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Btn1a1 Gene Detail
Summary
  • Symbol
    Btn1a1
  • Name
    butyrophilin, subfamily 1, member A1
  • Synonyms
    Btn
  • Feature Type
    protein coding gene
  • IDs
    MGI:103118
    NCBI Gene: 12231
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:23641162-23650071 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 9.72 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    290 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_103118
 protein coding gene Chr13:23641154-23650084 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020342
 protein coding gene Chr13:20863267-20872199 (-)
A/J MGP_AJ_G0020299
 protein coding gene Chr13:20493517-20502505 (-)
AKR/J MGP_AKRJ_G0020271
 protein coding gene Chr13:20733989-20742901 (-)
BALB/cJ MGP_BALBcJ_G0020285
 protein coding gene Chr13:20484635-20493544 (-)
C3H/HeJ MGP_C3HHeJ_G0020094
 protein coding gene Chr13:20816360-20825257 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020730
 protein coding gene Chr13:21624111-21633032 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018314
 protein coding gene Chr13:19294942-19304013 (-)
CAST/EiJ MGP_CASTEiJ_G0019616
 protein coding gene Chr13:20502607-20511524 (-)
CBA/J MGP_CBAJ_G0020045
 protein coding gene Chr13:22463644-22472903 (-)
DBA/2J MGP_DBA2J_G0020171
 protein coding gene Chr13:20063360-20072252 (-)
FVB/NJ MGP_FVBNJ_G0020159
 protein coding gene Chr13:19682653-19691560 (-)
LP/J MGP_LPJ_G0020244
 protein coding gene Chr13:21189375-21198304 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020189
 protein coding gene Chr13:22782393-22792221 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020760
 protein coding gene Chr13:20586761-20595656 (-)
PWK/PhJ MGP_PWKPhJ_G0019371
 protein coding gene Chr13:20050622-20059737 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019182
 protein coding gene Chr13:19384259-19394452 (-)
WSB/EiJ MGP_WSBEiJ_G0019672
 protein coding gene Chr13:20715776-20724662 (-)



Homology
more
  • Human Ortholog
    BTN1A1, butyrophilin subfamily 1 member A1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BTN1A1, butyrophilin subfamily 1 member A1
  • Synonyms
    BT, BTN, BTN1
  • Links
    NCBI Gene ID: 696
    neXtProt AC: NX_Q13410
    UniProt: Q13410

  • Chr Location
    6p22.2; chr6:26500303-26510425 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display impaired lactation and abnormal lipid accumulation in the mammary gland.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    6
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    723
  • Tissues
    14
  • cDNA Data
    53
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000000706 Ensembl Gene Model | MGI Sequence Detail 8910 C57BL/6J ±  kb
    transcript ENSMUST00000041674 Ensembl | MGI Sequence Detail 3423 Not Applicable  
    polypeptide ENSMUSP00000041013 Ensembl | MGI Sequence Detail 524 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 63
      Genomic 5
      cDNA 55
      Other 3

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-23982
    References
    more
    • Summaries
      All 52
      Developmental Gene Expression 5
      Gene Ontology 3
      Phenotypes 18
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:321944 Jeong J, et al., The butyrophilin 1a1 knockout mouse revisited: Ablation of Btn1a1 leads to concurrent cell death and renewal in the mammary epithelium during lactation. FASEB Bioadv. 2021 Dec;3(12):971-997
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory