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Txk Gene Detail
Summary
  • Symbol
    Txk
  • Name
    TXK tyrosine kinase
  • Synonyms
    A130089B16Rik, Btkl, PTK4, Rlk
  • Feature Type
    protein coding gene
  • IDs
    MGI:102960
    NCBI Gene: 22165
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:72853321-72910120 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 38.44 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2071 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_102960
 protein coding gene Chr5:72853321-72910337 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029616
 protein coding gene Chr5:72637360-72701306 (-)
A/J MGP_AJ_G0029584
 protein coding gene Chr5:69931496-69988926 (-)
AKR/J MGP_AKRJ_G0029532
 protein coding gene Chr5:72169335-72229232 (-)
BALB/cJ MGP_BALBcJ_G0029592
 protein coding gene Chr5:70626483-70683255 (-)
C3H/HeJ MGP_C3HHeJ_G0029317
 protein coding gene Chr5:72546384-72609959 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030047
 protein coding gene Chr5:75629756-75690818 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027289
 protein coding gene Chr5:65638367-65695655 (-)
CAST/EiJ MGP_CASTEiJ_G0028726
 protein coding gene Chr5:71644197-71708734 (-)
CBA/J MGP_CBAJ_G0029285
 protein coding gene Chr5:78063896-78130755 (-)
DBA/2J MGP_DBA2J_G0029432
 protein coding gene Chr5:69973877-70035877 (-)
FVB/NJ MGP_FVBNJ_G0029392
 protein coding gene Chr5:69149718-69206399 (-)
LP/J MGP_LPJ_G0029516
 protein coding gene Chr5:73093286-73152351 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029418
 protein coding gene Chr5:81422397-81481664 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030081
 protein coding gene Chr5:71743858-71801980 (-)
PWK/PhJ MGP_PWKPhJ_G0028448
 protein coding gene Chr5:68958813-69017937 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028281
 protein coding gene Chr5:71079351-71136709 (-)
WSB/EiJ MGP_WSBEiJ_G0028806
 protein coding gene Chr5:72026668-72089705 (-)



Homology
more
  • Human Ortholog
    TXK, TXK tyrosine kinase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TXK, TXK tyrosine kinase
  • Synonyms
    BTKL, PSCTK5, PTK4, RLK, TKL
  • Links
    NCBI Gene ID: 7294
    neXtProt AC: NX_P42681
    UniProt: P42681

  • Chr Location
    4p12; chr4:48066393-48134250 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    8 phenotypes from multigenic genotypes
    41 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in increased susceptibility to parasitic (Toxoplasma gondii) infection and decreased cytokine secretion in stimulated splenocytes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    29
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    840
  • Tissues
    29
  • cDNA Data
    37
  • Literature Summary
    4
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000054892 Ensembl Gene Model | MGI Sequence Detail 56800 C57BL/6J ±  kb
transcript ENSMUST00000169534 Ensembl | MGI Sequence Detail 2344 Not Applicable  
polypeptide ENSMUSP00000129397 Ensembl | MGI Sequence Detail 527 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 40
    Genomic 1
    cDNA 37
    Primer pair 2

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-23796, MGI:2444219
References
more
  • Summaries
    All 82
    Developmental Gene Expression 4
    Gene Ontology 9
    Phenotypes 41
  • Earliest
    J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory