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Coil Gene Detail
Summary
  • Symbol
    Coil
  • Name
    coilin
  • Synonyms
    Cln80, p80-coilin
  • Feature Type
    protein coding gene
  • IDs
    MGI:104842
    NCBI Gene: 12812
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:88864761-88882439 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 54.34 cM, cytoband D
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    293 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104842
 protein coding gene Chr11:88861078-88882439 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018928
 protein coding gene Chr11:90729252-90755156 (+)
A/J MGP_AJ_G0018896
 protein coding gene Chr11:87195321-87216464 (+)
AKR/J MGP_AKRJ_G0018866
 protein coding gene Chr11:89867505-89889369 (+)
BALB/cJ MGP_BALBcJ_G0018869
 protein coding gene Chr11:87604388-87632081 (+)
C3H/HeJ MGP_C3HHeJ_G0018683
 protein coding gene Chr11:89874180-89901481 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019321
 protein coding gene Chr11:93494446-93543360 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016952
 protein coding gene Chr11:84219139-84239812 (+)
CAST/EiJ MGP_CASTEiJ_G0018238
 protein coding gene Chr11:90586660-90614315 (+)
CBA/J MGP_CBAJ_G0018654
 protein coding gene Chr11:97485208-97516333 (+)
DBA/2J MGP_DBA2J_G0018762
 protein coding gene Chr11:86742852-86764803 (+)
FVB/NJ MGP_FVBNJ_G0018751
 protein coding gene Chr11:86251344-86270161 (+)
LP/J MGP_LPJ_G0018832
 protein coding gene Chr11:91241216-91279409 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018778
 protein coding gene Chr11:97405618-97429915 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019361
 protein coding gene Chr11:90067316-90092931 (+)
PWK/PhJ MGP_PWKPhJ_G0018008
 protein coding gene Chr11:87602385-87624626 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017776
 protein coding gene Chr11:88006685-89675213 (+)
WSB/EiJ MGP_WSBEiJ_G0018287
 protein coding gene Chr11:89959178-89983608 (+)



Homology
more
  • Human Ortholog
    COIL, coilin
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    COIL, coilin
  • Synonyms
    CLN80, p80-coilin
  • Links
    NCBI Gene ID: 8161
    neXtProt AC: NX_P38432
    UniProt: P38432

  • Chr Location
    17q22; chr17:56938199-56961050 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 2 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Animals homozygous for a mutation in this gene show reduced viability on inbred backgrounds.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    737
  • Tissues
    15
  • cDNA Data
    57
  • Literature Summary
    8
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 12812 NCBI Gene Model | MGI Sequence Detail 17679 C57BL/6J ±  kb
transcript NM_016706 RefSeq | MGI Sequence Detail 2609 ZRU/MplStud  
polypeptide Q5SU73 UniProt | EBI | MGI Sequence Detail 570 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 61
    Genomic 2
    cDNA 57
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-28137, MGI:2144656
References
more
  • Summaries
    All 49
    Developmental Gene Expression 8
    Diseases 1
    Gene Ontology 7
    Phenotypes 16
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:281210 Krejci J, et al., Neural Differentiation in HDAC1-Depleted Cells Is Accompanied by Coilin Downregulation and the Accumulation of Cajal Bodies in Nucleoli. Stem Cells Int. 2017;2017:1021240
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory