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Slc9a2 Gene Detail
Summary
  • Symbol
    Slc9a2
  • Name
    solute carrier family 9 (sodium/hydrogen exchanger), member 2
  • Synonyms
    2210416H12Rik, 4932415O19Rik, NHE2
  • Feature Type
    protein coding gene
  • IDs
    MGI:105075
    NCBI Gene: 226999
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:40720872-40808045 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 19.66 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2715 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_105075
 protein coding gene Chr1:40719734-40808433 (+)
129S1/SvImJ MGP_129S1SvImJ_G0015971
 protein coding gene Chr1:39489141-39583814 (+)
A/J MGP_AJ_G0015955
 protein coding gene Chr1:38370005-38457715 (+)
AKR/J MGP_AKRJ_G0015910
 protein coding gene Chr1:38838913-38926910 (+)
BALB/cJ MGP_BALBcJ_G0015909
 protein coding gene Chr1:38027232-38113166 (+)
C3H/HeJ MGP_C3HHeJ_G0015742
 protein coding gene Chr1:39159345-39251816 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016362
 protein coding gene Chr1:41138728-41243453 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014084
 protein coding gene Chr1:35285084-35370226 (+)
CAST/EiJ MGP_CASTEiJ_G0015323
 protein coding gene Chr1:39050115-39141225 (+)
CBA/J MGP_CBAJ_G0015714
 protein coding gene Chr1:42335638-42442378 (+)
DBA/2J MGP_DBA2J_G0015815
 protein coding gene Chr1:37652135-37740813 (+)
FVB/NJ MGP_FVBNJ_G0015817
 protein coding gene Chr1:37192270-37278792 (+)
LP/J MGP_LPJ_G0015885
 protein coding gene Chr1:39829372-39931950 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0015837
 protein coding gene Chr1:44324572-44421027 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016409
 protein coding gene Chr1:39010794-39099325 (+)
PWK/PhJ MGP_PWKPhJ_G0015106
 protein coding gene Chr1:37467641-37556396 (+)
SPRET/EiJ MGP_SPRETEiJ_G0014888
 protein coding gene Chr1:38981587-39069704 (+)
WSB/EiJ MGP_WSBEiJ_G0015385
 protein coding gene Chr1:38985056-39074729 (+)



Homology
more
  • Human Ortholog
    SLC9A2, solute carrier family 9 member A2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC9A2, solute carrier family 9 member A2
  • Synonyms
    NHE2
  • Links
    NCBI Gene ID: 6549
    neXtProt AC: NX_Q9UBY0
    UniProt: Q9UBY0

  • Chr Location
    2q12.1; chr2:102619553-102711355 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    3 images
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gastric acid secretion is impaired in homozygous mutant mice. The gastric mucosa becomes inflamed and exhibits an altered cellular composition. Mutant mice do not breed well.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    793
  • Tissues
    44
  • cDNA Data
    21
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 226999 NCBI Gene Model | MGI Sequence Detail 87174 C57BL/6J ±  kb
    transcript NM_001033289 RefSeq | MGI Sequence Detail 3493 Not Specified  
    polypeptide Q3ZAS0 UniProt | EBI | MGI Sequence Detail 814 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 25
      Genomic 1
      cDNA 21
      Primer pair 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-32115, MGI:1917419, MGI:2138533, MGI:3036276
    References
    more
    • Summaries
      All 71
      Developmental Gene Expression 6
      Gene Ontology 8
      Phenotypes 30
    • Earliest
      J:17335 Szpirer C, et al., Chromosomal assignment of four genes encoding Na/H exchanger isoforms in human and rat. Mamm Genome. 1994 Mar;5(3):153-9
    • Latest
      J:333125 Nikolovska K, et al., Sodium/hydrogen-exchanger-2 modulates colonocyte lineage differentiation. Acta Physiol (Oxf). 2022 Mar;234(3):e13774
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory