Stat1 MGI Mouse Gene Detail - MGI:103063 - signal transducer and activator of transcription 1

Symbol

Stat1
Name

signal transducer and activator of transcription 1
Synonyms

2010005J02Rik

Feature Type

protein coding gene
IDs

MGI:103063
NCBI Gene: 20846
Alliance

gene page
Transcription Start Sites

29 TSS

Sequence Map

Chr1:52158599-52201024 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 26.81 cM
Mapping Data

6 experiments

SNPs within 2kb

1470 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_103063	protein coding gene	Chr1:52158588-52201024 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016006	protein coding gene	Chr1:51628850-51671784 (+)
A/J	MGP_AJ_G0015988	protein coding gene	Chr1:49900289-49942002 (+)
AKR/J	MGP_AKRJ_G0015944	protein coding gene	Chr1:50952889-50994736 (+)
BALB/cJ	MGP_BALBcJ_G0015945	protein coding gene	Chr1:49715568-49757744 (+)
C3H/HeJ	MGP_C3HHeJ_G0015777	protein coding gene	Chr1:51359021-51402478 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016396	protein coding gene	Chr1:53800977-53842750 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014128	protein coding gene	Chr1:41915041-41956718 (-)
CAST/EiJ	MGP_CASTEiJ_G0015358	protein coding gene	Chr1:50840041-50881813 (+)
CBA/J	MGP_CBAJ_G0015748	protein coding gene	Chr1:55235992-55277729 (+)
DBA/2J	MGP_DBA2J_G0015849	protein coding gene	Chr1:49151562-49193563 (+)
FVB/NJ	MGP_FVBNJ_G0015851	protein coding gene	Chr1:48616606-48658312 (+)
LP/J	MGP_LPJ_G0015920	protein coding gene	Chr1:52125262-52166698 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0015871	protein coding gene	Chr1:58262387-58305563 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016444	protein coding gene	Chr1:51084199-51125904 (+)
PWK/PhJ	MGP_PWKPhJ_G0015144	protein coding gene	Chr1:49032952-49074196 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0014924	protein coding gene	Chr1:50737870-50779590 (+)
WSB/EiJ	MGP_WSBEiJ_G0015421	protein coding gene	Chr1:50889963-50936974 (+)

Human Ortholog

STAT1, signal transducer and activator of transcription 1

Vertebrate Orthologs

5

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

STAT1, signal transducer and activator of transcription 1
Synonyms

CANDF7, IMD31A, IMD31B, IMD31C, ISGF-3, STAT91
Links

HGNC:11362

NCBI Gene ID: 6772

neXtProt AC: NX_P42224

UniProt: P42224
Chr Location

2q32.2; chr2:190908460-191020960 (-) GRCh38

MGI Vertebrate Homology

Stat1 stringent orthology
1 human;1 mouse;2 rat;2 zebrafish
HCOP

vertebrate homology predictions: STAT1
Gene Tree

Stat1

Diseases

2 with Stat1 mouse models; 6 with human STAT1 associations

Human Disease

Mouse Models

breast cancer

IDs

View 1 model

severe acute respiratory syndrome

IDs

View 1 model

IDs

IDs

IDs

IDs

IDs

prostate adenocarcinoma

IDs

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

2 with disease annotations

References

3 with disease annotations

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Phenotype Summary

92 phenotypes from 15 alleles in 23 genetic backgrounds
30 phenotypes from multigenic genotypes
546 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

39
Chemically induced (ENU)

7
Chemically induced (other)

1
Endonuclease-mediated

9
Radiation induced

1
Targeted

21
Genomic Mutations

2 involving Stat1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

74 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for targeted null mutations are largely unresponsive to interferon, fail to thrive, are susceptible to viral diseases and cutaneous leishmaniasis, and show excess osteoclastogenesis leading to increased bone mass.

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All GO Annotations

121
GO References

28

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

936
Tissues

126
cDNA Data

20
Literature Summary

47

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase stat1

ZFIN stat1a, stat1b

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All Sequences

87
RefSeq

18
UniProt

11
CCDS

CCDS56628.1, CCDS78581.1

Ensembl

ENSMUSG00000026104 (Evidence)
NCBI Gene

20846

			Length	Strain/Species	Flank
genomic	ENSMUSG00000026104	Ensembl Gene Model \| MGI Sequence Detail	42426	C57BL/6J	± kb
transcript	ENSMUST00000186057	Ensembl \| MGI Sequence Detail	3998	Not Applicable
polypeptide	ENSMUSP00000141132	Ensembl \| MGI Sequence Detail	755	Not Applicable

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UniProt

11 Sequences
Protein Ontology

PR:000002087 signal transducer and activator of transcription 1

(term hierarchy)
InterPro Domains

IPR008967 p53-like transcription factor, DNA-binding domain superfamily

IPR000980 SH2 domain

IPR036860 SH2 domain superfamily

IPR022752 Signal transducer and activation of transcription 1, TAZ2 binding domain, C-terminal

IPR048988 Signal transducer and activator of transcription, linker domain

IPR038295 STAT1, C-terminal domain superfamily

IPR035859 STAT1, SH2 domain

IPR013800 STAT transcription factor, all-alpha domain

IPR015988 STAT transcription factor, coiled coil

IPR013801 STAT transcription factor, DNA-binding

IPR012345 STAT transcription factor, DNA-binding, N-terminal

IPR036535 STAT transcription factor, N-terminal domain superfamily

IPR013799 STAT transcription factor, protein interaction

IPR001217 Transcription factor STAT
GlyGen

P42225 1 site, 1 O-linked glycan (1 site)

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All nucleic 37

Genomic 7

cDNA 25

Primer pair 5

Microarray probesets 6

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MGD-MRK-23925, MGI:1923977, MGI:2138078

Summaries

All 829

Developmental Gene Expression 47

Diseases 3

Gene Ontology 28

Phenotypes 546
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:354587 Nedomova M, et al., DDI2 protease controls embryonic development and inflammation via TCF11/NRF1. iScience. 2024 Oct 18;27(10):110893

TSS for Stat1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr6645	Chr1:52158630-52158658 (+)	45 bp
Tssr6646	Chr1:52158693-52158716 (+)	106 bp
Tssr6647	Chr1:52158721-52158748 (+)	136 bp
Tssr81	Chr1:52159032-52159055 (+)	445 bp
Tssr6648	Chr1:52159055-52159094 (+)	476 bp
Tssr6649	Chr1:52162268-52162392 (+)	3,731 bp
Tssr6650	Chr1:52165667-52165724 (+)	7,097 bp
Tssr6651	Chr1:52166890-52166903 (+)	8,298 bp
Tssr6652	Chr1:52171705-52171720 (+)	13,114 bp
Tssr6653	Chr1:52171747-52171758 (+)	13,154 bp
Tssr6654	Chr1:52176545-52176561 (+)	17,954 bp
Tssr6655	Chr1:52178406-52178427 (+)	19,818 bp
Tssr6656	Chr1:52178433-52178453 (+)	19,844 bp
Tssr6657	Chr1:52188055-52188083 (+)	29,470 bp
Tssr6658	Chr1:52189769-52189804 (+)	31,188 bp
Tssr6659	Chr1:52190007-52190017 (+)	31,413 bp
Tssr6660	Chr1:52190093-52190103 (+)	31,499 bp
Tssr6661	Chr1:52190165-52190176 (+)	31,572 bp
Tssr6662	Chr1:52191450-52191462 (+)	32,857 bp
Tssr6663	Chr1:52191484-52191502 (+)	32,894 bp
Tssr6664	Chr1:52191510-52191517 (+)	32,915 bp
Tssr6665	Chr1:52192994-52193009 (+)	34,403 bp
Tssr6666	Chr1:52194256-52194271 (+)	35,665 bp
Tssr6667	Chr1:52194273-52194290 (+)	35,683 bp
Tssr6668	Chr1:52194296-52194321 (+)	35,710 bp
Tssr6669	Chr1:52194357-52194376 (+)	35,768 bp
Tssr6670	Chr1:52194377-52194411 (+)	35,795 bp
Tssr6671	Chr1:52194442-52194471 (+)	35,858 bp
Tssr6672	Chr1:52194500-52194518 (+)	35,910 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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