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Stat3 Gene Detail
Summary
  • Symbol
    Stat3
  • Name
    signal transducer and activator of transcription 3
  • Synonyms
    1110034C02Rik, Aprf
  • Feature Type
    protein coding gene
  • IDs
    MGI:103038
    NCBI Gene: 20848
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:100777632-100830447 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 63.82 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1285 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_103038
 protein coding gene Chr11:100775924-100830447 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019173
 protein coding gene Chr11:103670217-103729564 (-)
A/J MGP_AJ_G0019141
 protein coding gene Chr11:99341335-99394212 (-)
AKR/J MGP_AKRJ_G0019110
 protein coding gene Chr11:102428812-102486235 (-)
BALB/cJ MGP_BALBcJ_G0019115
 protein coding gene Chr11:99827722-99881630 (-)
C3H/HeJ MGP_C3HHeJ_G0018924
 protein coding gene Chr11:102598307-102653400 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019564
 protein coding gene Chr11:106877999-106933118 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017190
 protein coding gene Chr11:96759560-96813098 (-)
CAST/EiJ MGP_CASTEiJ_G0018478
 protein coding gene Chr11:103577768-103640821 (-)
CBA/J MGP_CBAJ_G0018893
 protein coding gene Chr11:111348354-111403768 (-)
DBA/2J MGP_DBA2J_G0019005
 protein coding gene Chr11:98875632-98930018 (-)
FVB/NJ MGP_FVBNJ_G0018995
 protein coding gene Chr11:98417198-98474452 (-)
LP/J MGP_LPJ_G0019074
 protein coding gene Chr11:104227186-104284095 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019026
 protein coding gene Chr11:110921950-110979896 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019602
 protein coding gene Chr11:102743495-102797491 (-)
PWK/PhJ MGP_PWKPhJ_G0018241
 protein coding gene Chr11:99923798-99975789 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018033
 protein coding gene Chr11:102485251-102537204 (-)
WSB/EiJ MGP_WSBEiJ_G0018527
 protein coding gene Chr11:102741286-102797251 (-)



Homology
more
  • Human Ortholog
    STAT3, signal transducer and activator of transcription 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    STAT3, signal transducer and activator of transcription 3
  • Synonyms
    ADMIO, ADMIO1, APRF, HIES
  • Links
    NCBI Gene ID: 6774
    neXtProt AC: NX_P40763
    UniProt: P40763

  • Chr Location
    17q21.2; chr17:42313324-42388568 (-)  GRCh38
Human Diseases
more
  • Diseases
    5 with Stat3 mouse models; 22 with human STAT3 associations

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 1 model
      
IDs
 View 1 model
IDs
 View 3 models
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    5 with disease annotations
  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    204 phenotypes from 16 alleles in 27 genetic backgrounds
    37 phenotypes from multigenic genotypes
    7 images
    649 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations die at embryonic day 6.5-7.5. Conditional, tissue specific mutants are variably viable and show diverse defects including obesity, diabetes, thermal dysregulation and infertility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    243
  • GO References
    73
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1323
  • Tissues
    288
  • cDNA Data
    368
  • Literature Summary
    122
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20848 NCBI Gene Model | MGI Sequence Detail 52816 C57BL/6J ±  kb
    transcript NM_213659 RefSeq | MGI Sequence Detail 4390 C57BL/6  
    polypeptide P42227 UniProt | EBI | MGI Sequence Detail 770 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000002089 signal transducer and activator of transcription 3
      (term hierarchy)
    • PDB
      1BG1, 3CWG, 4E68, 4ZIA
    • InterPro Domains
      IPR008967 p53-like transcription factor, DNA-binding domain superfamily
      IPR000980 SH2 domain
      IPR036860 SH2 domain superfamily
      IPR048988 Signal transducer and activator of transcription, linker domain
      IPR035855 STAT3, SH2 domain
      IPR013800 STAT transcription factor, all-alpha domain
      IPR015988 STAT transcription factor, coiled coil
      IPR013801 STAT transcription factor, DNA-binding
      IPR012345 STAT transcription factor, DNA-binding, N-terminal
      IPR036535 STAT transcription factor, N-terminal domain superfamily
      IPR013799 STAT transcription factor, protein interaction
      IPR001217 Transcription factor STAT
    • GlyGen
      P42227 5 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (4 sites)
    Molecular
    Reagents
    less
    • All nucleic 379
      Genomic 2
      cDNA 370
      Primer pair 7

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-23900, MGI:1915983, MGI:2144497
    References
    more
    • Summaries
      All 1328
      Developmental Gene Expression 122
      Diseases 6
      Gene Ontology 73
      Phenotypes 649
    • Earliest
      J:65032 Guo L, et al., Targeting expression of keratinocyte growth factor to keratinocytes elicits striking changes in epithelial differentiation in transgenic mice. EMBO J. 1993 Mar;12(3):973-86
    • Latest
      J:357561 Xu W, et al., Arsenic up-regulates PD-L1 and enhances lung tumorigenesis through activation of STAT3 in alveolar epithelial type 2 cells. Toxicol Appl Pharmacol. 2024 Jan;482:116787
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory