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Tfap4 Gene Detail
Summary
  • Symbol
    Tfap4
  • Name
    transcription factor AP4
  • Synonyms
    AP-4, bHLHc41, D930048N17Rik, Tcfap4
  • Feature Type
    protein coding gene
  • IDs
    MGI:103239
    NCBI Gene: 83383
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:4362525-4377718 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 2.45 cM, cytoband A1
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    304 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_103239
 protein coding gene Chr16:4362525-4378625 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022464
 protein coding gene Chr16:1030264-1044857 (-)
A/J MGP_AJ_G0022426
 protein coding gene Chr16:872082-886838 (-)
AKR/J MGP_AKRJ_G0022403
 protein coding gene Chr16:1037681-1054518 (-)
BALB/cJ MGP_BALBcJ_G0022431
 protein coding gene Chr16:1023190-1038259 (-)
C3H/HeJ MGP_C3HHeJ_G0022198
 protein coding gene Chr16:1068093-1084695 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022880
 protein coding gene Chr16:1095290-1111617 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020401
 protein coding gene Chr16:814352-828878 (-)
CAST/EiJ MGP_CASTEiJ_G0021724
 protein coding gene Chr16:1055637-1073058 (-)
CBA/J MGP_CBAJ_G0022167
 protein coding gene Chr16:1176553-1191305 (-)
DBA/2J MGP_DBA2J_G0022298
 protein coding gene Chr16:979065-994323 (-)
FVB/NJ MGP_FVBNJ_G0022273
 protein coding gene Chr16:961896-976967 (-)
LP/J MGP_LPJ_G0022366
 protein coding gene Chr16:1034211-1048961 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022295
 protein coding gene Chr16:1044983-1063112 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022892
 protein coding gene Chr16:1016180-1032238 (-)
PWK/PhJ MGP_PWKPhJ_G0021464
 protein coding gene Chr16:1038553-1053668 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021295
 protein coding gene Chr16:1106361-1120566 (-)
WSB/EiJ MGP_WSBEiJ_G0021773
 protein coding gene Chr16:1033532-1049497 (-)



Homology
more
  • Human Ortholog
    TFAP4, transcription factor AP-4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TFAP4, transcription factor AP-4
  • Synonyms
    AP-4, bHLHc41
  • Links
    NCBI Gene ID: 7023
    neXtProt AC: NX_Q01664
    UniProt: Q01664

  • Chr Location
    16p13.3; chr16:4257186-4273075 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit partial prenatal lethality and reduced suppression of Cd4 in double negative thymocytes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    35
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    813
  • Tissues
    72
  • cDNA Data
    26
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000005718 Ensembl Gene Model | MGI Sequence Detail 15194 C57BL/6J ±  kb
    transcript ENSMUST00000005862 Ensembl | MGI Sequence Detail 2247 Not Applicable  
    polypeptide ENSMUSP00000005862 Ensembl | MGI Sequence Detail 338 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • InterPro Domains
      IPR036638 Helix-loop-helix DNA-binding domain superfamily
      IPR052207 Max-like/E-box-binding transcription factors
      IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
    • GlyGen
      Q9JIZ5 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 29
      cDNA 28
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-24114, MGI:1932513, MGI:2146466
    References
    more
    • Summaries
      All 61
      Developmental Gene Expression 11
      Gene Ontology 3
      Phenotypes 18
    • Earliest
      J:30071 Mermod N, et al., Enhancer binding factors AP-4 and AP-1 act in concert to activate SV40 late transcription in vitro. Nature. 1988 Apr 7;332(6164):557-61
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory