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Kcnj3 Gene Detail
Summary
  • Symbol
    Kcnj3
  • Name
    potassium inwardly-rectifying channel, subfamily J, member 3
  • Synonyms
    GIRK1, Kcnf3, Kir3.1
  • Feature Type
    protein coding gene
  • IDs
    MGI:104742
    NCBI Gene: 16519
  • Alliance
    gene page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:55325982-55488157 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 31.66 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4795 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104742
 protein coding gene Chr2:55301814-55488157 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025742
 protein coding gene Chr2:54880746-55049294 (+)
A/J MGP_AJ_G0025718
 protein coding gene Chr2:52784745-52953590 (+)
AKR/J MGP_AKRJ_G0025688
 protein coding gene Chr2:54300528-54474987 (+)
BALB/cJ MGP_BALBcJ_G0025713
 protein coding gene Chr2:52875115-53044596 (+)
C3H/HeJ MGP_C3HHeJ_G0025474
 protein coding gene Chr2:54314533-54486192 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026159
 protein coding gene Chr2:56544445-56723498 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023565
 protein coding gene Chr2:50520088-50683017 (+)
CAST/EiJ MGP_CASTEiJ_G0024939
 protein coding gene Chr2:54335370-54503359 (+)
CBA/J MGP_CBAJ_G0025454
 protein coding gene Chr2:58658504-58856654 (+)
DBA/2J MGP_DBA2J_G0025585
 protein coding gene Chr2:52371193-52539693 (+)
FVB/NJ MGP_FVBNJ_G0025547
 protein coding gene Chr2:52006916-52163775 (+)
LP/J MGP_LPJ_G0025673
 protein coding gene Chr2:54763395-54936454 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025578
 protein coding gene Chr2:59902334-60124241 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026217
 protein coding gene Chr2:54206527-54371743 (+)
PWK/PhJ MGP_PWKPhJ_G0024680
 protein coding gene Chr2:52191566-52355035 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024486
 protein coding gene Chr2:54333485-54497802 (+)
WSB/EiJ MGP_WSBEiJ_G0025006
 protein coding gene Chr2:54473533-54647269 (+)



Homology
more
  • Human Ortholog
    KCNJ3, potassium inwardly rectifying channel subfamily J member 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KCNJ3, potassium inwardly rectifying channel subfamily J member 3
  • Synonyms
    GIRK1, KGA, KIR3.1
  • Links
    NCBI Gene ID: 3760
    neXtProt AC: NX_P48549
    UniProt: P48549

  • Chr Location
    2q24.1; chr2:154697855-154858354 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 2 alleles in 3 genetic backgrounds
    35 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted null mutation display slightly increased resting heart rates, and blunted responses to both indirect vagal activation and direct adenosine A1 receptor activation (intended to activate the muscarinic-gated atrial potassium channel).
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    801
  • Tissues
    56
  • cDNA Data
    9
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000026824 Ensembl Gene Model | MGI Sequence Detail 162176 C57BL/6J ±  kb
    transcript ENSMUST00000067101 Ensembl | MGI Sequence Detail 5215 Not Applicable  
    polypeptide ENSMUSP00000063329 Ensembl | MGI Sequence Detail 501 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000002002 G protein-activated inward rectifier potassium channel 1
      (term hierarchy)
    • PDB
      1N9P, 1U4E, 2QKS, 3K6N, 5UM4
    • InterPro Domains
      IPR014756 Immunoglobulin E-set
      IPR041647 Inward rectifier potassium channel, C-terminal
      IPR016449 Potassium channel, inwardly rectifying, Kir
      IPR003274 Potassium channel, inwardly rectifying, Kir3.1
      IPR013518 Potassium channel, inwardly rectifying, Kir, cytoplasmic
      IPR040445 Potassium channel, inwardly rectifying, transmembrane domain
    • GlyGen
      P63250 3 sites, 1 O-linked glycan (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 13
      Genomic 1
      cDNA 9
      Primer pair 3

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-16305, MGD-MRK-28033
    References
    more
    • Summaries
      All 85
      Developmental Gene Expression 10
      Gene Ontology 10
      Phenotypes 35
    • Earliest
      J:18699 Morishige K, et al., Molecular cloning and functional expression of a novel brain-specific inward rectifier potassium channel. FEBS Lett. 1994 Jun 13;346(2-3):251-6
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory