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Ccr7 Gene Detail
Summary
  • Symbol
    Ccr7
  • Name
    C-C motif chemokine receptor 7
  • Synonyms
    CD197, Cmkbr7, EBI1, Ebi1h
  • Feature Type
    protein coding gene
  • IDs
    MGI:103011
    NCBI Gene: 12775
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:99035025-99045903 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 62.92 cM, cytoband D
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    390 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_103011
 protein coding gene Chr11:99035022-99045903 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019083
 protein coding gene Chr11:101787624-101800058 (-)
A/J MGP_AJ_G0019051
 protein coding gene Chr11:97509501-97520378 (-)
AKR/J MGP_AKRJ_G0019021
 protein coding gene Chr11:100530154-100541034 (-)
BALB/cJ MGP_BALBcJ_G0019025
 protein coding gene Chr11:98001769-98013129 (-)
C3H/HeJ MGP_C3HHeJ_G0018838
 protein coding gene Chr11:100677653-100689266 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019476
 protein coding gene Chr11:104917870-104930048 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017108
 protein coding gene Chr11:95068523-95079444 (-)
CAST/EiJ MGP_CASTEiJ_G0018392
 protein coding gene Chr11:101676308-101688332 (-)
CBA/J MGP_CBAJ_G0018809
 protein coding gene Chr11:109276842-109293343 (-)
DBA/2J MGP_DBA2J_G0018917
 protein coding gene Chr11:97068335-97079488 (-)
FVB/NJ MGP_FVBNJ_G0018906
 protein coding gene Chr11:96586735-96598215 (-)
LP/J MGP_LPJ_G0018987
 protein coding gene Chr11:102261072-102271999 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018933
 protein coding gene Chr11:108981440-108992252 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019516
 protein coding gene Chr11:100889263-100899992 (-)
PWK/PhJ MGP_PWKPhJ_G0018163
 protein coding gene Chr11:98128574-98139576 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017952
 protein coding gene Chr11:100649021-100659946 (-)
WSB/EiJ MGP_WSBEiJ_G0018441
 protein coding gene Chr11:100858578-100871638 (-)



Homology
more
  • Human Ortholog
    CCR7, C-C motif chemokine receptor 7
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CCR7, C-C motif chemokine receptor 7
  • Synonyms
    BLR2, CC-CKR-7, CCR-7, CD197, CDw197, CMKBR7, EBI1
  • Links
    NCBI Gene ID: 1236
    neXtProt AC: NX_P32248
    UniProt: P32248

  • Chr Location
    17q21.2; chr17:40553769-40565472 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Ccr7 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    50 phenotypes from 4 alleles in 8 genetic backgrounds
    3 phenotypes from multigenic genotypes
    259 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mice exhibit an impaired primary immune response. Dendritic cells, B, T and T regulatory cells show impaired migration to the lymph nodes and secondary lymph organs exhibit morphological abnormalities. Lymphocytic infiltrates to the pancreas, lung and stomach are observed in aged mice.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    78
  • GO References
    24
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    857
  • Tissues
    92
  • cDNA Data
    22
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12775 NCBI Gene Model | MGI Sequence Detail 10879 C57BL/6J ±  kb
    transcript NM_007719 RefSeq | MGI Sequence Detail 1975 C57BL/6  
    polypeptide P47774 UniProt | EBI | MGI Sequence Detail 378 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 26
      cDNA 22
      Primer pair 3
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-23848
    References
    more
    • Summaries
      All 368
      Developmental Gene Expression 8
      Diseases 1
      Gene Ontology 24
      Phenotypes 259
    • Earliest
      J:21104 Schweickart VL, et al., Cloning of human and mouse EBI1, a lymphoid-specific G-protein-coupled receptor encoded on human chromosome 17q12-q21.2. Genomics. 1994 Oct;23(3):643-50
    • Latest
      J:351006 Zhivaki D, et al., Correction of age-associated defects in dendritic cells enables CD4(+) T cells to eradicate tumors. Cell. 2024 Jun 12;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory