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Ptpn12 Gene Detail
Summary
  • Symbol
    Ptpn12
  • Name
    protein tyrosine phosphatase, non-receptor type 12
  • Synonyms
    P19-PTP, PTP-P19, PTP-PEST
  • Feature Type
    protein coding gene
  • IDs
    MGI:104673
    NCBI Gene: 19248
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:21191643-21260909 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 9.83 cM, cytoband A3-B
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1820 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104673
 protein coding gene Chr5:21191643-21261009 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029313
 protein coding gene Chr5:18517593-18594886 (-)
A/J MGP_AJ_G0029278
 protein coding gene Chr5:17928585-17998784 (-)
AKR/J MGP_AKRJ_G0029229
 protein coding gene Chr5:18604487-18678334 (-)
BALB/cJ MGP_BALBcJ_G0029290
 protein coding gene Chr5:18355997-18428351 (-)
C3H/HeJ MGP_C3HHeJ_G0029009
 protein coding gene Chr5:18671970-18743125 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029743
 protein coding gene Chr5:19884257-19966462 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026982
 protein coding gene Chr5:16004787-16077145 (-)
CAST/EiJ MGP_CASTEiJ_G0028421
 protein coding gene Chr5:18000801-18078431 (-)
CBA/J MGP_CBAJ_G0028976
 protein coding gene Chr5:20111339-20191992 (-)
DBA/2J MGP_DBA2J_G0029128
 protein coding gene Chr5:18207629-18280778 (-)
FVB/NJ MGP_FVBNJ_G0029086
 protein coding gene Chr5:17619488-17689769 (-)
LP/J MGP_LPJ_G0029212
 protein coding gene Chr5:18930133-19005675 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029114
 protein coding gene Chr5:21424997-21502574 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029776
 protein coding gene Chr5:18274808-18347625 (-)
PWK/PhJ MGP_PWKPhJ_G0028144
 protein coding gene Chr5:17270958-17339387 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027977
 protein coding gene Chr5:17632724-17705568 (-)
WSB/EiJ MGP_WSBEiJ_G0028501
 protein coding gene Chr5:18325113-18395500 (-)



Homology
more
  • Human Ortholog
    PTPN12, protein tyrosine phosphatase non-receptor type 12
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PTPN12, protein tyrosine phosphatase non-receptor type 12
  • Synonyms
    PTPG1, PTP-PEST
  • Links
    NCBI Gene ID: 5782
    neXtProt AC: NX_Q05209
    UniProt: Q05209

  • Chr Location
    7q11.23; chr7:77537295-77640069 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human PTPN12 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    23 phenotypes from 3 alleles in 4 genetic backgrounds
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in early embryonic lethality, defective embryo turning, improper somitogenesis and vasculogenesis, impaired liver development, truncation of the caudal region and mesenchyme deficiency.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    33
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    789
  • Tissues
    53
  • cDNA Data
    82
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028771 Ensembl Gene Model | MGI Sequence Detail 69267 C57BL/6J ±  kb
    transcript ENSMUST00000030556 Ensembl | MGI Sequence Detail 3280 Not Applicable  
    polypeptide ENSMUSP00000030556 Ensembl | MGI Sequence Detail 775 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000013450 tyrosine-protein phosphatase non-receptor type 12
      (term hierarchy)
    • EC
      3.1.3.48
    • InterPro Domains
      IPR016130 Protein-tyrosine phosphatase, active site
      IPR003595 Protein-tyrosine phosphatase, catalytic
      IPR029021 Protein-tyrosine phosphatase-like
      IPR047251 Protein-tyrosine phosphatase non-receptor type-12, catalytic domain
      IPR012266 Tyrosine-protein phosphatase non-receptor type 12
      IPR047170 Tyrosine-protein phosphatase non-receptor type 12/18/22
      IPR000242 Tyrosine-specific protein phosphatase, PTPase domain
      IPR000387 Tyrosine-specific protein phosphatases domain
    • GlyGen
      P35831 4 sites, 3 N-linked glycans (3 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 97
      Genomic 8
      cDNA 84
      Primer pair 3
      Other 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-27036
    References
    more
    • Summaries
      All 81
      Developmental Gene Expression 8
      Diseases 1
      Gene Ontology 16
      Phenotypes 30
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory