Chr15:81902258-81904288 (+)
DBA/2J MGP_DBA2J_G0021824
 protein coding gene Chr15:73283503-73285533 (+)
FVB/NJ MGP_FVBNJ_G0021804
 protein coding gene Chr15:72338007-72340037 (+)
LP/J MGP_LPJ_G0021895
 protein coding gene Chr15:76630525-76632555 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021829
 protein coding gene Chr15:87237513-87239543 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022420
 protein coding gene Chr15:75997944-75999974 (+)
PWK/PhJ MGP_PWKPhJ_G0020992
 protein coding gene Chr15:73445619-73447649 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020832
 protein coding gene Chr15:75713225-75715256 (+)
WSB/EiJ MGP_WSBEiJ_G0021303
 protein coding gene Chr15:76101951-76103981 (+)



Homology
more
  • Human Ortholog
    SCX, scleraxis bHLH transcription factor
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SCX, scleraxis bHLH transcription factor
  • Synonyms
    bHLHa48, SCXA, SCXB
  • Links
    NCBI Gene ID: 642658
    neXtProt AC: NX_Q7RTU7
    UniProt: Q7RTU7

  • Chr Location
    8q24.3; chr8:144266453-144268481 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 5 alleles in 3 genetic backgrounds
    11 phenotypes from multigenic genotypes
    66 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted mutation develop normally up to E6.0-E6.5, but become arrested and fail to gastrulate and form mesodermal cells. In chimeric embryos, mutant cells are excluded from sclerotome-derived chondrogenic lineages but contribute to other cell types, including mesodermal tissues.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    56
  • GO References
    17
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1189
  • Tissues
    204
  • cDNA Data
    19
  • Literature Summary
    127
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000034161 Ensembl Gene Model | MGI Sequence Detail 2007 C57BL/6J ±  kb
    transcript ENSMUST00000043089 Ensembl | MGI Sequence Detail 1035 Not Applicable  
    polypeptide ENSMUSP00000043668 Ensembl | MGI Sequence Detail 207 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000014546 basic helix-loop-helix transcription factor scleraxis
      (term hierarchy)
    • InterPro Domains
      IPR050283 E-box Binding Transcriptional Regulators
      IPR036638 Helix-loop-helix DNA-binding domain superfamily
      IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
    Molecular
    Reagents
    less
    • All nucleic 47
      cDNA 21
      Primer pair 7
      Other 19

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-23768, MGI:2146261
    References
    more
    • Summaries
      All 217
      Developmental Gene Expression 127
      Diseases 1
      Gene Ontology 17
      Phenotypes 66
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:357740 Sorsby M, et al., The role of GDF5 in regulating enthesopathy development in the Hyp mouse model of XLH. J Bone Miner Res. 2024 Aug 21;39(8):1162-1173
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory