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Ncan Gene Detail
Summary
  • Symbol
    Ncan
  • Name
    neurocan
  • Synonyms
    Cspg3, Cspg3-rs, Tgfbit
  • Feature Type
    protein coding gene
  • IDs
    MGI:104694
    NCBI Gene: 13004
  • Alliance
    gene page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:70545735-70573494 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 34.15 cM
  • Mapping Data
    11 experiments
Strain
Comparison
more
  • SNPs within 2kb
    640 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104694
 protein coding gene Chr8:70545735-70573523 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033689
 protein coding gene Chr8:70341837-70369272 (-)
A/J MGP_AJ_G0033672
 protein coding gene Chr8:67479443-67507475 (-)
AKR/J MGP_AKRJ_G0033597
 protein coding gene Chr8:69399893-69427644 (-)
BALB/cJ MGP_BALBcJ_G0033668
 protein coding gene Chr8:67709727-67737178 (-)
C3H/HeJ MGP_C3HHeJ_G0033378
 protein coding gene Chr8:70045459-70072888 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034185
 protein coding gene Chr8:72998375-73027711 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031129
 protein coding gene Chr8:62299025-62327268 (-)
CAST/EiJ MGP_CASTEiJ_G0032703
 protein coding gene Chr8:69527517-69558495 (-)
CBA/J MGP_CBAJ_G0033356
 protein coding gene Chr8:75641710-75675438 (-)
DBA/2J MGP_DBA2J_G0033510
 protein coding gene Chr8:67206400-67234193 (-)
FVB/NJ MGP_FVBNJ_G0033451
 protein coding gene Chr8:66304831-66335573 (-)
LP/J MGP_LPJ_G0033597
 protein coding gene Chr8:70381672-70409140 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033495
 protein coding gene Chr8:78303843-78331556 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034203
 protein coding gene Chr8:69580315-69608213 (-)
PWK/PhJ MGP_PWKPhJ_G0032411
 protein coding gene Chr8:66491115-66519249 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032247
 protein coding gene Chr8:68554154-68582997 (-)
WSB/EiJ MGP_WSBEiJ_G0032818
 protein coding gene Chr8:69941362-69968851 (-)



Homology
more
  • Human Ortholog
    NCAN, neurocan
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NCAN, neurocan
  • Synonyms
    CSPG3
  • Links
    NCBI Gene ID: 1463
    neXtProt AC: NX_O14594
    UniProt: O14594

  • Chr Location
    19p13.11; chr19:19211958-19252233 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 3 alleles in 1 genetic background
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for targeted null mutations are viable and fertile and exhibit normal behavior and brain anatomy; however, mild defects in long term potentiation were noted.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    949
  • Tissues
    107
  • cDNA Data
    14
  • Literature Summary
    23
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 13004 NCBI Gene Model | MGI Sequence Detail 27760 C57BL/6J ±  kb
transcript NM_007789 RefSeq | MGI Sequence Detail 7184 ZRU/MplStud  
polypeptide P55066 UniProt | EBI | MGI Sequence Detail 1268 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 19
    Genomic 1
    cDNA 16
    Primer pair 2

    Microarray probesets 8
Other
Accession IDs
less
MGD-MRK-18658, MGD-MRK-27057, MGI:101837, MGI:1097681
References
more
  • Summaries
    All 80
    Developmental Gene Expression 23
    Gene Ontology 8
    Phenotypes 17
  • Earliest
    J:17902 Weisz PV, et al., Expression of a TGF beta regulated, brain-specific mRNA in serum-free mouse embryo (SFME) cells. Neurosci Lett. 1993 May 14;154(1-2):153-6
  • Latest
    J:351385 Kaneko N, et al., ADAMTS2 promotes radial migration by activating TGF-beta signaling in the developing neocortex. EMBO Rep. 2024 Jul;25(7):3090-3115
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory