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Cdkn2b Gene Detail
Summary
  • Symbol
    Cdkn2b
  • Name
    cyclin dependent kinase inhibitor 2B
  • Synonyms
    MTS2, p15, p15INK4b
  • Feature Type
    protein coding gene
  • IDs
    MGI:104737
    NCBI Gene: 12579
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:89224536-89229276 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 42.15 cM, cytoband C3-C6
  • Mapping Data
    13 experiments
Strain
Comparison
more
  • SNPs within 2kb
    240 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104737
 protein coding gene Chr4:89224526-89229276 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028442
 protein coding gene Chr4:89267081-89271849 (-)
A/J MGP_AJ_G0028404
 protein coding gene Chr4:86123380-86128157 (-)
AKR/J MGP_AKRJ_G0028352
 protein coding gene Chr4:88251414-88256184 (-)
BALB/cJ MGP_BALBcJ_G0028423
 protein coding gene Chr4:86359182-86363979 (-)
C3H/HeJ MGP_C3HHeJ_G0028135
 protein coding gene Chr4:89005071-89009816 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028862
 protein coding gene Chr4:92632692-92637435 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026157
 protein coding gene Chr4:82036566-82041202 (-)
CAST/EiJ MGP_CASTEiJ_G0027576
 protein coding gene Chr4:86845521-86850270 (-)
CBA/J MGP_CBAJ_G0028105
 protein coding gene Chr4:95518753-95523498 (-)
DBA/2J MGP_DBA2J_G0028255
 protein coding gene Chr4:85874197-85878967 (-)
FVB/NJ MGP_FVBNJ_G0028222
 protein coding gene Chr4:84812210-84816953 (-)
LP/J MGP_LPJ_G0028355
 protein coding gene Chr4:89540602-89545370 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028251
 protein coding gene Chr4:100480150-100484918 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028900
 protein coding gene Chr4:88405449-88410217 (-)
PWK/PhJ MGP_PWKPhJ_G0027300
 protein coding gene Chr4:84172207-84179660 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027121
 protein coding gene Chr4:85930645-85937210 (-)
WSB/EiJ MGP_WSBEiJ_G0027654
 protein coding gene Chr4:88614940-88619691 (-)



Homology
more
  • Human Ortholog
    CDKN2B, cyclin dependent kinase inhibitor 2B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CDKN2B, cyclin dependent kinase inhibitor 2B
  • Synonyms
    CDK4I, INK4B, MTS2, P15, p15INK4b, TP15
  • Links
    NCBI Gene ID: 1030
    neXtProt AC: NX_P42772
    UniProt: P42772

  • Chr Location
    9p21.3; chr9:22002903-22009313 (-)  GRCh38
Human Diseases
more
  • Diseases
    11 with human CDKN2B associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 2 alleles in 2 genetic backgrounds
    25 phenotypes from multigenic genotypes
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Animals homozygous for a mutation in this gene exhibit increased tumor incidence, lymphoid hyperplasia, and extramedullary hematopoiesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    41
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    844
  • Tissues
    66
  • cDNA Data
    26
  • Literature Summary
    50
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000073802 Ensembl Gene Model | MGI Sequence Detail 4741 C57BL/6J ±  kb
    transcript ENSMUST00000097981 Ensembl | MGI Sequence Detail 1390 Not Applicable  
    polypeptide ENSMUSP00000095595 Ensembl | MGI Sequence Detail 130 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 46
      Genomic 8
      cDNA 26
      Primer pair 10
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-27100, MGI:2140526
    References
    more
    • Summaries
      All 142
      Developmental Gene Expression 50
      Gene Ontology 6
      Phenotypes 27
    • Earliest
      J:20317 Hannon GJ, et al., p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest [see comments]. Nature. 1994 Sep 15;371(6494):257-61
    • Latest
      J:335592 de Lope C, et al., Dysfunction of programmed embryo senescence is linked to genetic developmental defects. Development. 2023 May 1;150(9):dev200903
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    12/10/2024
    MGI 6.24     		The Jackson Laboratory