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Ntn1 Gene Detail
Summary
  • Symbol
    Ntn1
  • Name
    netrin 1
  • Synonyms
    Netrin-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:105088
    NCBI Gene: 18208
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:68100190-68277652 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 41.45 cM, cytoband B3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4510 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_105088
 protein coding gene Chr11:68100190-68291649 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018499
 protein coding gene Chr11:68546857-68746863 (-)
A/J MGP_AJ_G0018468
 protein coding gene Chr11:65983602-66176424 (-)
AKR/J MGP_AKRJ_G0018437
 protein coding gene Chr11:67950017-68144413 (-)
BALB/cJ MGP_BALBcJ_G0018439
 protein coding gene Chr11:66271453-66465068 (-)
C3H/HeJ MGP_C3HHeJ_G0018252
 protein coding gene Chr11:67974116-68173435 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018891
 protein coding gene Chr11:70642101-70843812 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016535
 protein coding gene Chr11:62926279-63117853 (-)
CAST/EiJ MGP_CASTEiJ_G0017808
 protein coding gene Chr11:68191246-68399987 (-)
CBA/J MGP_CBAJ_G0018226
 protein coding gene Chr11:73773671-73980122 (-)
DBA/2J MGP_DBA2J_G0018335
 protein coding gene Chr11:65585062-65777749 (-)
FVB/NJ MGP_FVBNJ_G0018325
 protein coding gene Chr11:65203455-65397997 (-)
LP/J MGP_LPJ_G0018406
 protein coding gene Chr11:69122321-69319385 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018348
 protein coding gene Chr11:74488999-74689525 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018932
 protein coding gene Chr11:68198738-68393902 (-)
PWK/PhJ MGP_PWKPhJ_G0017583
 protein coding gene Chr11:66202433-66398584 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017371
 protein coding gene Chr11:68043366-68236277 (-)
WSB/EiJ MGP_WSBEiJ_G0017861
 protein coding gene Chr11:67814529-68017815 (-)



Homology
more
  • Human Ortholog
    NTN1, netrin 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NTN1, netrin 1
  • Synonyms
    MRMV4, NET1, NTN1L
  • Links
    NCBI Gene ID: 9423
    neXtProt AC: NX_O95631
    UniProt: O95631

  • Chr Location
    17p13.1; chr17:9003087-9244000 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human NTN1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    28 phenotypes from 4 alleles in 7 genetic backgrounds
    6 phenotypes from multigenic genotypes
    117 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted mutations exhibit impaired axonal migration, abnormal semicircular canals, lack of corpus callosum, aberrant commissures, optic nerve hypoplasia, motor and balance defects, failure to suckle, and neonatal death. Embryos homozygous for a null allele show bilateral coloboma and cleft secondary palate.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    56
  • GO References
    28
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1534
  • Tissues
    300
  • cDNA Data
    107
  • Literature Summary
    217
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18208 NCBI Gene Model | MGI Sequence Detail 177463 C57BL/6J ±  kb
    transcript NM_008744 RefSeq | MGI Sequence Detail 5757 C57BL/6  
    polypeptide O09118 UniProt | EBI | MGI Sequence Detail 604 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 142
      cDNA 111
      Primer pair 9
      Other 22

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-32128, MGI:2144226, MGI:2652852
    References
    more
    • Summaries
      All 363
      Developmental Gene Expression 217
      Gene Ontology 28
      Phenotypes 117
    • Earliest
      J:5300 Borit A, et al., New mutant mouse with communicating hydrocephalus and secondary aqueductal stenosis. Acta Neuropathol (Berl). 1972;21(4):316-31
    • Latest
      J:357469 Sivori M, et al., The pelvic organs receive no parasympathetic innervation. Elife. 2024;15
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory