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Gpx1 Gene Detail
Summary
  • Symbol
    Gpx1
  • Name
    glutathione peroxidase 1
  • Synonyms
    cellular GPx, CGPx, Gpx, GPx-1, GSHPx-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:104887
    NCBI Gene: 14775
  • Alliance
    gene page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:108216279-108217541 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 59.24 cM, cytoband F1
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    88 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104887
 protein coding gene Chr9:108216102-108217542 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035293
 protein coding gene Chr9:110289205-110290645 (+)
A/J MGP_AJ_G0035272
 protein coding gene Chr9:106248485-106249925 (+)
AKR/J MGP_AKRJ_G0035204
 protein coding gene Chr9:108897882-108899322 (+)
BALB/cJ MGP_BALBcJ_G0035266
 protein coding gene Chr9:105945235-105946675 (+)
C3H/HeJ MGP_C3HHeJ_G0034976
 protein coding gene Chr9:109298037-109299477 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035786
 protein coding gene Chr9:113285315-113286755 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032684
 protein coding gene Chr9:103679910-103681346 (+)
CAST/EiJ MGP_CASTEiJ_G0034287
 protein coding gene Chr9:109269855-109271297 (+)
CBA/J MGP_CBAJ_G0034944
 protein coding gene Chr9:117281711-117283151 (+)
DBA/2J MGP_DBA2J_G0035105
 protein coding gene Chr9:105704603-105706043 (+)
FVB/NJ MGP_FVBNJ_G0035053
 protein coding gene Chr9:104470314-104471754 (+)
LP/J MGP_LPJ_G0035181
 protein coding gene Chr9:110486952-110488392 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035092
 protein coding gene Chr9:118867330-118868770 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035807
 protein coding gene Chr9:109193672-109195112 (+)
PWK/PhJ MGP_PWKPhJ_G0033994
 protein coding gene Chr9:106034953-106036393 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033827
 protein coding gene Chr9:109206895-109208339 (+)
WSB/EiJ MGP_WSBEiJ_G0034408
 protein coding gene Chr9:109068376-109069817 (+)



Homology
more
  • Human Ortholog
    GPX1, glutathione peroxidase 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GPX1, glutathione peroxidase 1
  • Synonyms
    GPXD, GSHPX1
  • Links
    NCBI Gene ID: 2876
    neXtProt AC: NX_P07203
    UniProt: P07203

  • Chr Location
    3p21.31; chr3:49357174-49358605 (-)  GRCh38
Human Diseases
more
  • Diseases
    30 with human GPX1 associations

Human Disease Mouse Models
      
IDs
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Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    41 phenotypes from 6 alleles in 9 genetic backgrounds
    21 phenotypes from multigenic genotypes
    140 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations show increased sensitivity to the oxidative stress agents paraquat and hydrogen peroxide and to ischemia/reperfusion and cold-induced brain injury. Mutants also show paradoxical bradykinin-induced vasoconstriction.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    113
  • GO References
    42
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1215
  • Tissues
    232
  • cDNA Data
    1125
  • Literature Summary
    36
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14775 NCBI Gene Model | MGI Sequence Detail 1263 C57BL/6J ±  kb
    transcript NM_008160 RefSeq | MGI Sequence Detail 1066 C57BL/6  
    polypeptide P11352 UniProt | EBI | MGI Sequence Detail 201 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 1147
      Genomic 6
      cDNA 1126
      Primer pair 13
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-10238, MGD-MRK-29040, MGI:2142986, MGI:2143185
    References
    more
    • Summaries
      All 251
      Developmental Gene Expression 36
      Diseases 1
      Gene Ontology 42
      Phenotypes 140
    • Earliest
      J:8354 Chambers I, et al., The structure of the mouse glutathione peroxidase gene: the selenocysteine in the active site is encoded by the 'termination' codon, TGA. EMBO J. 1986 Jun;5(6):1221-7
    • Latest
      J:353356 da Cunha Menezes E, et al., Effects of gestational hypothyroidism on mouse brain development: Gabaergic systems and oxidative stress. Dev Biol. 2024 Nov;515:112-120
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory