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Cnr1 Gene Detail
Summary
  • Symbol
    Cnr1
  • Name
    cannabinoid receptor 1
  • Synonyms
    CB1, CB1R
  • Feature Type
    protein coding gene
  • IDs
    MGI:104615
    NCBI Gene: 12801
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:33924593-33948831 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 16.28 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    481 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104615
 protein coding gene Chr4:33923171-33948831 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028124
 protein coding gene Chr4:31479235-31503473 (+)
A/J MGP_AJ_G0028082
 protein coding gene Chr4:30360546-30384735 (+)
AKR/J MGP_AKRJ_G0028045
 protein coding gene Chr4:31161707-31185896 (+)
BALB/cJ MGP_BALBcJ_G0028093
 protein coding gene Chr4:30618634-30643242 (+)
C3H/HeJ MGP_C3HHeJ_G0027822
 protein coding gene Chr4:31464396-31488840 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028535
 protein coding gene Chr4:32702638-32726825 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025876
 protein coding gene Chr4:28503512-28527716 (+)
CAST/EiJ MGP_CASTEiJ_G0027277
 protein coding gene Chr4:31235188-31260871 (+)
CBA/J MGP_CBAJ_G0027794
 protein coding gene Chr4:33776375-33800583 (+)
DBA/2J MGP_DBA2J_G0027938
 protein coding gene Chr4:30347888-30372296 (+)
FVB/NJ MGP_FVBNJ_G0027904
 protein coding gene Chr4:29785658-29809864 (+)
LP/J MGP_LPJ_G0028046
 protein coding gene Chr4:31575686-31599766 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027937
 protein coding gene Chr4:36367193-36391722 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028594
 protein coding gene Chr4:31170723-31194950 (+)
PWK/PhJ MGP_PWKPhJ_G0026996
 protein coding gene Chr4:30366034-30390763 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026825
 protein coding gene Chr4:31050264-31074457 (+)
WSB/EiJ MGP_WSBEiJ_G0027353
 protein coding gene Chr4:31175735-31200998 (+)



Homology
more
  • Human Ortholog
    CNR1, cannabinoid receptor 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CNR1, cannabinoid receptor 1
  • Synonyms
    CANN6, CB1, CB1A, CB1K5, CB1R, CB-R, CNR
  • Links
    NCBI Gene ID: 1268
    neXtProt AC: NX_P21554
    UniProt: P21554

  • Chr Location
    6q15; chr6:88139864-88167349 (-)  GRCh38
Human Diseases
more
  • Diseases
    3 with human CNR1 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    85 phenotypes from 12 alleles in 20 genetic backgrounds
    8 phenotypes from multigenic genotypes
    441 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit abnormal behaviors, altered long term depression and susceptibility to induced seizure.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    89
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    991
  • Tissues
    185
  • cDNA Data
    20
  • Literature Summary
    41
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000044288 Ensembl Gene Model | MGI Sequence Detail 24239 C57BL/6J ±  kb
    transcript ENSMUST00000057188 Ensembl | MGI Sequence Detail 5807 Not Applicable  
    polypeptide ENSMUSP00000055797 Ensembl | MGI Sequence Detail 473 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 32
      Genomic 6
      cDNA 20
      Primer pair 2
      Other 4

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-26052
    References
    more
    • Summaries
      All 607
      Developmental Gene Expression 41
      Diseases 1
      Gene Ontology 11
      Phenotypes 441
    • Earliest
      J:29411 Paria BC, et al., The preimplantation mouse embryo is a target for cannabinoid ligand-receptor signaling. Proc Natl Acad Sci U S A. 1995 Oct 10;92(21):9460-4
    • Latest
      J:358230 Guo B, et al., CB1R dysfunction of inhibitory synapses in the ACC drives chronic social isolation stress-induced social impairments in male mice. Neuron. 2024 Feb 7;112(3):441-457.e6
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory