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Tnf Gene Detail
Summary
  • Symbol
    Tnf
  • Name
    tumor necrosis factor
  • Synonyms
    DIF, Tnfa, TNF alpha, TNF-alpha, TNFalpha, Tnfsf1a, tumor necrosis factor-alpha
  • Feature Type
    protein coding gene
  • IDs
    MGI:104798
    NCBI Gene: 21926
  • Alliance
    gene page
  • Transcription Start Sites
    21 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:35418357-35420983 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 18.59 cM
  • Mapping Data
    50 experiments
Strain
Comparison
more
  • Strain Annotations
    18
  • PCR
    10
  • RFLP
    12
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104798
 protein coding gene Chr17:35418343-35420983 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023628
 protein coding gene Chr17:35348086-35351882 (-)
A/J MGP_AJ_G0023587
 protein coding gene Chr17:34169720-34172348 (-)
AKR/J MGP_AKRJ_G0023556
 protein coding gene Chr17:34650677-34653306 (-)
BALB/cJ MGP_BALBcJ_G0023594
 protein coding gene Chr17:34313994-34316622 (-)
C3H/HeJ MGP_C3HHeJ_G0023355
 protein coding gene Chr17:35056009-35058638 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024033
 protein coding gene Chr17:36693785-36696411 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021514
 protein coding gene Chr17:31941242-31943883 (-)
CAST/EiJ MGP_CASTEiJ_G0022851
 protein coding gene Chr17:35058033-35060661 (-)
CBA/J MGP_CBAJ_G0023333
 protein coding gene Chr17:38206494-38209123 (-)
DBA/2J MGP_DBA2J_G0023461
 protein coding gene Chr17:33497062-33499690 (-)
FVB/NJ MGP_FVBNJ_G0023428
 protein coding gene Chr17:33338751-33341383 (-)
LP/J MGP_LPJ_G0023538
 protein coding gene Chr17:35677968-35680594 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023450
 protein coding gene Chr17:37134689-37137315 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024078
 protein coding gene Chr17:34879278-34881913 (-)
PWK/PhJ MGP_PWKPhJ_G0022599
 protein coding gene Chr17:32334333-32336960 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022419
 protein coding gene Chr17:32886439-32889072 (-)
WSB/EiJ MGP_WSBEiJ_G0022915
 protein coding gene Chr17:35002467-35005095 (-)



Homology
more
  • Human Ortholog
    TNF, tumor necrosis factor
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TNF, tumor necrosis factor
  • Synonyms
    DIF, IMD127, TNFA, TNF-alpha, TNFSF2, TNLG1F
  • Links
    NCBI Gene ID: 7124
    neXtProt AC: NX_P01375
    UniProt: P01375

  • Chr Location
    6p21.33; chr6:31575565-31578336 (+)  GRCh38
Human Diseases
more
  • Diseases
    9 with Tnf mouse models; 82 with human TNF associations

Human Disease Mouse Models
      
IDs
 View 2 models
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Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    10 with disease annotations
  • References
    12 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    294 phenotypes from 29 alleles in 48 genetic backgrounds
    101 phenotypes from multigenic genotypes
    1 images
    934 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutations at this locus primarily affect the immune system, causing increased susceptibility to infection, failure to form splenic B-cell follicles, increased inflammation and impaired contact hypersensitivity. Homozygotes also may show metabolic defects. Combined deletions of certain regulatory regions in the 3' UTR are embryonic lethal (homozygous) or cause arthritis and intestinal and cardiac valve inflammation and reduced lifespan (heterozygous).
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    351
  • GO References
    103
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1018
  • Tissues
    133
  • cDNA Data
    25
  • Literature Summary
    126
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024401 Ensembl Gene Model | MGI Sequence Detail 2627 C57BL/6J ±  kb
    transcript ENSMUST00000025263 Ensembl | MGI Sequence Detail 1639 Not Applicable  
    polypeptide ENSMUSP00000025263 Ensembl | MGI Sequence Detail 235 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 111
      Genomic 53
      cDNA 26
      Primer pair 25
      Other 7

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-15151, MGD-MRK-28090
    References
    more
    • Summaries
      All 2152
      Developmental Gene Expression 126
      Diseases 12
      Gene Ontology 103
      Phenotypes 934
    • Earliest
      J:7045 Rinchik EM, et al., Genetic analysis of the T-H-2 region in non-t chromosomes. I. Two new congenic strains isolate Qglo-1 from H-2. Immunogenetics. 1983;17(5):445-55
    • Latest
      J:355439 Van Roy Z, et al., Tumor necrosis factor regulates leukocyte recruitment but not bacterial persistence during Staphylococcus aureus craniotomy infection. J Neuroinflammation. 2024 Jul 23;21(1):179
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory