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Itga9 Gene Detail
Summary
  • Symbol
    Itga9
  • Name
    integrin alpha 9
  • Synonyms
    2610002H11Rik, 6720458D17Rik, D9Ertd428e
  • Feature Type
    protein coding gene
  • IDs
    MGI:104756
    NCBI Gene: 104099
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:118435777-118730071 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 70.32 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    10156 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104756
 protein coding gene Chr9:118435758-118730071 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035407
 protein coding gene Chr9:121293037-121615988 (+)
A/J MGP_AJ_G0035387
 protein coding gene Chr9:116812906-117117972 (+)
AKR/J MGP_AKRJ_G0035320
 protein coding gene Chr9:119832221-120147686 (+)
BALB/cJ MGP_BALBcJ_G0035383
 protein coding gene Chr9:116677430-116978985 (+)
C3H/HeJ MGP_C3HHeJ_G0035091
 protein coding gene Chr9:120307388-120614998 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035906
 protein coding gene Chr9:124608046-124931731 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032789
 protein coding gene Chr9:114015957-114308052 (+)
CAST/EiJ MGP_CASTEiJ_G0034395
 protein coding gene Chr9:120262163-120573900 (+)
CBA/J MGP_CBAJ_G0035058
 protein coding gene Chr9:129296021-129636495 (+)
DBA/2J MGP_DBA2J_G0035217
 protein coding gene Chr9:116255777-116552479 (+)
FVB/NJ MGP_FVBNJ_G0035164
 protein coding gene Chr9:115091307-115393103 (+)
LP/J MGP_LPJ_G0035296
 protein coding gene Chr9:121640506-121948604 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035205
 protein coding gene Chr9:130330368-130641572 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035925
 protein coding gene Chr9:120215189-120531992 (+)
PWK/PhJ MGP_PWKPhJ_G0034102
 protein coding gene Chr9:116638486-116956286 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033936
 protein coding gene Chr9:120300688-120627917 (+)
WSB/EiJ MGP_WSBEiJ_G0034516
 protein coding gene Chr9:120111456-120420320 (+)



Homology
more
  • Human Ortholog
    ITGA9, integrin subunit alpha 9
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ITGA9, integrin subunit alpha 9
  • Synonyms
    ALPHA-RLC, ITGA4L, RLC
  • Links
    NCBI Gene ID: 3680
    neXtProt AC: NX_Q13797
    UniProt: Q13797

  • Chr Location
    3p22.2; chr3:37452115-37823507 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Itga9 mouse models; 3 with human ITGA9 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 2 alleles in 3 genetic backgrounds
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in respiratory distress leading to postnatal lethality caused by an accumulation of pleural fluid rich in triglyceride, cholesterol and lymphocytes. Mice develop edema and lymphocytic infiltration in the chest wall.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    995
  • Tissues
    175
  • cDNA Data
    87
  • Literature Summary
    44
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 104099 NCBI Gene Model | MGI Sequence Detail 294295 C57BL/6J ±  kb
    transcript NM_133721 RefSeq | MGI Sequence Detail 7001 ZRU/MplStud  
    polypeptide B8JK39 UniProt | EBI | MGI Sequence Detail 1036 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000009134 integrin alpha-9
      (term hierarchy)
    • InterPro Domains
      IPR013517 FG-GAP repeat
      IPR013519 Integrin alpha beta-propellor
      IPR000413 Integrin alpha chain
      IPR018184 Integrin alpha chain, C-terminal cytoplasmic region, conserved site
      IPR013649 Integrin alpha, first immunoglubulin-like domain
      IPR028994 Integrin alpha, N-terminal
      IPR048285 Integrin alpha, second immunoglobulin-like domain
      IPR048286 Integrin alpha, third immunoglobulin-like domain
      IPR032695 Integrin domain superfamily
    • GlyGen
      B8JK39 7 sites, 3 N-linked glycans (5 sites)
    Molecular
    Reagents
    less
    • All nucleic 88
      cDNA 87
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-28047, MGI:1196244, MGI:1917357, MGI:2143064
    References
    more
    • Summaries
      All 115
      Developmental Gene Expression 44
      Diseases 1
      Gene Ontology 11
      Phenotypes 23
    • Earliest
      J:15817 Palmer EL, et al., Sequence and tissue distribution of the integrin alpha 9 subunit, a novel partner of beta 1 that is widely distributed in epithelia and muscle [published erratum appears in J Cell Biol 1994 Feb;124(3):395]. J Cell Biol. 1993 Dec;123(5):1289-97
    • Latest
      J:352034 Niibori-Nambu A, et al., Integrin-alpha9 overexpression underlies the niche-independent maintenance of leukemia stem cells in acute myeloid leukemia. Gene. 2024 Jul 11;928:148761
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory