About   Help   FAQ
Adora3 Gene Detail
Summary
  • Symbol
    Adora3
  • Name
    adenosine A3 receptor
  • Synonyms
    1700001D09Rik, 4930578J19Rik, A3AR, A3R, AA3R, ARA3, Gpcr 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:104847
    NCBI Gene: 11542
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:105811737-105816244 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 46.45 cM, cytoband F3
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    182 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104847
 protein coding gene Chr3:105778174-105816244 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027721
 protein coding gene Chr3:107254329-107291778 (+)
A/J MGP_AJ_G0027681
 protein coding gene Chr3:103819960-103858204 (+)
AKR/J MGP_AKRJ_G0027646
 protein coding gene Chr3:106401592-106440735 (+)
BALB/cJ MGP_BALBcJ_G0027693
 protein coding gene Chr3:103607350-103645125 (+)
C3H/HeJ MGP_C3HHeJ_G0027423
 protein coding gene Chr3:106738045-106776059 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028137
 protein coding gene Chr3:111258139-111298129 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025477
 protein coding gene Chr3:99903033-99937383 (+)
CAST/EiJ MGP_CASTEiJ_G0026879
 protein coding gene Chr3:105894621-105933494 (+)
CBA/J MGP_CBAJ_G0027398
 protein coding gene Chr3:115007269-115044571 (+)
DBA/2J MGP_DBA2J_G0027540
 protein coding gene Chr3:103067632-103105276 (+)
FVB/NJ MGP_FVBNJ_G0027508
 protein coding gene Chr3:100993606-101030991 (+)
LP/J MGP_LPJ_G0027647
 protein coding gene Chr3:108655527-108694951 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027538
 protein coding gene Chr3:121132638-121172899 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028192
 protein coding gene Chr3:105959611-106000076 (+)
PWK/PhJ MGP_PWKPhJ_G0026605
 protein coding gene Chr3:102847630-102885811 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026426
 protein coding gene Chr3:103980216-104014524 (+)
WSB/EiJ MGP_WSBEiJ_G0026959
 protein coding gene Chr3:106509230-106548407 (+)



Homology
more
  • Human Ortholog
    ADORA3, adenosine A3 receptor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ADORA3, adenosine A3 receptor
  • Synonyms
    A3AR
  • Links
    NCBI Gene ID: 140
    neXtProt AC: NX_P0DMS8
    UniProt: P0DMS8

  • Chr Location
    1p13.2; chr1:111499429-111503633 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 1 allele in 3 genetic backgrounds
    2 phenotypes from multigenic genotypes
    57 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for targeted mutations that inactivate the gene are phenotypically indistinguishable from wild-type mice.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    43
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    723
  • Tissues
    17
  • cDNA Data
    10
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11542 NCBI Gene Model | MGI Sequence Detail 4508 C57BL/6J ±  kb
    transcript NM_009631 RefSeq | MGI Sequence Detail 2372 ZRU/MplStud  
    polypeptide Q61618 UniProt | EBI | MGI Sequence Detail 319 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 10
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-16343, MGD-MRK-28143, MGI:1916546, MGI:1923096, MGI:99563
    References
    more
    • Summaries
      All 101
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 7
      Phenotypes 57
    • Earliest
      J:15563 Wilkie TM, et al., Identification, chromosomal location, and genome organization of mammalian G-protein-coupled receptors. Genomics. 1993 Nov;18(2):175-84
    • Latest
      J:302829 Lu J, et al., Mouse models for human hyperuricaemia: a critical review. Nat Rev Rheumatol. 2019 Jul;15(7):413-426
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory