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Tle4 Gene Detail
Summary
  • Symbol
    Tle4
  • Name
    transducin-like enhancer of split 4
  • Synonyms
    5730411M05Rik, Bce1, ESTM13, ESTM14, Grg4
  • Feature Type
    protein coding gene
  • IDs
    MGI:104633
    NCBI Gene: 21888
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:14425514-14575415 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 9.11 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3632 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104633
 protein coding gene Chr19:14425434-14575542 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024955
 protein coding gene Chr19:12077032-12236732 (-)
A/J MGP_AJ_G0024932
 protein coding gene Chr19:11343297-11496322 (-)
AKR/J MGP_AKRJ_G0024901
 protein coding gene Chr19:11878747-12031843 (-)
BALB/cJ MGP_BALBcJ_G0024930
 protein coding gene Chr19:11389853-11539117 (-)
C3H/HeJ MGP_C3HHeJ_G0024689
 protein coding gene Chr19:11803261-11959411 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025373
 protein coding gene Chr19:12628429-12793691 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022792
 protein coding gene Chr19:11871071-12014167 (-)
CAST/EiJ MGP_CASTEiJ_G0024157
 protein coding gene Chr19:11357045-11506113 (-)
CBA/J MGP_CBAJ_G0024667
 protein coding gene Chr19:12965434-13129985 (-)
DBA/2J MGP_DBA2J_G0024799
 protein coding gene Chr19:11409809-11562599 (-)
FVB/NJ MGP_FVBNJ_G0024760
 protein coding gene Chr19:11362685-11513081 (-)
LP/J MGP_LPJ_G0024882
 protein coding gene Chr19:12092008-12251035 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024786
 protein coding gene Chr19:12885121-13058679 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025428
 protein coding gene Chr19:11755908-11915079 (-)
PWK/PhJ MGP_PWKPhJ_G0023906
 protein coding gene Chr19:10915744-11078988 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023711
 protein coding gene Chr19:11021617-11180109 (-)
WSB/EiJ MGP_WSBEiJ_G0024225
 protein coding gene Chr19:11778218-11932638 (-)



Homology
more
  • Human Ortholog
    TLE4, TLE family member 4, transcriptional corepressor
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TLE4, TLE family member 4, transcriptional corepressor
  • Synonyms
    BCE-1, BCE1, ESG, ESG4, E(spI), E(spl), Grg-4, GRG4
  • Links
    NCBI Gene ID: 7091
    neXtProt AC: NX_Q04727
    UniProt: Q04727

  • Chr Location
    9q21.31; chr9:79571773-79726882 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    49 phenotypes from 2 alleles in 2 genetic backgrounds
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are runted and die around 4 weeks of age with leukocytopenia, B cell lymphopenia, reduced bone mineralization and reduced hematopoietic stem cell number and function.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    32
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1203
  • Tissues
    240
  • cDNA Data
    90
  • Literature Summary
    97
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024642 Ensembl Gene Model | MGI Sequence Detail 149902 C57BL/6J ±  kb
    transcript ENSMUST00000052011 Ensembl | MGI Sequence Detail 4545 Not Applicable  
    polypeptide ENSMUSP00000057527 Ensembl | MGI Sequence Detail 773 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000016375 transducin-like enhancer protein 4
      (term hierarchy)
    • InterPro Domains
      IPR005617 Groucho/TLE, N-terminal Q-rich domain
      IPR009146 Groucho/transducin-like enhancer
      IPR001680 WD40 repeat
      IPR019775 WD40 repeat, conserved site
      IPR036322 WD40-repeat-containing domain superfamily
      IPR015943 WD40/YVTN repeat-like-containing domain superfamily
    • GlyGen
      Q62441 8 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (6 sites)
    Molecular
    Reagents
    less
    • All nucleic 96
      cDNA 91
      Primer pair 2
      Other 3

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-26070, MGD-MRK-28129, MGD-MRK-28130, MGI:104835, MGI:104836, MGI:1917740, MGI:1930703, MGI:2147460
    References
    more
    • Summaries
      All 155
      Developmental Gene Expression 97
      Gene Ontology 11
      Phenotypes 22
    • Earliest
      J:28401 Bettenhausen B, et al., Efficient isolation of novel mouse genes differentially expressed in early postimplantation embryos. Genomics. 1995 Aug 10;28(3):436-41
    • Latest
      J:354227 Barao S, et al., Conserved transcriptional regulation by BRN1 and BRN2 in neocortical progenitors drives mammalian neural specification and neocortical expansion. Nat Commun. 2024 Sep 14;15(1):8043
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory