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Cdc25a Gene Detail
Summary
  • Symbol
    Cdc25a
  • Name
    cell division cycle 25A
  • Synonyms
    D9Ertd393e
  • Feature Type
    protein coding gene
  • IDs
    MGI:103198
    NCBI Gene: 12530
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:109704647-109722963 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 59.81 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    493 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_103198
 protein coding gene Chr9:109704545-109722963 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035339
 protein coding gene Chr9:111980711-111998954 (+)
A/J MGP_AJ_G0035320
 protein coding gene Chr9:107925152-107943596 (+)
AKR/J MGP_AKRJ_G0035251
 protein coding gene Chr9:110596707-110615166 (+)
BALB/cJ MGP_BALBcJ_G0035315
 protein coding gene Chr9:107664917-107683453 (+)
C3H/HeJ MGP_C3HHeJ_G0035023
 protein coding gene Chr9:111066960-111085407 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035837
 protein coding gene Chr9:115020631-115038947 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032723
 protein coding gene Chr9:105158450-105175417 (+)
CAST/EiJ MGP_CASTEiJ_G0034329
 protein coding gene Chr9:110883309-110900995 (+)
CBA/J MGP_CBAJ_G0034990
 protein coding gene Chr9:119295505-119317148 (+)
DBA/2J MGP_DBA2J_G0035149
 protein coding gene Chr9:107385694-107404145 (+)
FVB/NJ MGP_FVBNJ_G0035096
 protein coding gene Chr9:106215187-106233511 (+)
LP/J MGP_LPJ_G0035228
 protein coding gene Chr9:112287571-112305826 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035136
 protein coding gene Chr9:120668818-120687731 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035857
 protein coding gene Chr9:110908707-110927024 (+)
PWK/PhJ MGP_PWKPhJ_G0034036
 protein coding gene Chr9:107608007-107626598 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033871
 protein coding gene Chr9:110992121-111010050 (+)
WSB/EiJ MGP_WSBEiJ_G0034450
 protein coding gene Chr9:110793253-110811491 (+)



Homology
more
  • Human Ortholog
    CDC25A, cell division cycle 25A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CDC25A, cell division cycle 25A
  • Synonyms
    CDC25A2
  • Links
    NCBI Gene ID: 993
    neXtProt AC: NX_P30304
    UniProt: P30304

  • Chr Location
    3p21.31; chr3:48157146-48188417 (-)  GRCh38
Human Diseases
more
  • Diseases
    3 with human CDC25A associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 6 alleles in 7 genetic backgrounds
    19 phenotypes from multigenic genotypes
    5 images
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a spontaneous mutation exhibit elevated levels of early erythroid progenitor cell cycling but erythropoiesis is normally unaffected. Homozygous deletion of this gene is lethal and male heterozygotes display decreased vertebral trabecular bone.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    770
  • Tissues
    51
  • cDNA Data
    92
  • Literature Summary
    13
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032477 Ensembl Gene Model | MGI Sequence Detail 18317 C57BL/6J ±  kb
    transcript ENSMUST00000094324 Ensembl | MGI Sequence Detail 3632 Not Applicable  
    polypeptide ENSMUSP00000091882 Ensembl | MGI Sequence Detail 514 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 99
      cDNA 95
      Primer pair 4

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-24066, MGI:1196333
    References
    more
    • Summaries
      All 76
      Developmental Gene Expression 13
      Gene Ontology 9
      Phenotypes 15
    • Earliest
      J:18478 Gariboldi M, et al., Genetic mapping of the mouse CDC25Mm gene, a ras-specific guanine nucleotide-releasing factor, to chromosome 9. Genomics. 1994 May 15;21(2):451-3
    • Latest
      J:332882 Li N, et al., CFIm-mediated alternative polyadenylation safeguards the development of mammalian pre-implantation embryos. Stem Cell Reports. 2023 Jan 10;18(1):81-96
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory