About   Help   FAQ
Limk1 Gene Detail
Summary
  • Symbol
    Limk1
  • Name
    LIM domain kinase 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:104572
    NCBI Gene: 16885
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:134684893-134717452 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 74.73 cM, cytoband G2
  • Mapping Data
    19 experiments
Strain
Comparison
more
  • SNPs within 2kb
    976 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104572
 protein coding gene Chr5:134684893-134718713 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030162
 protein coding gene Chr5:139089133-139123062 (-)
A/J MGP_AJ_G0030130
 protein coding gene Chr5:133177196-133210659 (-)
AKR/J MGP_AKRJ_G0030063
 protein coding gene Chr5:137495003-137527267 (-)
BALB/cJ MGP_BALBcJ_G0030140
 protein coding gene Chr5:134531957-134564520 (-)
C3H/HeJ MGP_C3HHeJ_G0029856
 protein coding gene Chr5:138048269-138082034 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030593
 protein coding gene Chr5:144321835-144360312 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027817
 protein coding gene Chr5:127464178-127496364 (-)
CAST/EiJ MGP_CASTEiJ_G0029265
 protein coding gene Chr5:137475470-137509063 (-)
CBA/J MGP_CBAJ_G0029826
 protein coding gene Chr5:149955145-149990681 (-)
DBA/2J MGP_DBA2J_G0029977
 protein coding gene Chr5:133070975-133103878 (-)
FVB/NJ MGP_FVBNJ_G0029932
 protein coding gene Chr5:132203046-132235655 (-)
LP/J MGP_LPJ_G0030065
 protein coding gene Chr5:139561270-139595137 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029964
 protein coding gene Chr5:153001425-153035201 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030633
 protein coding gene Chr5:137227258-137260330 (-)
PWK/PhJ MGP_PWKPhJ_G0028980
 protein coding gene Chr5:132106991-132142048 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028815
 protein coding gene Chr5:134805633-134839731 (-)
WSB/EiJ MGP_WSBEiJ_G0029339
 protein coding gene Chr5:137977240-138015158 (-)



Homology
more
  • Human Ortholog
    LIMK1, LIM domain kinase 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LIMK1, LIM domain kinase 1
  • Synonyms
    LIMK, LIMK-1
  • Links
    NCBI Gene ID: 3984
    neXtProt AC: NX_P53667
    UniProt: P53667

  • Chr Location
    7q11.23; chr7:74082933-74122525 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Limk1 mouse models

Human Disease Mouse Models
      
IDs
 View 3 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display an abnormal actin cytoskeleton in neurons of the central nervous system and structural abnormalities of the dendritic spines. Long term potentiation is altered and behavioral anomalies are seen.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    68
  • GO References
    17
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1010
  • Tissues
    223
  • cDNA Data
    57
  • Literature Summary
    39
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000029674 Ensembl Gene Model | MGI Sequence Detail 32560 C57BL/6J ±  kb
    transcript ENSMUST00000015137 Ensembl | MGI Sequence Detail 3331 Not Applicable  
    polypeptide ENSMUSP00000015137 Ensembl | MGI Sequence Detail 647 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 75
      Genomic 10
      cDNA 57
      Primer pair 7
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-26006
    References
    more
    • Summaries
      All 130
      Developmental Gene Expression 39
      Diseases 3
      Gene Ontology 17
      Phenotypes 30
    • Earliest
      J:37753 Bernard O, et al., Kiz-1, a protein with LIM zinc finger and kinase domains, is expressed mainly in neurons. Cell Growth Differ. 1994 Nov;5(11):1159-71
    • Latest
      J:337436 Abdalla N, et al., Dysfunctional Mitochondria in the Cardiac Fibers of a Williams-Beuren Syndrome Mouse Model. Int J Mol Sci. 2023 Jun 13;24(12)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory