About   Help   FAQ
Penk Gene Detail
Summary
  • Symbol
    Penk
  • Name
    preproenkephalin
  • Synonyms
    ENK, Penk, Penk1, PPA
  • Feature Type
    protein coding gene
  • IDs
    MGI:104629
    NCBI Gene: 18619
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:4133536-4138815 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 2.31 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    191 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104629
 protein coding gene Chr4:4133531-4138819 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028030
 protein coding gene Chr4:613693-620591 (-)
A/J MGP_AJ_G0027988
 protein coding gene Chr4:696000-701287 (-)
AKR/J MGP_AKRJ_G0027954
 protein coding gene Chr4:637728-643016 (-)
BALB/cJ MGP_BALBcJ_G0028000
 protein coding gene Chr4:653785-659073 (-)
C3H/HeJ MGP_C3HHeJ_G0027730
 protein coding gene Chr4:803769-809081 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028443
 protein coding gene Chr4:799384-804688 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025787
 protein coding gene Chr4:619873-625037 (-)
CAST/EiJ MGP_CASTEiJ_G0027183
 protein coding gene Chr4:698661-703976 (-)
CBA/J MGP_CBAJ_G0027705
 protein coding gene Chr4:679160-684441 (-)
DBA/2J MGP_DBA2J_G0027845
 protein coding gene Chr4:669432-674676 (-)
FVB/NJ MGP_FVBNJ_G0027812
 protein coding gene Chr4:588302-593588 (-)
LP/J MGP_LPJ_G0027956
 protein coding gene Chr4:668852-674797 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027845
 protein coding gene Chr4:862433-868979 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028502
 protein coding gene Chr4:628532-633820 (-)
PWK/PhJ MGP_PWKPhJ_G0026905
 protein coding gene Chr4:732112-737406 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026735
 protein coding gene Chr4:659079-664699 (-)
WSB/EiJ MGP_WSBEiJ_G0027263
 protein coding gene Chr4:775588-780825 (-)



Homology
more
  • Human Ortholog
    PENK, proenkephalin
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PENK, proenkephalin
  • Synonyms
    PE, PENK-A
  • Links
    NCBI Gene ID: 5179
    neXtProt AC: NX_P01210
    UniProt: P01210

  • Chr Location
    8q12.1; chr8:56436674-56446671 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human PENK associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 4 alleles in 4 genetic backgrounds
    46 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit nitrituria. Female homozygotes display decreased circulating triglyceride levels.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    61
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1457
  • Tissues
    305
  • cDNA Data
    73
  • Literature Summary
    82
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18619 NCBI Gene Model | MGI Sequence Detail 5280 C57BL/6J ±  kb
    transcript NM_001348209 RefSeq | MGI Sequence Detail 1267 C57BL/6  
    polypeptide P22005 UniProt | EBI | MGI Sequence Detail 268 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 102
      Genomic 2
      cDNA 83
      Primer pair 9
      Other 8

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-26066, MGI:1889826, MGI:2140244
    References
    more
    • Summaries
      All 185
      Developmental Gene Expression 82
      Gene Ontology 9
      Phenotypes 46
    • Earliest
      J:322698 Inturrisi CE, et al., Analgesic activity of the naturally occurring heptapeptide [Met]enkephalin-Arg6-Phe7. Proc Natl Acad Sci U S A. 1980 Sep;77(9):5512-4
    • Latest
      J:346538 Puri C, et al., Pre-proenkephalin 1 is Downregulated Under Unloading and is Involved in Osteoblast Biology. Calcif Tissue Int. 2024 Mar 20;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory