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Cdkn1b Gene Detail
Summary
  • Symbol
    Cdkn1b
  • Name
    cyclin dependent kinase inhibitor 1B
  • Synonyms
    p27, p27Kip1
  • Feature Type
    protein coding gene
  • IDs
    MGI:104565
    NCBI Gene: 12576
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:134897364-134902476 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 65.77 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    132 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104565
 protein coding gene Chr6:134897364-134902488 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031410
 protein coding gene Chr6:139221070-139226987 (+)
A/J MGP_AJ_G0031386
 protein coding gene Chr6:133755945-133761070 (+)
AKR/J MGP_AKRJ_G0031313
 protein coding gene Chr6:137813753-137819614 (+)
BALB/cJ MGP_BALBcJ_G0031392
 protein coding gene Chr6:133570239-133575499 (+)
C3H/HeJ MGP_C3HHeJ_G0031114
 protein coding gene Chr6:137857797-137864635 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031852
 protein coding gene Chr6:142998422-143005389 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028984
 protein coding gene Chr6:132899345-132904493 (+)
CAST/EiJ MGP_CASTEiJ_G0030483
 protein coding gene Chr6:137272073-137278914 (+)
CBA/J MGP_CBAJ_G0031073
 protein coding gene Chr6:148339976-148345108 (+)
DBA/2J MGP_DBA2J_G0031231
 protein coding gene Chr6:132606613-132611936 (+)
FVB/NJ MGP_FVBNJ_G0031181
 protein coding gene Chr6:131520071-131525184 (+)
LP/J MGP_LPJ_G0031315
 protein coding gene Chr6:139325986-139330983 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031221
 protein coding gene Chr6:152363596-152381583 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031885
 protein coding gene Chr6:137551415-137558375 (+)
PWK/PhJ MGP_PWKPhJ_G0030208
 protein coding gene Chr6:131097316-131103040 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030032
 protein coding gene Chr6:135725563-135730660 (+)
WSB/EiJ MGP_WSBEiJ_G0030574
 protein coding gene Chr6:138183064-138190218 (+)



Homology
more
  • Human Ortholog
    CDKN1B, cyclin dependent kinase inhibitor 1B
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CDKN1B, cyclin dependent kinase inhibitor 1B
  • Synonyms
    CDKN4, KIP1, MEN1B, MEN4, P27KIP1
  • Links
    NCBI Gene ID: 1027
    neXtProt AC: NX_P46527
    UniProt: P46527

  • Chr Location
    12p13.1; chr12:12685498-12722369 (+)  GRCh38
Human Diseases
more
  • Diseases
    4 with human CDKN1B associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    93 phenotypes from 9 alleles in 9 genetic backgrounds
    127 phenotypes from multigenic genotypes
    291 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutants have increased body weight, enlargement of major organs, impaired hearing and increased tumor susceptibility. Females are sterile, having impaired luteal cell differentiation and disrupted estrus cycle.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    120
  • GO References
    31
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1267
  • Tissues
    239
  • cDNA Data
    42
  • Literature Summary
    428
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000003031 Ensembl Gene Model | MGI Sequence Detail 5113 C57BL/6J ±  kb
    transcript ENSMUST00000067327 Ensembl | MGI Sequence Detail 4552 Not Applicable  
    polypeptide ENSMUSP00000065832 Ensembl | MGI Sequence Detail 197 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000003090 cyclin-dependent kinase inhibitor 1B
      (term hierarchy)
    • InterPro Domains
      IPR003175 Cyclin-dependent kinase inhibitor domain
      IPR044898 Cyclin-dependent kinase inhibitor domain superfamily
    • GlyGen
      P46414 1 site, 1 N-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 68
      Genomic 1
      cDNA 45
      Primer pair 21
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-25999, MGI:2141358, MGI:2141489
    References
    more
    • Summaries
      All 853
      Developmental Gene Expression 428
      Diseases 2
      Gene Ontology 31
      Phenotypes 291
    • Earliest
      J:19217 Polyak K, et al., Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals. Cell. 1994 Jul 15;78(1):59-66
    • Latest
      J:354051 Kagoshima H, et al., EBF1 Limits the Numbers of Cochlear Hair and Supporting Cells and Forms the Scala Tympani and Spiral Limbus during Inner Ear Development. J Neurosci. 2024 Feb 14;44(7)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory