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Tgfbr3 Gene Detail
Summary
  • Symbol
    Tgfbr3
  • Name
    transforming growth factor, beta receptor III
  • Synonyms
    1110036H20Rik, betaglycan, TBRIII
  • Feature Type
    protein coding gene
  • IDs
    MGI:104637
    NCBI Gene: 21814
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:107254436-107437495 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 51.90 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4347 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104637
 protein coding gene Chr5:107254433-107437495 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029834
 protein coding gene Chr5:109105643-109306936 (-)
A/J MGP_AJ_G0029798
 protein coding gene Chr5:104931388-105122054 (-)
AKR/J MGP_AKRJ_G0029743
 protein coding gene Chr5:108331399-108515026 (-)
BALB/cJ MGP_BALBcJ_G0029810
 protein coding gene Chr5:106078262-106259837 (-)
C3H/HeJ MGP_C3HHeJ_G0029532
 protein coding gene Chr5:108778062-108961285 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030264
 protein coding gene Chr5:113605304-113802133 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027498
 protein coding gene Chr5:100007353-100187394 (-)
CAST/EiJ MGP_CASTEiJ_G0028946
 protein coding gene Chr5:107701069-107900963 (-)
CBA/J MGP_CBAJ_G0029500
 protein coding gene Chr5:117405334-117613909 (-)
DBA/2J MGP_DBA2J_G0029646
 protein coding gene Chr5:105071553-105260211 (-)
FVB/NJ MGP_FVBNJ_G0029603
 protein coding gene Chr5:103807687-103992808 (-)
LP/J MGP_LPJ_G0029734
 protein coding gene Chr5:109704740-109902429 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029635
 protein coding gene Chr5:122351630-122550970 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030298
 protein coding gene Chr5:107886447-108081215 (-)
PWK/PhJ MGP_PWKPhJ_G0028659
 protein coding gene Chr5:103867300-104053060 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028497
 protein coding gene Chr5:105385153-105587135 (-)
WSB/EiJ MGP_WSBEiJ_G0029019
 protein coding gene Chr5:108184356-108379071 (-)



Homology
more
  • Human Ortholog
    TGFBR3, transforming growth factor beta receptor 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TGFBR3, transforming growth factor beta receptor 3
  • Synonyms
    betaglycan, BGCAN
  • Links
    NCBI Gene ID: 7049
    neXtProt AC: NX_Q03167
    UniProt: Q03167

  • Chr Location
    1p22.1; chr1:91680343-91906335 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    42 phenotypes from 3 alleles in 4 genetic backgrounds
    3 phenotypes from multigenic genotypes
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene usually die as embryos. The very few individuals that survive are poorly fertile with abnormalities of the spleen, liver, heart, and skeletal system.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    109
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1197
  • Tissues
    151
  • cDNA Data
    67
  • Literature Summary
    32
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000029287 Ensembl Gene Model | MGI Sequence Detail 183060 C57BL/6J ±  kb
    transcript ENSMUST00000031224 Ensembl | MGI Sequence Detail 6087 Not Applicable  
    polypeptide ENSMUSP00000031224 Ensembl | MGI Sequence Detail 850 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 80
      Genomic 2
      cDNA 67
      Primer pair 11

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-26074, MGI:1921003, MGI:2141029, MGI:2141178
    References
    more
    • Summaries
      All 99
      Developmental Gene Expression 32
      Gene Ontology 15
      Phenotypes 28
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:353622 Dinesh NEH, et al., Fibronectin Isoforms Promote Postnatal Skeletal Development. Matrix Biol. 2024 Aug 17;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory