About   Help   FAQ
Ccr1 Gene Detail
Summary
  • Symbol
    Ccr1
  • Name
    C-C motif chemokine receptor 1
  • Synonyms
    Cmkbr1
  • Feature Type
    protein coding gene
  • IDs
    MGI:104618
    NCBI Gene: 12768
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:123762163-123768729 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 75.05 cM, cytoband F
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    151 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104618
 protein coding gene Chr9:123762161-123768729 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035489
 protein coding gene Chr9:127072791-127075231 (-)
A/J MGP_AJ_G0035467
 protein coding gene Chr9:122172972-122179655 (-)
AKR/J MGP_AKRJ_G0035400
 protein coding gene Chr9:125444979-125450177 (-)
BALB/cJ MGP_BALBcJ_G0035463
 protein coding gene Chr9:122097195-122103761 (-)
C3H/HeJ MGP_C3HHeJ_G0035170
 protein coding gene Chr9:125891302-125897972 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035986
 protein coding gene Chr9:130533694-130540349 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032868
 protein coding gene Chr9:119229851-119236401 (-)
CAST/EiJ MGP_CASTEiJ_G0034475
 protein coding gene Chr9:125893513-125898852 (-)
CBA/J MGP_CBAJ_G0035138
 protein coding gene Chr9:135329673-135336651 (-)
DBA/2J MGP_DBA2J_G0035297
 protein coding gene Chr9:121653675-121661221 (-)
FVB/NJ MGP_FVBNJ_G0035244
 protein coding gene Chr9:120514497-120521254 (-)
LP/J MGP_LPJ_G0035376
 protein coding gene Chr9:127431651-127439101 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035285
 protein coding gene Chr9:136107610-136128459 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036005
 protein coding gene Chr9:125911547-125917562 (-)
PWK/PhJ MGP_PWKPhJ_G0034179
 protein coding gene Chr9:122038776-122066501 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034016
 protein coding gene Chr9:125958064-125979724 (-)
WSB/EiJ MGP_WSBEiJ_G0034595
 protein coding gene Chr9:125700090-125714319 (-)



Homology
more
  • Human Ortholog
    CCR1, C-C motif chemokine receptor 1
  • Vertebrate Orthologs
    8
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CCR1, C-C motif chemokine receptor 1
  • Synonyms
    CD191, CKR-1, CKR1, CMKBR1, HM145, MIP1aR, SCYAR1
  • Links
    NCBI Gene ID: 1230
    neXtProt AC: NX_P32246
    UniProt: P32246

  • Chr Location
    3p21.31; chr3:46201711-46208313 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Ccr1 mouse models; 2 with human CCR1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    45 phenotypes from 2 alleles in 6 genetic backgrounds
    2 phenotypes from multigenic genotypes
    2 images
    83 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit altered trafficking and proliferation of myeloid progenitor cells, and impairments in granulomatous inflammation of the lung and neutrophil associated host defense.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    48
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    716
  • Tissues
    10
  • cDNA Data
    17
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12768 NCBI Gene Model | MGI Sequence Detail 6567 C57BL/6J ±  kb
    transcript NM_009912 RefSeq | MGI Sequence Detail 2831 ZRU/MplStud  
    polypeptide P51675 UniProt | EBI | MGI Sequence Detail 355 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 22
      Genomic 2
      cDNA 17
      Primer pair 1
      Other 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-26055
    References
    more
    • Summaries
      All 133
      Developmental Gene Expression 5
      Diseases 1
      Gene Ontology 10
      Phenotypes 83
    • Earliest
      J:27219 Gao JL, et al., Cloning and differential tissue-specific expression of three mouse beta chemokine receptor-like genes, including the gene for a functional macrophage inflammatory protein-1 alpha receptor. J Biol Chem. 1995 Jul 21;270(29):17494-501
    • Latest
      J:333829 Lopez-Tello J, et al., Characterization of placental endocrine function and fetal brain development in a mouse model of small for gestational age. Front Endocrinol (Lausanne). 2023;14:1116770
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory