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Cebpe Gene Detail
Summary
  • Symbol
    Cebpe
  • Name
    CCAAT/enhancer binding protein epsilon
  • Synonyms
    C/EBPe, C/EBPepsilon, CRP1, LOC239097
  • Feature Type
    protein coding gene
  • IDs
    MGI:103572
    NCBI Gene: 110794
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:54947823-54949604 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 27.90 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    130 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_103572
 protein coding gene Chr14:54947817-54949631 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021323
 protein coding gene Chr14:48681114-48682922 (-)
A/J MGP_AJ_G0021282
 protein coding gene Chr14:47722393-47724201 (-)
AKR/J MGP_AKRJ_G0021258
 protein coding gene Chr14:49446604-49448412 (-)
BALB/cJ MGP_BALBcJ_G0021286
 protein coding gene Chr14:47697357-47699165 (-)
C3H/HeJ MGP_C3HHeJ_G0021066
 protein coding gene Chr14:49145751-49147559 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021724
 protein coding gene Chr14:51142504-51144315 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019269
 protein coding gene Chr14:46136984-46138797 (-)
CAST/EiJ MGP_CASTEiJ_G0020585
 protein coding gene Chr14:45386709-45388517 (-)
CBA/J MGP_CBAJ_G0021033
 protein coding gene Chr14:52681349-52683157 (-)
DBA/2J MGP_DBA2J_G0021154
 protein coding gene Chr14:47461602-47463410 (-)
FVB/NJ MGP_FVBNJ_G0021136
 protein coding gene Chr14:46916194-46918002 (-)
LP/J MGP_LPJ_G0021228
 protein coding gene Chr14:49679833-49681641 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021160
 protein coding gene Chr14:52075575-52077383 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021751
 protein coding gene Chr14:48636612-48638420 (-)
PWK/PhJ MGP_PWKPhJ_G0020331
 protein coding gene Chr14:43995509-43997317 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020159
 protein coding gene Chr14:44618450-44620223 (-)
WSB/EiJ MGP_WSBEiJ_G0020638
 protein coding gene Chr14:48922344-48924152 (-)



Homology
more
  • Human Ortholog
    CEBPE, CCAAT enhancer binding protein epsilon
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CEBPE, CCAAT enhancer binding protein epsilon
  • Synonyms
    c/EBP epsilon, C/EBP-epsilon, CRP1, IMD108, SGD1
  • Links
    NCBI Gene ID: 1053
    neXtProt AC: NX_Q15744
    UniProt: Q15744

  • Chr Location
    14q11.2; chr14:23117036-23120256 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human CEBPE associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    27 phenotypes from 1 allele in 2 genetic backgrounds
    1 images
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in impaired neutrophil and eosinophil development and myelodysplasia. Mutant animals are susceptible to secondary bacterial infections such as conjuntivitis, rhinitis, and pneumonia, and become moribund between 2-5 months of age.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    727
  • Tissues
    12
  • cDNA Data
    10
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 110794 NCBI Gene Model | MGI Sequence Detail 1782 C57BL/6J ±  kb
    transcript NM_207131 RefSeq | MGI Sequence Detail 1208 ZRU/MplStud  
    polypeptide Q6PZD9 UniProt | EBI | MGI Sequence Detail 281 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      Genomic 3
      cDNA 11
      Primer pair 1
      Other 1

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGD-MRK-24457, MGI:2685140
    References
    more
    • Summaries
      All 61
      Developmental Gene Expression 4
      Gene Ontology 9
      Phenotypes 26
    • Earliest
      J:28024 Jenkins NA, et al., Mouse chromosomal location of the CCAAT/enhancer binding proteins C/EBP beta (Cebpb), C/EBP delta (Cebpd), and CRP1 (Cebpe). Genomics. 1995 Jul 20;28(2):333-6
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory