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Adra1a Gene Detail
Summary
  • Symbol
    Adra1a
  • Name
    adrenergic receptor, alpha 1a
  • Synonyms
    Adra1c
  • Feature Type
    protein coding gene
  • IDs
    MGI:104773
    NCBI Gene: 11549
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:66872700-67008617 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 34.60 cM, cytoband D1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3904 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104773
 protein coding gene Chr14:66872700-67009549 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021496
 protein coding gene Chr14:61320796-61424677 (+)
A/J MGP_AJ_G0021455
 protein coding gene Chr14:59848259-59949138 (+)
AKR/J MGP_AKRJ_G0021431
 protein coding gene Chr14:61922859-62019944 (+)
BALB/cJ MGP_BALBcJ_G0021461
 protein coding gene Chr14:59824311-59921909 (+)
C3H/HeJ MGP_C3HHeJ_G0021238
 protein coding gene Chr14:61622148-61725476 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021900
 protein coding gene Chr14:64128064-64232726 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019440
 protein coding gene Chr14:57780901-57875640 (+)
CAST/EiJ MGP_CASTEiJ_G0020755
 protein coding gene Chr14:58094220-58192624 (+)
CBA/J MGP_CBAJ_G0021205
 protein coding gene Chr14:66084315-66201654 (+)
DBA/2J MGP_DBA2J_G0021328
 protein coding gene Chr14:59500218-59598298 (+)
FVB/NJ MGP_FVBNJ_G0021307
 protein coding gene Chr14:58911699-59009543 (+)
LP/J MGP_LPJ_G0021403
 protein coding gene Chr14:62362554-62465364 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021336
 protein coding gene Chr14:65111387-65211592 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021923
 protein coding gene Chr14:61133770-61234105 (+)
PWK/PhJ MGP_PWKPhJ_G0020499
 protein coding gene Chr14:56246954-56343416 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020332
 protein coding gene Chr14:57096953-57205486 (+)
WSB/EiJ MGP_WSBEiJ_G0020808
 protein coding gene Chr14:61436182-61545267 (+)



Homology
more
  • Human Ortholog
    ADRA1A, adrenoceptor alpha 1A
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ADRA1A, adrenoceptor alpha 1A
  • Synonyms
    ADRA1C, ADRA1L1, ALPHA1AAR
  • Links
    NCBI Gene ID: 148
    neXtProt AC: NX_P35348
    UniProt: P35348

  • Chr Location
    8p21.2; chr8:26748150-26867379 (-)  GRCh38
Human Diseases
more
  • Diseases
    3 with human ADRA1A associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    17 phenotypes from multigenic genotypes
    35 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutations in this gene result in hypotension.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    71
  • GO References
    19
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    754
  • Tissues
    25
  • cDNA Data
    13
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000045875 Ensembl Gene Model | MGI Sequence Detail 135918 C57BL/6J ±  kb
    transcript ENSMUST00000161339 Ensembl | MGI Sequence Detail 2788 Not Applicable  
    polypeptide ENSMUSP00000125354 Ensembl | MGI Sequence Detail 466 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 17
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-28065
    References
    more
    • Summaries
      All 101
      Developmental Gene Expression 6
      Gene Ontology 19
      Phenotypes 35
    • Earliest
      J:14806 Serfas MS, et al., HNF-1 alpha and HNF-1 beta expression in mouse intestinal crypts. Am J Physiol. 1993 Sep;265(3 Pt 1):G506-13
    • Latest
      J:345649 Sandroni PB, et al., The alpha-1A adrenergic receptor regulates mitochondrial oxidative metabolism in the mouse heart. J Mol Cell Cardiol. 2024 Feb;187:101-117
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory