Cyp2c29 MGI Mouse Gene Detail - MGI:103238 - cytochrome P450, family 2, subfamily c, polypeptide 29

Symbol

Cyp2c29
Name

cytochrome P450, family 2, subfamily c, polypeptide 29
Synonyms

Ah-2, Ahh-1, AHOH, AHOHase, Cyp2c, P450-2C

Feature Type

protein coding gene
IDs

MGI:103238
NCBI Gene: 13095
Alliance

gene page
Transcription Start Sites

31 TSS

Sequence Map

Chr19:39275541-39319157 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 33.91 cM, cytoband D2
Mapping Data

29 experiments

SNPs within 2kb

1098 from dbSNP Build 142
Strain Annotations

17
RFLP

8

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_103238	protein coding gene	Chr19:39257849-39319157 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025100	protein coding gene	Chr19:38391856-38450333 (+)
A/J	MGP_AJ_G0025076	protein coding gene	Chr19:36507012-36563742 (+)
AKR/J	MGP_AKRJ_G0025044	protein coding gene	Chr19:37736625-37805813 (+)
BALB/cJ	MGP_BALBcJ_G0025074	protein coding gene	Chr19:36610621-36675732 (+)
C3H/HeJ	MGP_C3HHeJ_G0024833	protein coding gene	Chr19:37820504-37885541 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025515	protein coding gene	Chr19:39434850-39495486 (+)
CAROLI/EiJ	no annotation
CAST/EiJ	MGP_CASTEiJ_G0024299	protein coding gene	Chr19:37616876-37673615 (+)
CBA/J	MGP_CBAJ_G0024810	protein coding gene	Chr19:41352945-41417437 (+)
DBA/2J	MGP_DBA2J_G0024942	protein coding gene	Chr19:36336876-36410257 (+)
FVB/NJ	MGP_FVBNJ_G0024903	protein coding gene	Chr19:36174051-36235543 (+)
LP/J	MGP_LPJ_G0025028	protein coding gene	Chr19:38452659-38510568 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024934	protein coding gene	Chr19:41052393-41129412 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025573	protein coding gene	Chr19:37827242-37886612 (+)
PWK/PhJ	MGP_PWKPhJ_G0024051	protein coding gene	Chr19:36202657-36260045 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023851	protein coding gene	Chr19:36600553-36660935 (+)
WSB/EiJ	MGP_WSBEiJ_G0024367	protein coding gene	Chr19:37931407-37988679 (+)

Human Ortholog

CYP2C18, cytochrome P450 family 2 subfamily C member 18

Vertebrate Orthologs

7

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CYP2C18, cytochrome P450 family 2 subfamily C member 18
Synonyms

CPCI, CYP2C, CYP2C17, P450-6B/29C, P450IIC17
Links

HGNC:2620

NCBI Gene ID: 1562

neXtProt AC: NX_P33260

UniProt: P33260
Chr Location

10q23.33; chr10:94683729-94736190 (+) GRCh38

Human Ortholog

CYP2C19, cytochrome P450 family 2 subfamily C member 19
Synonyms

CPCJ, CYP2C, CYPIIC17, CYPIIC19, P450C2C, P450IIC19
Links

HGNC:2621

NCBI Gene ID: 1557

neXtProt AC: NX_P33261

UniProt: P33261
Chr Location

10q23.33; chr10:94762681-94855547 (+) GRCh38

Human Ortholog

CYP2C8, cytochrome P450 family 2 subfamily C member 8
Synonyms

CPC8, CYP2C8DM, CYPIIC8, MP-12/MP-20
Links

HGNC:2622

NCBI Gene ID: 1558

neXtProt AC: NX_P10632

UniProt: P10632
Chr Location

10q23.33; chr10:95036772-95069497 (-) GRCh38

Human Ortholog

CYP2C9, cytochrome P450 family 2 subfamily C member 9
Synonyms

CPC9, CYP2C, CYP2C10, CYPIIC9, P450-2C9, P450IIC9
Links

HGNC:2623

NCBI Gene ID: 1559

neXtProt AC: NX_P11712

UniProt: P11712
Chr Location

10q23.33; chr10:94938658-94990091 (+) GRCh38

MGI Vertebrate Homology

Cyp2c29 stringent orthology
4 human;1 mouse;2 rat;1 zebrafish
HCOP

vertebrate homology predictions: CYP2C18, CYP2C19, CYP2C8, CYP2C9
Gene Tree

Cyp2c29

Diseases

21 with human CYP2C19,CYP2C8,CYP2C9 associations

				Human Disease	Mouse Models
				breast cancer IDs breast cancer DOID:1612 DOID:1648 DOID:4241 ICD10CM:C50 ICD9CM:174.8 MESH:D001943 NCI:C9335 OMIM:114480 UMLS_CUI:C0006142
				diabetes mellitus IDs diabetes mellitus DOID:9351 ICD10CM:E08-E13 ICD9CM:250 MESH:D003920 NCI:C2985 UMLS_CUI:C0011849
				end stage renal disease IDs end stage renal disease DOID:783
				eosinophilic esophagitis IDs eosinophilic esophagitis DOID:13922 EFO:0004232 ICD10CM:K20.0 ICD9CM:530.13 MESH:D057765 NCI:C27105 OMIM:610247 OMIM:613412 ORDO:73247 UMLS_CUI:C0341106
				head and neck squamous cell carcinoma IDs head and neck squamous cell carcinoma DOID:5520 MESH:D000077195 NCI:C34447 OMIM:275355 UMLS_CUI:C1168401
				hepatocellular carcinoma IDs hepatocellular carcinoma DOID:684 DOID:5005 EFO:0000182 ICD10CM:C22.0 MESH:D006528 NCI:C3099 OMIM:114550 ORDO:88673 UMLS_CUI:C2239176
				heroin dependence IDs heroin dependence DOID:9976 MESH:D006556 NCI:C34694 UMLS_CUI:C0019337
				hyperglycemia IDs hyperglycemia DOID:4195 ICD10CM:R73.9 MESH:D006943 NCI:C26797 UMLS_CUI:C0020456
				hypertension IDs hypertension DOID:10763 EFO:0000537 ICD10CM:I10 ICD9CM:401-405.99 ICD9CM:997.91 MESH:D006973 NCI:C3117 UMLS_CUI:C0020538
				hypoglycemia IDs hypoglycemia DOID:9993 ICD10CM:E16.2 ICD9CM:251.2 MESH:D007003 NCI:C3126 UMLS_CUI:C0020615
				invasive aspergillosis IDs invasive aspergillosis DOID:0050073
				multiple chemical sensitivity IDs multiple chemical sensitivity DOID:4661 MESH:D018777 UMLS_CUI:C0242992
				multiple myeloma IDs multiple myeloma DOID:9538 EFO:0001378 ICD10CM:C90.0 ICD9CM:203.0 MESH:D009101 NCI:C3242 OMIM:254500 ORDO:29073 UMLS_CUI:C0026764
				peptic ulcer disease IDs peptic ulcer disease DOID:750 DOID:11466 DOID:12635 DOID:13115 ICD10CM:K27 ICD9CM:533 MESH:D010437 NCI:C3318 UMLS_CUI:C0030920
				Plasmodium falciparum malaria IDs Plasmodium falciparum malaria DOID:14067 ICD10CM:B50 ICD9CM:084.0 ICD9CM_2006:084.0 MESH:D016778 NCI:C34798 UMLS_CUI:C0024535
				renal hypertension IDs renal hypertension DOID:1073 MESH:D006977 NCI:C3121 UMLS_CUI:C0020544
				sickle cell anemia IDs sickle cell anemia DOID:10923 DOID:12924 DOID:13024 ICD10CM:D57.1 ICD10CM:D57.2 ICD9CM_2006:282.63 ICD9CM:282.6 ICD9CM:282.60 ICD9CM:282.63 MESH:D000755 MESH:D006450 NCI:C34383 NCI:C34676 ORDO:232 UMLS_CUI:C0002895 UMLS_CUI:C0019034
				tuberculosis IDs tuberculosis DOID:399 DOID:10096 DOID:12688 DOID:12691 DOID:415 DOID:9901 DOID:9902 MESH:D014375 UMLS_CUI:C0041295
				type 2 diabetes mellitus IDs type 2 diabetes mellitus DOID:9352 ICD10CM:E11 KEGG:04930 MESH:D003924 NCI:C26747 OMIM:125853 OMIM:601283 OMIM:601407 OMIM:603694 OMIM:608036 UMLS_CUI:C0011860
				urinary bladder cancer IDs urinary bladder cancer DOID:11054 DOID:5428 ICD10CM:C67 ICD9CM:188 ICD9CM:188.9 KEGG:05219 MESH:D001749 NCI:C2901 NCI:C9334 OMIM:109800 UMLS_CUI:C0005684 UMLS_CUI:C0005695
				warfarin resistance IDs warfarin resistance DOID:0080665 OMIM:122700

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

9 phenotype references

All Mutations and Alleles

6
Endonuclease-mediated

2
Targeted

4
Genomic Mutations

2 involving Cyp2c29
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

34 strains or lines available

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All GO Annotations

40
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

832
Tissues

110
cDNA Data

145
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

GEO

Expression Atlas

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All Sequences

41
RefSeq

4
UniProt

4
CCDS

CCDS29793.1

Ensembl

ENSMUSG00000003053 (Evidence)
NCBI Gene

13095

			Length	Strain/Species	Flank
genomic	13095	NCBI Gene Model \| MGI Sequence Detail	43617	C57BL/6J	± kb
transcript	NM_007815	RefSeq \| MGI Sequence Detail	1774	ZRU/MplStud
polypeptide	Q64458	UniProt \| EBI \| MGI Sequence Detail	490	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000006225 cytochrome P450 2C29

(term hierarchy)
EC

1.14.14.1
InterPro Domains

IPR001128 Cytochrome P450

IPR017972 Cytochrome P450, conserved site

IPR002401 Cytochrome P450, E-class, group I

IPR008068 Cytochrome P450, E-class, group I, CYP2B-like

IPR050182 Cytochrome P450 family 2

IPR036396 Cytochrome P450 superfamily
GlyGen

Q64458 1 site, 1 O-linked glycan (1 site)

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All nucleic 152

cDNA 148

Primer pair 2

Other 2

Microarray probesets 3

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MGD-MRK-1200, MGD-MRK-1220, MGD-MRK-13110, MGD-MRK-2319, MGD-MRK-24113, MGI:2147480, MGI:2147488

Summaries

All 67

Developmental Gene Expression 4

Gene Ontology 9

Phenotypes 9
Earliest

J:84316 Niwa A, et al., Genetic expression of aryl hydrocarbon hydroxylase activity in the mouse. Distinction between the 'responsive' homozygote and heterozygote at the Ah locus. Arch Biochem Biophys. 1975 Feb;166(2):559-64
Latest

J:342868 Oguro A, et al., Maternal DHA intake in mice increased DHA metabolites in the pup brain and ameliorated MeHg-induced behavioral disorder. J Lipid Res. 2023 Nov;64(11):100458

TSS for Cyp2c29:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr156323	Chr19:39275532-39275548 (+)	-1 bp
Tssr156324	Chr19:39279195-39279224 (+)	3,669 bp
Tssr156325	Chr19:39279275-39279291 (+)	3,742 bp
Tssr156326	Chr19:39279535-39279553 (+)	4,003 bp
Tssr156327	Chr19:39279938-39279945 (+)	4,401 bp
Tssr156328	Chr19:39279998-39280003 (+)	4,460 bp
Tssr156329	Chr19:39285104-39285120 (+)	9,571 bp
Tssr156330	Chr19:39288510-39288514 (+)	12,971 bp
Tssr156331	Chr19:39296052-39296068 (+)	20,519 bp
Tssr156332	Chr19:39296138-39296153 (+)	20,605 bp
Tssr156333	Chr19:39298089-39298111 (+)	22,559 bp
Tssr156334	Chr19:39298138-39298143 (+)	22,600 bp
Tssr156335	Chr19:39298220-39298232 (+)	22,685 bp
Tssr156336	Chr19:39299117-39299128 (+)	23,582 bp
Tssr156337	Chr19:39303924-39303932 (+)	28,387 bp
Tssr156338	Chr19:39303958-39303965 (+)	28,421 bp
Tssr156339	Chr19:39303983-39303991 (+)	28,446 bp
Tssr156340	Chr19:39304083-39304115 (+)	28,558 bp
Tssr156341	Chr19:39304132-39304141 (+)	28,596 bp
Tssr156342	Chr19:39307967-39307988 (+)	32,437 bp
Tssr156343	Chr19:39310020-39310050 (+)	34,494 bp
Tssr156344	Chr19:39310066-39310070 (+)	34,527 bp
Tssr156345	Chr19:39313377-39313386 (+)	37,841 bp
Tssr156346	Chr19:39313412-39313423 (+)	37,877 bp
Tssr156347	Chr19:39313449-39313482 (+)	37,925 bp
Tssr156348	Chr19:39317543-39317559 (+)	42,010 bp
Tssr156349	Chr19:39317595-39317630 (+)	42,072 bp
Tssr156350	Chr19:39318701-39318706 (+)	43,163 bp
Tssr156351	Chr19:39318715-39318726 (+)	43,180 bp
Tssr156352	Chr19:39318734-39318750 (+)	43,201 bp
Tssr156353	Chr19:39318831-39318836 (+)	43,293 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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