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Ndst1 Gene Detail
Summary
  • Symbol
    Ndst1
  • Name
    N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
  • Synonyms
    1200015G06Rik, b2b2230Clo, glucosaminyl N-deacetylase/N-sulfotransferase 1, Hsst, Ndst-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:104719
    NCBI Gene: 15531
  • Alliance
    gene page
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:60817566-60881722 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 34.38 cM, cytoband D2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1829 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104719
 protein coding gene Chr18:60817566-60907465 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024466
 protein coding gene Chr18:60509372-60550500 (-)
A/J MGP_AJ_G0024433
 protein coding gene Chr18:57915881-57956260 (-)
AKR/J MGP_AKRJ_G0024403
 protein coding gene Chr18:59516840-59544230 (-)
BALB/cJ MGP_BALBcJ_G0024432
 protein coding gene Chr18:58049131-58076462 (-)
C3H/HeJ MGP_C3HHeJ_G0024200
 protein coding gene Chr18:59748144-59775941 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024879
 protein coding gene Chr18:62166725-62194032 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022310
 protein coding gene Chr18:57470373-57498161 (-)
CAST/EiJ MGP_CASTEiJ_G0023673
 protein coding gene Chr18:59610817-59640258 (-)
CBA/J MGP_CBAJ_G0024170
 protein coding gene Chr18:64182120-64213562 (-)
DBA/2J MGP_DBA2J_G0024300
 protein coding gene Chr18:57598759-57626352 (-)
FVB/NJ MGP_FVBNJ_G0024266
 protein coding gene Chr18:56995182-57027047 (-)
LP/J MGP_LPJ_G0024383
 protein coding gene Chr18:60363892-60402551 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024295
 protein coding gene Chr18:65810822-65851417 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024926
 protein coding gene Chr18:59703470-59748642 (-)
PWK/PhJ MGP_PWKPhJ_G0023416
 protein coding gene Chr18:57821207-57849507 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023222
 protein coding gene Chr18:59943082-59985906 (-)
WSB/EiJ MGP_WSBEiJ_G0023737
 protein coding gene Chr18:59565040-59593468 (-)



Homology
more
  • Human Ortholog
    NDST1, N-deacetylase and N-sulfotransferase 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NDST1, N-deacetylase and N-sulfotransferase 1
  • Synonyms
    HSST, MRT46, NST1
  • Links
    NCBI Gene ID: 3340
    neXtProt AC: NX_P52848
    UniProt: P52848

  • Chr Location
    5q33.1; chr5:150485818-150558211 (+)  GRCh38
Human Diseases
more
  • Diseases
    3 with Ndst1 mouse models; 1 with human NDST1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 1 model
IDs
 View 2 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    4 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    70 phenotypes from 6 alleles in 8 genetic backgrounds
    31 phenotypes from multigenic genotypes
    20 images
    60 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene die late in gestation or neonatally. Lungs fail to inflate and mice born alive experience respiratory distress and failure.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    51
  • GO References
    21
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    874
  • Tissues
    135
  • cDNA Data
    17
  • Literature Summary
    16
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000054008 Ensembl Gene Model | MGI Sequence Detail 64157 C57BL/6J ±  kb
    transcript ENSMUST00000237783 Ensembl | MGI Sequence Detail 6478 Not Applicable  
    polypeptide ENSMUSP00000158312 Ensembl | MGI Sequence Detail 882 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 23
      cDNA 20
      Primer pair 3

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-27082, MGI:1921391, MGI:5491170
    References
    more
    • Summaries
      All 113
      Developmental Gene Expression 16
      Diseases 4
      Gene Ontology 21
      Phenotypes 60
    • Earliest
      J:17539 Eriksson I, et al., cDNA cloning and sequencing of mouse mastocytoma glucosaminyl N-deacetylase/N-sulfotransferase, an enzyme involved in the biosynthesis of heparin. J Biol Chem. 1994 Apr 8;269(14):10438-43
    • Latest
      J:353621 Patel VN, et al., Specific 3-O-sulfated heparan sulfate domains regulate salivary gland basement membrane metabolism and epithelial differentiation. Nat Commun. 2024 Aug 31;15(1):7584
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory