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Meis1 Gene Detail
Summary
  • Symbol
    Meis1
  • Name
    Meis homeobox 1
  • Synonyms
    C530044H18Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:104717
    NCBI Gene: 17268
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:18830428-18968992 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 11.11 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3042 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104717
 protein coding gene Chr11:18829817-18968992 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018061
 protein coding gene Chr11:16298489-16440994 (-)
A/J MGP_AJ_G0018034
 protein coding gene Chr11:15761456-15902317 (-)
AKR/J MGP_AKRJ_G0017998
 protein coding gene Chr11:16307275-16451023 (-)
BALB/cJ MGP_BALBcJ_G0018002
 protein coding gene Chr11:15875668-16015841 (-)
C3H/HeJ MGP_C3HHeJ_G0017816
 protein coding gene Chr11:16239215-16382716 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018454
 protein coding gene Chr11:17048391-17196580 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016112
 protein coding gene Chr11:14824519-14964933 (-)
CAST/EiJ MGP_CASTEiJ_G0017377
 protein coding gene Chr11:16182663-16326980 (-)
CBA/J MGP_CBAJ_G0017790
 protein coding gene Chr11:17780116-17932352 (-)
DBA/2J MGP_DBA2J_G0017900
 protein coding gene Chr11:15744942-15885113 (-)
FVB/NJ MGP_FVBNJ_G0017892
 protein coding gene Chr11:15480918-15622473 (-)
LP/J MGP_LPJ_G0017971
 protein coding gene Chr11:16462982-16609653 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017918
 protein coding gene Chr11:18285749-18431031 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018495
 protein coding gene Chr11:16397499-16539143 (-)
PWK/PhJ MGP_PWKPhJ_G0017157
 protein coding gene Chr11:15689516-15832414 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016954
 protein coding gene Chr11:16123808-16264187 (-)
WSB/EiJ MGP_WSBEiJ_G0017431
 protein coding gene Chr11:16074652-16220801 (-)



Homology
more
  • Human Ortholog
    MEIS1, Meis homeobox 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MEIS1, Meis homeobox 1
  • Links
    NCBI Gene ID: 4211
    neXtProt AC: NX_O00470
    UniProt: O00470

  • Chr Location
    2p14; chr2:66433452-66573869 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Meis1 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    43 phenotypes from 7 alleles in 9 genetic backgrounds
    14 phenotypes from multigenic genotypes
    55 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice die during gestation and exhibit eye, vasculature, and hematopoietic defects. Mice homozygous for a conditional allele activated in HSCs exhibit altered bone marrow cell development, altered HSC physiology and increased reactive oxygen species production. Homozygosity for the p.R272H mutation affects sleeping behavior in aged mice.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    43
  • GO References
    26
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1468
  • Tissues
    379
  • cDNA Data
    33
  • Literature Summary
    141
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17268 NCBI Gene Model | MGI Sequence Detail 138565 C57BL/6J ±  kb
    transcript NM_001193271 RefSeq | MGI Sequence Detail 3441 ZRU/MplStud  
    polypeptide Q60954 UniProt | EBI | MGI Sequence Detail 390 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 71
      Genomic 9
      cDNA 36
      Primer pair 8
      Other 18

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-27080, MGI:2443806
    References
    more
    • Summaries
      All 233
      Developmental Gene Expression 141
      Diseases 1
      Gene Ontology 26
      Phenotypes 55
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:350503 Leu CL, et al., A patient-enriched MEIS1 coding variant causes a restless legs syndrome-like phenotype in mice. Sleep. 2024 May 10;47(5)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory