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Cplx1 Gene Detail
Summary
  • Symbol
    Cplx1
  • Name
    complexin 1
  • Synonyms
    921-S
  • Feature Type
    protein coding gene
  • IDs
    MGI:104727
    NCBI Gene: 12889
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:108666420-108697890 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 53.17 cM
Strain
Comparison
more
  • SNPs within 2kb
    875 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104727
 protein coding gene Chr5:108666420-108697893 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029858
 protein coding gene Chr5:110637842-110672027 (-)
A/J MGP_AJ_G0029822
 protein coding gene Chr5:106384117-106415782 (-)
AKR/J MGP_AKRJ_G0029767
 protein coding gene Chr5:109808987-109842305 (-)
BALB/cJ MGP_BALBcJ_G0029834
 protein coding gene Chr5:107523461-107555518 (-)
C3H/HeJ MGP_C3HHeJ_G0029556
 protein coding gene Chr5:110306065-110340850 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030288
 protein coding gene Chr5:115151481-115186325 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027522
 protein coding gene Chr5:101397495-101429606 (-)
CAST/EiJ MGP_CASTEiJ_G0028970
 protein coding gene Chr5:109198752-109230009 (-)
CBA/J MGP_CBAJ_G0029524
 protein coding gene Chr5:119045505-119080564 (-)
DBA/2J MGP_DBA2J_G0029670
 protein coding gene Chr5:106512232-106543620 (-)
FVB/NJ MGP_FVBNJ_G0029627
 protein coding gene Chr5:105239507-105270770 (-)
LP/J MGP_LPJ_G0029758
 protein coding gene Chr5:111219961-111254161 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029659
 protein coding gene Chr5:123937361-123970701 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030322
 protein coding gene Chr5:109368187-109399777 (-)
PWK/PhJ MGP_PWKPhJ_G0028683
 protein coding gene Chr5:105332250-105364274 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028521
 protein coding gene Chr5:106890384-106925494 (-)
WSB/EiJ MGP_WSBEiJ_G0029043
 protein coding gene Chr5:109688294-109719925 (-)



Homology
more
  • Human Ortholog
    CPLX1, complexin 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CPLX1, complexin 1
  • Synonyms
    CPX1, CPX-I, DEE63, EIEE63
  • Links
    NCBI Gene ID: 10815
    neXtProt AC: NX_O14810
    UniProt: O14810

  • Chr Location
    4p16.3; chr4:784957-826129 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human CPLX1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 1 allele in 1 genetic background
    12 phenotypes from multigenic genotypes
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions of this gene suffer from ataxia, are unable to reproduce, and die within 2-4 months of age.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    33
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    961
  • Tissues
    57
  • cDNA Data
    29
  • Literature Summary
    13
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000033615 Ensembl Gene Model | MGI Sequence Detail 31471 C57BL/6J ±  kb
    transcript ENSMUST00000046892 Ensembl | MGI Sequence Detail 2189 Not Applicable  
    polypeptide ENSMUSP00000038502 Ensembl | MGI Sequence Detail 134 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 31
      Genomic 1
      cDNA 30

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-27090
    References
    more
    • Summaries
      All 69
      Developmental Gene Expression 13
      Gene Ontology 9
      Phenotypes 28
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:352584 Grasso EM, et al., Membrane Binding Induces Distinct Structural Signatures in the Mouse Complexin-1C-Terminal Domain. J Mol Biol. 2023 Jan 15;435(1):167710
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory