About   Help   FAQ
Cdh5 Gene Detail
Summary
  • Symbol
    Cdh5
  • Name
    cadherin 5
  • Synonyms
    7B4/cadherin-5, CD144, VEC, VEcad, VE-Cad, VE-cadherin, VECD
  • Feature Type
    protein coding gene
  • IDs
    MGI:105057
    NCBI Gene: 12562
  • Alliance
    gene page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:104828257-104871143 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 53.04 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1339 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_105057
 protein coding gene Chr8:104828247-104871143 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034000
 protein coding gene Chr8:106205660-106251048 (+)
A/J MGP_AJ_G0033981
 protein coding gene Chr8:101993551-102034851 (+)
AKR/J MGP_AKRJ_G0033908
 protein coding gene Chr8:104942444-104990012 (+)
BALB/cJ MGP_BALBcJ_G0033974
 protein coding gene Chr8:102201794-102250081 (+)
C3H/HeJ MGP_C3HHeJ_G0033686
 protein coding gene Chr8:105638359-105682660 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034495
 protein coding gene Chr8:110100221-110146622 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031438
 protein coding gene Chr8:95302594-95343861 (+)
CAST/EiJ MGP_CASTEiJ_G0033016
 protein coding gene Chr8:105214189-105259662 (+)
CBA/J MGP_CBAJ_G0033660
 protein coding gene Chr8:113731066-113781025 (+)
DBA/2J MGP_DBA2J_G0033814
 protein coding gene Chr8:101356252-101399094 (+)
FVB/NJ MGP_FVBNJ_G0033761
 protein coding gene Chr8:100293070-100335162 (+)
LP/J MGP_LPJ_G0033905
 protein coding gene Chr8:106381636-106426982 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033803
 protein coding gene Chr8:116927373-116971303 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034513
 protein coding gene Chr8:104908680-104954948 (+)
PWK/PhJ MGP_PWKPhJ_G0032717
 protein coding gene Chr8:100765752-100808029 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032555
 protein coding gene Chr8:103747465-103780585 (+)
WSB/EiJ MGP_WSBEiJ_G0033129
 protein coding gene Chr8:105582933-105627002 (+)



Homology
more
  • Human Ortholog
    CDH5, cadherin 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CDH5, cadherin 5
  • Synonyms
    7B4, CD144
  • Links
    NCBI Gene ID: 1003
    neXtProt AC: NX_P33151
    UniProt: P33151

  • Chr Location
    16q21; chr16:66366690-66404784 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Cdh5 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    71 phenotypes from 12 alleles in 10 genetic backgrounds
    3 phenotypes from multigenic genotypes
    49 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous inactivation or cytosolic truncation of this gene causes embryonic growth retardation, abnormal somite and heart development, impaired remodeling and maturation of endothelial cells, increased endothelial apoptosis and severe vascular defects leading to embryonic death at midgestation. Inducible KO in endothelial cells affects retinal angiogenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    97
  • GO References
    19
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1460
  • Tissues
    354
  • cDNA Data
    75
  • Literature Summary
    328
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031871 Ensembl Gene Model | MGI Sequence Detail 42887 C57BL/6J ±  kb
    transcript ENSMUST00000034339 Ensembl | MGI Sequence Detail 3995 Not Applicable  
    polypeptide ENSMUSP00000034339 Ensembl | MGI Sequence Detail 784 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 99
      Genomic 6
      cDNA 75
      Primer pair 16
      Other 2

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-32096, MGI:2142402
    References
    more
    • Summaries
      All 443
      Developmental Gene Expression 328
      Diseases 1
      Gene Ontology 19
      Phenotypes 49
    • Earliest
      J:30623 Breier G, et al., Molecular cloning and expression of murine vascular endothelial-cadherin in early stage development of cardiovascular system. (Errata: vol. 88(3):1129-33). Blood. 1996 Jan 15;87(2):630-41
    • Latest
      J:357839 Nasim S, et al., Multiple cell types including melanocytes contribute to elastogenesis in the developing murine aortic valve. Sci Rep. 2024 Oct 26;14(1):25481
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory