About   Help   FAQ
Mmp7 Gene Detail
Summary
  • Symbol
    Mmp7
  • Name
    matrix metallopeptidase 7
  • Synonyms
    MAT, matrilysin
  • Feature Type
    protein coding gene
  • IDs
    MGI:103189
    NCBI Gene: 17393
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:7692095-7699587 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 2.46 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    326 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_103189
 protein coding gene Chr9:7692091-7699587 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034327
 protein coding gene Chr9:4552332-4559835 (+)
A/J MGP_AJ_G0034305
 protein coding gene Chr9:4657846-4665341 (+)
AKR/J MGP_AKRJ_G0034233
 protein coding gene Chr9:4527631-4535156 (+)
BALB/cJ MGP_BALBcJ_G0034299
 protein coding gene Chr9:4395886-4403381 (+)
C3H/HeJ MGP_C3HHeJ_G0034010
 protein coding gene Chr9:4721101-4728596 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034821
 protein coding gene Chr9:4726768-4734263 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031759
 protein coding gene Chr9:3916465-3923961 (+)
CAST/EiJ MGP_CASTEiJ_G0033338
 protein coding gene Chr9:4749675-4758308 (+)
CBA/J MGP_CBAJ_G0033983
 protein coding gene Chr9:4829201-4836696 (+)
DBA/2J MGP_DBA2J_G0034140
 protein coding gene Chr9:4534662-4542157 (+)
FVB/NJ MGP_FVBNJ_G0034085
 protein coding gene Chr9:4313911-4321406 (+)
LP/J MGP_LPJ_G0034226
 protein coding gene Chr9:4605856-4613375 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034129
 protein coding gene Chr9:5593062-5600557 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034840
 protein coding gene Chr9:4527403-4534898 (+)
PWK/PhJ MGP_PWKPhJ_G0033041
 protein coding gene Chr9:4661140-4668663 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032879
 protein coding gene Chr9:4773998-4781490 (+)
WSB/EiJ MGP_WSBEiJ_G0033453
 protein coding gene Chr9:4534641-4542191 (+)



Homology
more
  • Human Ortholog
    MMP7, matrix metallopeptidase 7
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MMP7, matrix metallopeptidase 7
  • Synonyms
    MMP-7, MPSL1, PUMP-1
  • Links
    NCBI Gene ID: 4316
    neXtProt AC: NX_P09237
    UniProt: P09237

  • Chr Location
    11q22.2; chr11:102520508-102530750 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 1 allele in 4 genetic backgrounds
    6 phenotypes from multigenic genotypes
    55 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased sensitivity to induced colitis and corneal wound neovascularization, decreased sensitivity to myocardial infarction and pancreatic duct ligation, impaired tracheal wound healing, and altered tumor susceptibility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    30
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    981
  • Tissues
    90
  • cDNA Data
    17
  • Literature Summary
    27
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17393 NCBI Gene Model | MGI Sequence Detail 7493 C57BL/6J ±  kb
    transcript NM_010810 RefSeq | MGI Sequence Detail 1065 C57BL/6  
    polypeptide Q10738 UniProt | EBI | MGI Sequence Detail 264 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 34
      Genomic 7
      cDNA 18
      Primer pair 9

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-24057
    References
    more
    • Summaries
      All 132
      Developmental Gene Expression 27
      Gene Ontology 9
      Phenotypes 55
    • Earliest
      J:26885 Wilson CL, et al., The metalloproteinase matrilysin is preferentially expressed by epithelial cells in a tissue-restricted pattern in the mouse. Mol Biol Cell. 1995 Jul;6(7):851-69
    • Latest
      J:343798 Cheng T, et al., Aberrant centrosome biogenesis disrupts nephron and collecting duct progenitor growth and fate resulting in fibrocystic kidney disease. Development. 2023 Dec 15;150(24)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory