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Stat6 Gene Detail
Summary
  • Symbol
    Stat6
  • Name
    signal transducer and activator of transcription 6
  • Feature Type
    protein coding gene
  • IDs
    MGI:103034
    NCBI Gene: 20852
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:127478855-127496826 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 74.59 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    460 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_103034
 protein coding gene Chr10:127478855-127496856 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017828
 protein coding gene Chr10:131268808-131286650 (+)
A/J MGP_AJ_G0017803
 protein coding gene Chr10:126013804-126031952 (+)
AKR/J MGP_AKRJ_G0017766
 protein coding gene Chr10:129733801-129751603 (+)
BALB/cJ MGP_BALBcJ_G0017767
 protein coding gene Chr10:126415177-126434182 (+)
C3H/HeJ MGP_C3HHeJ_G0017591
 protein coding gene Chr10:129885484-129906644 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018222
 protein coding gene Chr10:135714923-135734568 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015902
 protein coding gene Chr10:119997916-120015832 (+)
CAST/EiJ MGP_CASTEiJ_G0017151
 protein coding gene Chr10:130548409-130570989 (+)
CBA/J MGP_CBAJ_G0017560
 protein coding gene Chr10:141187108-141208523 (+)
DBA/2J MGP_DBA2J_G0017666
 protein coding gene Chr10:125088534-125106621 (+)
FVB/NJ MGP_FVBNJ_G0017661
 protein coding gene Chr10:124030356-124048995 (+)
LP/J MGP_LPJ_G0017740
 protein coding gene Chr10:131843251-131861447 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017689
 protein coding gene Chr10:143870833-143888819 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018262
 protein coding gene Chr10:129805779-129825825 (+)
PWK/PhJ MGP_PWKPhJ_G0016936
 protein coding gene Chr10:125294810-125314308 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016728
 protein coding gene Chr10:128834439-128857409 (+)
WSB/EiJ MGP_WSBEiJ_G0017212
 protein coding gene Chr10:130025630-130048191 (+)



Homology
more
  • Human Ortholog
    STAT6, signal transducer and activator of transcription 6
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    STAT6, signal transducer and activator of transcription 6
  • Synonyms
    D12S1644, HIES6, IL-4-STAT, STAT6B, STAT6C
  • Links
    NCBI Gene ID: 6778
    neXtProt AC: NX_P42226
    UniProt: P42226

  • Chr Location
    12q13.3; chr12:57095408-57132139 (-)  GRCh38
Human Diseases
more
  • Diseases
    5 with human STAT6 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    70 phenotypes from 3 alleles in 10 genetic backgrounds
    42 phenotypes from multigenic genotypes
    498 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit impaired IL4 responses, including anti-IgM stimulated B cell proliferation, class switching to IgE, contact sensitivity, and Th2 cytokine production, and show increased resistance to certain infections.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    67
  • GO References
    23
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    877
  • Tissues
    57
  • cDNA Data
    78
  • Literature Summary
    14
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000002147 Ensembl Gene Model | MGI Sequence Detail 17972 C57BL/6J ±  kb
    transcript ENSMUST00000092074 Ensembl | MGI Sequence Detail 3775 Not Applicable  
    polypeptide ENSMUSP00000089708 Ensembl | MGI Sequence Detail 837 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000002093 signal transducer and activator of transcription 6
      (term hierarchy)
    • InterPro Domains
      IPR008967 p53-like transcription factor, DNA-binding domain superfamily
      IPR000980 SH2 domain
      IPR036860 SH2 domain superfamily
      IPR048988 Signal transducer and activator of transcription, linker domain
      IPR028187 STAT6, C-terminal
      IPR035857 STAT6, SH2 domain
      IPR013800 STAT transcription factor, all-alpha domain
      IPR015988 STAT transcription factor, coiled coil
      IPR013801 STAT transcription factor, DNA-binding
      IPR012345 STAT transcription factor, DNA-binding, N-terminal
      IPR036535 STAT transcription factor, N-terminal domain superfamily
      IPR013799 STAT transcription factor, protein interaction
      IPR001217 Transcription factor STAT
    • GlyGen
      P52633 9 sites, 1 O-linked glycan (9 sites)
    Molecular
    Reagents
    less
    • All nucleic 83
      Genomic 2
      cDNA 78
      Primer pair 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-23872
    References
    more
    • Summaries
      All 636
      Developmental Gene Expression 14
      Gene Ontology 23
      Phenotypes 498
    • Earliest
      J:29554 Hou J, et al., An interleukin-4-induced transcription factor: IL-4 Stat. Science. 1994 Sep 16;265(5179):1701-6
    • Latest
      J:358465 Kabil A, et al., Microbial intestinal dysbiosis drives long-term allergic susceptibility by sculpting an ILC2-B1 cell-innate IgE axis. J Allergy Clin Immunol. 2024 Nov;154(5):1260-1276.e9
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory