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Clcn2 Gene Detail
Summary
  • Symbol
    Clcn2
  • Name
    chloride channel, voltage-sensitive 2
  • Synonyms
    Clc2, ClC-2, nmf240
  • Feature Type
    protein coding gene
  • IDs
    MGI:105061
    NCBI Gene: 12724
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:20521714-20536496 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 12.50 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    298 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_105061
 protein coding gene Chr16:20521185-20536496 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022653
 protein coding gene Chr16:18052902-18067687 (-)
A/J MGP_AJ_G0022615
 protein coding gene Chr16:17179964-17194751 (-)
AKR/J MGP_AKRJ_G0022590
 protein coding gene Chr16:17827237-17842056 (-)
BALB/cJ MGP_BALBcJ_G0022619
 protein coding gene Chr16:17336283-17351067 (-)
C3H/HeJ MGP_C3HHeJ_G0022384
 protein coding gene Chr16:18000461-18015660 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023070
 protein coding gene Chr16:18408343-18423122 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020588
 protein coding gene Chr16:17863587-17878552 (-)
CAST/EiJ MGP_CASTEiJ_G0021914
 protein coding gene Chr16:17976547-17991377 (-)
CBA/J MGP_CBAJ_G0022356
 protein coding gene Chr16:19156604-19174531 (-)
DBA/2J MGP_DBA2J_G0022488
 protein coding gene Chr16:17107305-17122084 (-)
FVB/NJ MGP_FVBNJ_G0022463
 protein coding gene Chr16:17147330-17163410 (-)
LP/J MGP_LPJ_G0022555
 protein coding gene Chr16:17776622-17791605 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022483
 protein coding gene Chr16:18825036-18841281 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023081
 protein coding gene Chr16:17800434-17815217 (-)
PWK/PhJ MGP_PWKPhJ_G0021655
 protein coding gene Chr16:17376795-17391880 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021485
 protein coding gene Chr16:17600964-17615752 (-)
WSB/EiJ MGP_WSBEiJ_G0021958
 protein coding gene Chr16:17795359-17810103 (-)



Homology
more
  • Human Ortholog
    CLCN2, chloride voltage-gated channel 2
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CLCN2, chloride voltage-gated channel 2
  • Synonyms
    CIC-2, clC-2, CLC2, ECA2, ECA3, EGI11, EGI3, EGMA, EJM6, EJM8, FHA2, FHII, HALD2, LKPAT
  • Links
    NCBI Gene ID: 1181
    neXtProt AC: NX_P51788
    UniProt: P51788

  • Chr Location
    3q27.1; chr3:184346185-184361650 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with Clcn2 mouse models; 2 with human CLCN2 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    60 phenotypes from 6 alleles in 5 genetic backgrounds
    2 phenotypes from multigenic genotypes
    2 images
    37 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit abnormal brain morphology, male infertility, and abnormal eye morphology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    45
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1091
  • Tissues
    78
  • cDNA Data
    43
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022843 Ensembl Gene Model | MGI Sequence Detail 14783 C57BL/6J ±  kb
    transcript ENSMUST00000007207 Ensembl | MGI Sequence Detail 3128 Not Applicable  
    polypeptide ENSMUSP00000007207 Ensembl | MGI Sequence Detail 908 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 47
      cDNA 45
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-32100, MGI:3034882, MGI:3056296
    References
    more
    • Summaries
      All 76
      Developmental Gene Expression 9
      Diseases 2
      Gene Ontology 15
      Phenotypes 37
    • Earliest
      J:29529 Lengeling A, et al., Chloride channel 2 gene (Clc2) maps to chromosome 16 of the mouse, extending a region of conserved synteny with human chromosome 3q. Genet Res. 1995 Oct;66(2):175-8
    • Latest
      J:331730 Goppner C, et al., Cellular basis of ClC-2 Cl(-) channel-related brain and testis pathologies. J Biol Chem. 2021 Jan-Jun;296:100074
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory